TR201905909T4 - Kanser tedavisi için anti-4-1bb antikorlarının ve adcc indükleyici antikorların kombinasyonları. - Google Patents
Kanser tedavisi için anti-4-1bb antikorlarının ve adcc indükleyici antikorların kombinasyonları. Download PDFInfo
- Publication number
- TR201905909T4 TR201905909T4 TR2019/05909T TR201905909T TR201905909T4 TR 201905909 T4 TR201905909 T4 TR 201905909T4 TR 2019/05909 T TR2019/05909 T TR 2019/05909T TR 201905909 T TR201905909 T TR 201905909T TR 201905909 T4 TR201905909 T4 TR 201905909T4
- Authority
- TR
- Turkey
- Prior art keywords
- antibodies
- combinations
- cancer therapy
- adcc inducing
- adcc
- Prior art date
Links
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 238000011275 oncology therapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Abstract
Buna ihtiyacı olan bir hastada kanserin, terapötik olarak etkili miktarda ADCC indükleyici antikor ile kombinasyon halinde terapötik olarak etkili miktarda bir anti-4-1BB antikoru ile tedavi edilmesine yönelik yöntemler açıklanır.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161477153P | 2011-04-19 | 2011-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201905909T4 true TR201905909T4 (tr) | 2019-05-21 |
Family
ID=45952670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/05909T TR201905909T4 (tr) | 2011-04-19 | 2012-04-09 | Kanser tedavisi için anti-4-1bb antikorlarının ve adcc indükleyici antikorların kombinasyonları. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20140178368A1 (tr) |
EP (2) | EP2699598B1 (tr) |
JP (3) | JP2012224631A (tr) |
CA (2) | CA2830972C (tr) |
DK (1) | DK2699598T3 (tr) |
ES (1) | ES2724801T3 (tr) |
TR (1) | TR201905909T4 (tr) |
WO (1) | WO2012145183A2 (tr) |
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-
2012
- 2012-04-09 ES ES12713849T patent/ES2724801T3/es active Active
- 2012-04-09 EP EP12713849.3A patent/EP2699598B1/en active Active
- 2012-04-09 EP EP19160808.2A patent/EP3536708A1/en not_active Withdrawn
- 2012-04-09 WO PCT/US2012/032704 patent/WO2012145183A2/en active Application Filing
- 2012-04-09 US US14/113,764 patent/US20140178368A1/en not_active Abandoned
- 2012-04-09 DK DK12713849.3T patent/DK2699598T3/en active
- 2012-04-09 CA CA2830972A patent/CA2830972C/en active Active
- 2012-04-09 CA CA3019531A patent/CA3019531A1/en not_active Abandoned
- 2012-04-09 TR TR2019/05909T patent/TR201905909T4/tr unknown
- 2012-04-18 JP JP2012094665A patent/JP2012224631A/ja active Pending
-
2016
- 2016-02-01 US US15/012,414 patent/US20160152722A1/en not_active Abandoned
- 2016-08-26 JP JP2016165677A patent/JP6313825B2/ja active Active
-
2018
- 2018-03-23 JP JP2018056131A patent/JP2018115192A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2012145183A3 (en) | 2013-03-14 |
JP6313825B2 (ja) | 2018-04-18 |
EP2699598A2 (en) | 2014-02-26 |
JP2018115192A (ja) | 2018-07-26 |
EP3536708A1 (en) | 2019-09-11 |
WO2012145183A2 (en) | 2012-10-26 |
US20140178368A1 (en) | 2014-06-26 |
DK2699598T3 (en) | 2019-04-23 |
CA3019531A1 (en) | 2012-10-26 |
ES2724801T3 (es) | 2019-09-16 |
JP2012224631A (ja) | 2012-11-15 |
JP2017019830A (ja) | 2017-01-26 |
CA2830972A1 (en) | 2012-10-26 |
CA2830972C (en) | 2018-11-20 |
US20160152722A1 (en) | 2016-06-02 |
EP2699598B1 (en) | 2019-03-06 |
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