BR112012016742A2 - metodos para tratamento de cancer pancreatico - Google Patents

metodos para tratamento de cancer pancreatico

Info

Publication number
BR112012016742A2
BR112012016742A2 BR112012016742A BR112012016742A BR112012016742A2 BR 112012016742 A2 BR112012016742 A2 BR 112012016742A2 BR 112012016742 A BR112012016742 A BR 112012016742A BR 112012016742 A BR112012016742 A BR 112012016742A BR 112012016742 A2 BR112012016742 A2 BR 112012016742A2
Authority
BR
Brazil
Prior art keywords
pancreatic cancer
cancer treatment
treatment methods
methods
treating pancreatic
Prior art date
Application number
BR112012016742A
Other languages
English (en)
Inventor
Joubert Dominique
Hollande Frederic
Houhou Leila
Original Assignee
Biorealites S A S
Centre Nat Rech Scient
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorealites S A S, Centre Nat Rech Scient, Inst Nat Sante Rech Med filed Critical Biorealites S A S
Publication of BR112012016742A2 publication Critical patent/BR112012016742A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/595—Gastrins; Cholecystokinins [CCK]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

métodos para tratamento de câncer pancreático. a presente invenção refere-se a métodos de tratamento de câncer pancreático em indivíduos usando câncer com anticorpos que se ligam especificamente a progastrina.
BR112012016742A 2010-01-08 2011-01-07 metodos para tratamento de cancer pancreatico BR112012016742A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29361210P 2010-01-08 2010-01-08
PCT/EP2011/000049 WO2011083091A2 (en) 2010-01-08 2011-01-07 Methods for treating pancreatic cancer

Publications (1)

Publication Number Publication Date
BR112012016742A2 true BR112012016742A2 (pt) 2018-05-15

Family

ID=43607948

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112012016820A BR112012016820A2 (pt) 2010-01-08 2011-01-07 Metodos para tratamento de cancer de seio
BR112012016742A BR112012016742A2 (pt) 2010-01-08 2011-01-07 metodos para tratamento de cancer pancreatico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112012016820A BR112012016820A2 (pt) 2010-01-08 2011-01-07 Metodos para tratamento de cancer de seio

Country Status (15)

Country Link
US (2) US8900588B2 (pt)
EP (2) EP2542583B8 (pt)
JP (2) JP5572718B2 (pt)
KR (2) KR101468397B1 (pt)
CN (2) CN102892784B (pt)
AU (2) AU2011204653B2 (pt)
BR (2) BR112012016820A2 (pt)
CA (2) CA2786435C (pt)
EA (2) EA025329B1 (pt)
ES (2) ES2657246T3 (pt)
NZ (2) NZ601588A (pt)
PL (2) PL2542584T3 (pt)
SG (2) SG182334A1 (pt)
WO (2) WO2011083090A2 (pt)
ZA (2) ZA201205004B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076454A1 (en) 2006-12-19 2008-06-26 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
US8136651B2 (en) * 2007-12-14 2012-03-20 The Procter & Gamble Company Method and apparatus for orienting articles
PL2598531T3 (pl) * 2010-07-26 2021-08-30 Progastrine Et Cancers S.À R.L. Sposoby i kompozycje do terapii nowotworu wątroby
EP3350224B1 (en) 2015-09-20 2024-06-19 The United States of America, as Represented By the Secretary, Department of Health and Human Services Monoclonal antibodies specific for fibroblast growth factor receptor 4 (fgfr4) and methods of their use
EA037015B1 (ru) * 2015-12-31 2021-01-27 Прогастрин Э Кансер С.А Р.Л. Применение и способ для профилактики или лечения рака яичников с использованием композиции, содержащей прогастринсвязывающее антитело
US20190011449A1 (en) * 2015-12-31 2019-01-10 Progastrine Et Cancers S.À R.L. Compositions and methods for detecting and treating gastric cancer
KR102197478B1 (ko) * 2015-12-31 2021-01-04 프로가스트린 에 캔서스 에스.에이 알.엘. 식도암을 검출 및 치료하기 위한 조성물 및 방법
CN108700586A (zh) * 2015-12-31 2018-10-23 Syncerus有限责任公司 用于评估癌症发生的风险的组合物和方法
ES2932262T3 (es) * 2017-01-06 2023-01-17 Lemonex Inc Composición para la prevención o el tratamiento de cáncer de ovario metastásico, cáncer de endometrio o cáncer de mama
EA201992316A1 (ru) * 2017-03-30 2020-03-05 Эсс-Прогастрин Са Композиции и способы для диагностики рака предстательной железы
AU2018242157B2 (en) * 2017-03-30 2023-02-09 Progastrine et Cancers S.à.r.l. Compositions and methods for treating lung cancer
US11267881B2 (en) 2017-09-14 2022-03-08 Charles ROSSER Compositions and methods for treatment of diseases involving CXCL1 function
SG11202005296SA (en) * 2017-12-05 2020-07-29 Progastrine Et Cancers S A R L Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer
WO2019110845A1 (en) 2017-12-08 2019-06-13 Ecs-Biotracker Sàrl Radiolabeled progastrin in cancer diagnosis
WO2019145537A1 (en) 2018-01-26 2019-08-01 Ecs-Progastrin Sa Combination of progastrin detection with other cancer biomarkers in cancer diagnosis
SG11202008271QA (en) 2018-02-27 2020-09-29 Ecs Progastrin Sa Progastrin as a biomarker for immunotherapy
KR20200132900A (ko) * 2018-03-13 2020-11-25 페인스 테라퓨틱스 인코포레이티드 항-폴레이트 수용체 1 항체 및 이의 용도
CN108864255B (zh) * 2018-06-21 2022-01-04 天津医科大学肿瘤医院 一种乳腺癌干细胞特异性结合多肽及其在制备治疗乳腺癌药物中的应用
CN113544143A (zh) 2019-01-28 2021-10-22 查尔斯·J·罗瑟 用于治疗涉及cxcl1功能的疾病的组合物和方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5922845A (en) * 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US6548066B1 (en) * 1997-05-12 2003-04-15 Aphton Corporation Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
WO2001062288A1 (en) 2000-02-25 2001-08-30 The Regents Of The University Of California Membrane estrogen receptor-directed therapy in breast cancer
FR2846426B1 (fr) 2002-10-28 2004-12-10 Bio Merieux Procede de dosage du ngf pour le diagnostic in vitro du cancer du sein et utilisation en therapie
ES2400058T3 (es) * 2004-09-22 2013-04-05 Cancer Advances, Inc. Anticuerpos monoclonales para progastrina
CA2652768A1 (en) 2006-05-22 2007-11-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Inhibitors of progastrin-induced repression of icat for treating and/or preventing colorectal cancer, adenomatous polyposis or metastasis displaying progastrin-secreting cells andcells in which the beta-catenin/tcf-4-mediated transcriptional pathway is constitutively active
EP2062597A4 (en) 2006-09-15 2010-03-03 Univ Tokai PREVENTIVE OR CLEANING AGENT FOR ER-NEGATIVE AND HER2-NEGATIVE MAMMARY CARCINOMA AND INVESTIGATION METHOD THEREFOR
US20100092476A1 (en) 2006-11-17 2010-04-15 Hanash Samir M Pancreatic cancer biomarkers
WO2008076454A1 (en) 2006-12-19 2008-06-26 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
WO2009042618A1 (en) 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors
PT2488551T (pt) * 2009-10-16 2018-10-31 Inst Nat Sante Rech Med Anticorpos monoclonais contra a progastrina e suas utilizações

Also Published As

Publication number Publication date
KR20120135401A (ko) 2012-12-13
CN102933603A (zh) 2013-02-13
JP6134141B2 (ja) 2017-05-24
WO2011083091A8 (en) 2012-08-09
CA2786435A1 (en) 2011-07-14
KR101468397B1 (ko) 2014-12-04
AU2011204654A1 (en) 2012-07-26
JP2013516439A (ja) 2013-05-13
EP2542584B8 (en) 2017-12-13
EP2542583B1 (en) 2017-10-25
EA201200999A1 (ru) 2013-02-28
ZA201205003B (en) 2013-09-25
SG182331A1 (en) 2012-08-30
US20110171213A1 (en) 2011-07-14
EA201200998A1 (ru) 2013-02-28
EP2542583A2 (en) 2013-01-09
EP2542584A2 (en) 2013-01-09
EA025329B1 (ru) 2016-12-30
CA2786479C (en) 2016-03-15
EP2542583B8 (en) 2017-12-13
CN102892784B (zh) 2016-06-22
ES2657246T3 (es) 2018-03-02
EP2542584B1 (en) 2017-10-25
ES2657245T3 (es) 2018-03-02
JP5572718B2 (ja) 2014-08-13
JP2013516438A (ja) 2013-05-13
US20110177062A1 (en) 2011-07-21
WO2011083090A3 (en) 2011-10-06
WO2011083091A2 (en) 2011-07-14
CA2786479A1 (en) 2011-07-14
US9487582B2 (en) 2016-11-08
CN102933603B (zh) 2016-01-20
BR112012016820A2 (pt) 2023-11-28
AU2011204653A1 (en) 2012-07-26
WO2011083090A2 (en) 2011-07-14
SG182334A1 (en) 2012-08-30
ZA201205004B (en) 2013-09-25
NZ601588A (en) 2014-07-25
KR20130028050A (ko) 2013-03-18
CN102892784A (zh) 2013-01-23
WO2011083091A3 (en) 2011-09-09
PL2542584T3 (pl) 2018-04-30
AU2011204653B2 (en) 2014-04-10
KR101438362B1 (ko) 2014-09-05
AU2011204654B2 (en) 2014-04-10
NZ601591A (en) 2015-01-30
US8900588B2 (en) 2014-12-02
EA023722B1 (ru) 2016-07-29
CA2786435C (en) 2017-01-17
PL2542583T3 (pl) 2018-04-30

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Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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