PE20211778A1 - Anticuerpos biespecificos anti-pd-l1/anti-4-1bb y usos de los mismos - Google Patents

Anticuerpos biespecificos anti-pd-l1/anti-4-1bb y usos de los mismos

Info

Publication number
PE20211778A1
PE20211778A1 PE2021000774A PE2021000774A PE20211778A1 PE 20211778 A1 PE20211778 A1 PE 20211778A1 PE 2021000774 A PE2021000774 A PE 2021000774A PE 2021000774 A PE2021000774 A PE 2021000774A PE 20211778 A1 PE20211778 A1 PE 20211778A1
Authority
PE
Peru
Prior art keywords
specific antibodies
protein
bispecific
antibody
ligand
Prior art date
Application number
PE2021000774A
Other languages
English (en)
Inventor
Eunyoung Park
Yangsoon Lee
Hyejin Chung
Eunsil Sung
Jiseon Yoo
Minji Park
Yong-Gyu Son
Hyoju Choi
Eunjung Kim
Jaeho Jung
Weon-Kyoo You
Sang Hoon Lee
Lei Fang
Wenqing Jiang
Original Assignee
Abl Bio Inc
I Mab Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abl Bio Inc, I Mab Biopharma Co Ltd filed Critical Abl Bio Inc
Publication of PE20211778A1 publication Critical patent/PE20211778A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporciona un anticuerpo biespecifico anti-PD-L1/anti-4-1BB capaz de bloquear de manera eficaz las interacciones entre PD-L1 y su PD-1 receptor y entre 4-1BB y su ligando. El anticuerpo biespecifico puede tener alta afinidad de union tanto a una proteina PD-L1 como una proteina 4-1BB.
PE2021000774A 2018-11-30 2019-02-15 Anticuerpos biespecificos anti-pd-l1/anti-4-1bb y usos de los mismos PE20211778A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862773239P 2018-11-30 2018-11-30
PCT/CN2019/075180 WO2020107715A1 (en) 2018-11-30 2019-02-15 Anti-pd-l1/anti-4-1bb bispecific antibodies and uses thereof

Publications (1)

Publication Number Publication Date
PE20211778A1 true PE20211778A1 (es) 2021-09-08

Family

ID=70852440

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021000774A PE20211778A1 (es) 2018-11-30 2019-02-15 Anticuerpos biespecificos anti-pd-l1/anti-4-1bb y usos de los mismos

Country Status (18)

Country Link
US (2) US20220056136A1 (es)
EP (2) EP3891187A4 (es)
JP (2) JP7328658B2 (es)
KR (2) KR20210099052A (es)
CN (2) CN113286825A (es)
AU (2) AU2019390274A1 (es)
BR (2) BR112021010402A2 (es)
CA (2) CA3121562A1 (es)
CL (1) CL2021001368A1 (es)
CO (1) CO2021006911A2 (es)
EA (1) EA202191457A1 (es)
IL (1) IL283530A (es)
MX (1) MX2021006379A (es)
PE (1) PE20211778A1 (es)
PH (1) PH12021551171A1 (es)
SG (1) SG11202105152YA (es)
WO (2) WO2020107715A1 (es)
ZA (1) ZA202102870B (es)

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EP4004053A4 (en) * 2019-07-26 2023-10-18 ABL Bio, Inc. BISPECIFIC ANTI-EGFR/ANTI-4-1BB ANTIBODIES AND USE THEREOF
CN114206941A (zh) * 2019-07-26 2022-03-18 Abl生物公司 抗her2/抗4-1bb双特异性抗体及其用途
EP3853257A4 (en) * 2019-08-12 2022-06-29 I-Mab Biopharma US Limited Anti-claudin 18.2 and anti-4-1bb bispecific antibodies and uses thereof
US11466086B2 (en) 2019-10-11 2022-10-11 Nanjing Leads Biolabs Co., Ltd. Antibodies binding 4-1BB and uses thereof
KR20230015957A (ko) * 2020-06-30 2023-01-31 하버 바이오메드 유에스, 아이엔씨. 이중특이적 항체 및 이의 용도
IL310780A (en) * 2020-08-18 2024-04-01 Abl Bio Inc ANTI-B7-H4/ANTI-4-1BB bispecific antibodies and their use
CN114195900B (zh) * 2020-09-17 2024-02-23 普米斯生物技术(珠海)有限公司 一种抗4-1bb/pd-l1双特异性抗体及其用途
CN117083080A (zh) * 2020-12-07 2023-11-17 健玛保 抗体和紫杉烷联合疗法
KR102576861B1 (ko) * 2021-01-11 2023-09-11 주식회사 유틸렉스 항-4-1bb 항체 및 pd-1 단백질 또는 이의 단편을 포함하는 이중특이적 에피토프 결합 단백질 및 이의 용도
CN116745309A (zh) * 2021-01-25 2023-09-12 柳韩洋行 用于纯化抗-4-1bb/抗-her2双特异性抗体的方法
WO2023000675A1 (zh) * 2021-07-23 2023-01-26 安徽安科生物工程（集团）股份有限公司 靶向pd-l1和4-1bb的双特异性抗体
CN114736303A (zh) * 2022-03-17 2022-07-12 英诺湖医药(杭州)有限公司 抗pd-l1和4-1bb的双功能抗体及其医药用途
WO2023200865A2 (en) * 2022-04-13 2023-10-19 The Regents Of The University Of California Cancer therapy
WO2024008032A1 (en) * 2022-07-06 2024-01-11 Beijing Hanmi Pharmaceutical Co., Ltd. Formulations for anti-pd-l1/anti-4-1bb bispecific antibodies

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Also Published As

Publication number Publication date
ZA202102870B (en) 2023-05-31
KR20210087094A (ko) 2021-07-09
US20220056136A1 (en) 2022-02-24
EP3887403A4 (en) 2022-08-31
EP3891187A1 (en) 2021-10-13
CA3121218A1 (en) 2020-06-04
EA202191457A1 (ru) 2021-09-06
EP3887403A1 (en) 2021-10-06
CN113166250A (zh) 2021-07-23
PH12021551171A1 (en) 2021-11-29
JP2022510253A (ja) 2022-01-26
US20220242961A1 (en) 2022-08-04
JP2022513694A (ja) 2022-02-09
AU2019386549A1 (en) 2021-06-24
JP7378474B2 (ja) 2023-11-13
EP3891187A4 (en) 2022-10-05
CO2021006911A2 (es) 2021-08-09
SG11202105152YA (en) 2021-06-29
JP7328658B2 (ja) 2023-08-17
MX2021006379A (es) 2021-10-13
CA3121562A1 (en) 2020-06-04
IL283530A (en) 2021-07-29
CL2021001368A1 (es) 2022-03-04
BR112021010402A2 (pt) 2021-08-24
BR112021010394A2 (pt) 2021-08-24
WO2020111913A1 (en) 2020-06-04
KR20210099052A (ko) 2021-08-11
AU2019390274A1 (en) 2021-07-22
CN113166250B (zh) 2023-10-03
CN113286825A (zh) 2021-08-20
WO2020107715A1 (en) 2020-06-04

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