MX2021016066A - Anticuerpos heterodimericos que se unen a cd38 y cd3. - Google Patents
Anticuerpos heterodimericos que se unen a cd38 y cd3.Info
- Publication number
- MX2021016066A MX2021016066A MX2021016066A MX2021016066A MX2021016066A MX 2021016066 A MX2021016066 A MX 2021016066A MX 2021016066 A MX2021016066 A MX 2021016066A MX 2021016066 A MX2021016066 A MX 2021016066A MX 2021016066 A MX2021016066 A MX 2021016066A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- heterodimeric antibodies
- bind
- antibodies
- heterodimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente divulgación proporciona anticuerpos heterodiméricos que se unen a dos antígenos blanco diferentes al mismo tiempo. En una modalidad, los anticuerpos heterodiméricos son anticuerpos biespecíficos. En una modalidad, los anticuerpos heterodiméricos comprenden tres polipéptidos que incluyen: un primer polipéptido que comprende un polipéptido de fusión scFv-Fc; un segundo polipéptido que comprende una cadena pesada de inmunoglobulina; y un tercer polipéptido que comprende una cadena ligera de inmunoglobulina. En una modalidad, el primer polipéptido incluye una o más mutaciones puntuales que confieren una mayor estabilidad térmica al primer polipéptido.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962869343P | 2019-07-01 | 2019-07-01 | |
US201962890163P | 2019-08-22 | 2019-08-22 | |
US201962945350P | 2019-12-09 | 2019-12-09 | |
PCT/US2020/040360 WO2021003189A1 (en) | 2019-07-01 | 2020-06-30 | Heterodimeric antibodies that bind to cd38 and cd3 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021016066A true MX2021016066A (es) | 2022-05-18 |
Family
ID=74100698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021016066A MX2021016066A (es) | 2019-07-01 | 2020-06-30 | Anticuerpos heterodimericos que se unen a cd38 y cd3. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220363758A1 (es) |
EP (1) | EP3993831A1 (es) |
JP (1) | JP2022538461A (es) |
KR (1) | KR20220030276A (es) |
CN (1) | CN114340668A (es) |
AU (1) | AU2020301003A1 (es) |
CA (1) | CA3144961A1 (es) |
IL (1) | IL289497A (es) |
MX (1) | MX2021016066A (es) |
WO (1) | WO2021003189A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024513238A (ja) * | 2021-04-09 | 2024-03-22 | ソレント・セラピューティクス・インコーポレイテッド | 抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス |
CA3226428A1 (en) * | 2021-08-02 | 2023-02-09 | Hangzhou Unogen Biotech, Ltd | Anti-cd38 antibodies, anti-cd3 antibodies, and bispecific antibodies, and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7381803B1 (en) * | 1992-03-27 | 2008-06-03 | Pdl Biopharma, Inc. | Humanized antibodies against CD3 |
KR102391731B1 (ko) * | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
TN2017000222A1 (en) * | 2014-11-26 | 2018-10-19 | Xencor Inc | Heterodimeric antibodies that bind cd3 and cd38 |
US20180305465A1 (en) * | 2015-11-25 | 2018-10-25 | Amgen Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
CA3080109A1 (en) * | 2017-11-03 | 2019-05-09 | Sorrento Therapeutics, Inc. | Cd38-directed chimeric antigen receptor constructs |
-
2020
- 2020-06-30 US US17/622,087 patent/US20220363758A1/en not_active Abandoned
- 2020-06-30 EP EP20834912.6A patent/EP3993831A1/en not_active Withdrawn
- 2020-06-30 WO PCT/US2020/040360 patent/WO2021003189A1/en unknown
- 2020-06-30 MX MX2021016066A patent/MX2021016066A/es unknown
- 2020-06-30 CA CA3144961A patent/CA3144961A1/en active Pending
- 2020-06-30 JP JP2021578022A patent/JP2022538461A/ja active Pending
- 2020-06-30 CN CN202080061429.5A patent/CN114340668A/zh active Pending
- 2020-06-30 KR KR1020227003619A patent/KR20220030276A/ko unknown
- 2020-06-30 AU AU2020301003A patent/AU2020301003A1/en active Pending
-
2021
- 2021-12-29 IL IL289497A patent/IL289497A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3993831A1 (en) | 2022-05-11 |
IL289497A (en) | 2022-02-01 |
CN114340668A (zh) | 2022-04-12 |
JP2022538461A (ja) | 2022-09-02 |
CA3144961A1 (en) | 2021-01-07 |
US20220363758A1 (en) | 2022-11-17 |
AU2020301003A1 (en) | 2022-02-17 |
WO2021003189A1 (en) | 2021-01-07 |
KR20220030276A (ko) | 2022-03-10 |
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