PE20240327A1 - Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr - Google Patents
Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfrInfo
- Publication number
- PE20240327A1 PE20240327A1 PE2023002849A PE2023002849A PE20240327A1 PE 20240327 A1 PE20240327 A1 PE 20240327A1 PE 2023002849 A PE2023002849 A PE 2023002849A PE 2023002849 A PE2023002849 A PE 2023002849A PE 20240327 A1 PE20240327 A1 PE 20240327A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally substituted
- alkyl
- halo
- hydrogen
- alkoxy
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 title abstract 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 title abstract 2
- 230000035772 mutation Effects 0.000 title abstract 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 title abstract 2
- -1 AMINO Chemical group 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de Formula (I-i) o una sal farmaceuticamente aceptable, un estereoisomero o un tautomero de estos, en donde: s es 0, 1 o 2; t es 1 o 2; el anillo es un arilo de 6 a 10 miembros o un heteroarilo de 5 a 10 miembros; R1 es alquilo C1-5, haloalquilo C1-5, alquenilo C2-5, alquinilo C2-5 o heterociclilo de 3 a 6, entre otros; Ra es halo, CN, N(Rn1)2, alquilo C1-5 opcionalmente sustituido, -O-alquilo C1-5 opcionalmente sustituido, -O-alquileno C1-5-O-alquilo C1-5 opcionalmente sustituido, -CO2-alquilo C1-5 opcionalmente sustituido, o un heterociclilo de 3 a 6 opcionalmente sustituido; cada instancia de Rn1 es hidrogeno o alquilo C1-5; J es NRb y X1 es CH; o J es un enlace y X1 es N; s es 0, 1 o 2; t es 1 o 2; Rb es hidrogeno o alquilo C1-5 opcionalmente sustituido; R2 es alquilo C1-5 opcionalmente sustituido; o tomado junto con dos apariciones geminales de R2 forman un resto oxo; o dos apariciones no geminales de R2 tomadas juntas forman un puente alquileno C1-4; n es 0 o un numero entero de 1 a 3, inclusive, segun permita la valencia; U es CRc o N; V es CRd o N; siempre que al menos uno de U y V sea N; Rc es hidrogeno, halo o alcoxi C1-5 opcionalmente sustituido; Rd es hidrogeno, halo, alquilo C1-5 opcionalmente sustituido, o alcoxi C1-5 opcionalmente sustituido, o Rd y una aparicion de R2 tomados junto con los atomos intervinientes forman un anillo heterociclico de 5 a 6 miembros; W es N o CRe; Re es hidrogeno, halo o ciano; Y1 e Y2 son, cada uno, independientemente CH, CR4 o N, siempre que al menos uno de Y1 e Y2 sea CH o CR4; R4, independientemente para cada aparicion, es halo, alquilo C1-5 opcionalmente sustituido o alcoxi C1-5 opcionalmente sustituido; m es 0 o un numero entero de 1 a 4, inclusive, segun permita la valencia; R5, independientemente para cada aparicion, es halo, alquilo C1-5 opcionalmente sustituido o alcoxi C1-5 opcionalmente sustituido; p es 0 o un numero entero de 1 a 3, inclusive, segun permita la valencia, dichos compuestos son para tratar canceres con mutaciones de EGFR.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163174177P | 2021-04-13 | 2021-04-13 | |
| US202163239089P | 2021-08-31 | 2021-08-31 | |
| US202163242837P | 2021-09-10 | 2021-09-10 | |
| US202163292605P | 2021-12-22 | 2021-12-22 | |
| PCT/US2022/024334 WO2022221227A1 (en) | 2021-04-13 | 2022-04-12 | Amino-substituted heterocycles for treating cancers with egfr mutations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240327A1 true PE20240327A1 (es) | 2024-02-22 |
Family
ID=81392726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002849A PE20240327A1 (es) | 2021-04-13 | 2022-04-12 | Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP4323356A1 (es) |
| JP (1) | JP2024516371A (es) |
| KR (1) | KR20230170039A (es) |
| AU (1) | AU2022257621A1 (es) |
| BR (1) | BR112023021111A2 (es) |
| CA (1) | CA3213079A1 (es) |
| CL (1) | CL2023003020A1 (es) |
| IL (1) | IL306100A (es) |
| MX (1) | MX2023012060A (es) |
| PE (1) | PE20240327A1 (es) |
| TW (1) | TW202309022A (es) |
| WO (1) | WO2022221227A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202214641A (zh) | 2020-06-30 | 2022-04-16 | 美商艾瑞生藥股份有限公司 | Ｈｅｒ２突變抑制劑 |
| WO2023081637A1 (en) | 2021-11-02 | 2023-05-11 | Enliven Therapeutics, Inc. | Fused tetracyclic quinazoline derivatives as inhibitors of erbb2 |
| CN117384162A (zh) * | 2022-05-17 | 2024-01-12 | 浙江文达医药科技有限公司 | 选择性her2抑制剂 |
| WO2024027695A1 (zh) * | 2022-08-04 | 2024-02-08 | 微境生物医药科技(上海)有限公司 | 作为her2抑制剂的化合物 |
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2022
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- 2022-04-12 IL IL306100A patent/IL306100A/en unknown
- 2022-04-12 WO PCT/US2022/024334 patent/WO2022221227A1/en active Application Filing
- 2022-04-12 TW TW111113881A patent/TW202309022A/zh unknown
- 2022-04-12 BR BR112023021111A patent/BR112023021111A2/pt unknown
- 2022-04-12 JP JP2023562688A patent/JP2024516371A/ja active Pending
- 2022-04-12 PE PE2023002849A patent/PE20240327A1/es unknown
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| KR20230170039A (ko) | 2023-12-18 |
| JP2024516371A (ja) | 2024-04-15 |
| US20220363696A1 (en) | 2022-11-17 |
| BR112023021111A2 (pt) | 2023-12-19 |
| EP4323356A1 (en) | 2024-02-21 |
| WO2022221227A1 (en) | 2022-10-20 |
| IL306100A (en) | 2023-11-01 |
| AU2022257621A1 (en) | 2023-11-23 |
| WO2022221227A9 (en) | 2023-11-30 |
| CA3213079A1 (en) | 2022-10-20 |
| CL2023003020A1 (es) | 2024-03-22 |
| MX2023012060A (es) | 2024-01-22 |
| TW202309022A (zh) | 2023-03-01 |
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