CL2023003020A1 - Heterociclos con sustitución amino para tratar cánceres con mutaciones de egfr - Google Patents

Heterociclos con sustitución amino para tratar cánceres con mutaciones de egfr

Info

Publication number
CL2023003020A1
CL2023003020A1 CL2023003020A CL2023003020A CL2023003020A1 CL 2023003020 A1 CL2023003020 A1 CL 2023003020A1 CL 2023003020 A CL2023003020 A CL 2023003020A CL 2023003020 A CL2023003020 A CL 2023003020A CL 2023003020 A1 CL2023003020 A1 CL 2023003020A1
Authority
CL
Chile
Prior art keywords
amino
treat cancers
egfr mutations
substituted heterocycles
compounds
Prior art date
Application number
CL2023003020A
Other languages
English (en)
Inventor
Baudouin Gerard
Joshua Courtney Horan
Scot Richard Mente
Henry Efrem Pelish
Matthew D Shair
Anupong Tangpeerachaikul
Kristin Lynne Andrews
Yuting Sun
Original Assignee
Nuvalent Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvalent Inc filed Critical Nuvalent Inc
Publication of CL2023003020A1 publication Critical patent/CL2023003020A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen compuestos heteroaromáticos con sustitución amino tales como 4-amino-quinazolinas, sales farmacéuticamente aceptables de los compuestos y composiciones farmacéuticas de estos. También se describen los métodos para tratar o prevenir el cáncer con los compuestos heteroaromáticos con sustitución amino, sales farmacéuticamente aceptables de los compuestos, y composiciones farmacéuticas de estos.
CL2023003020A 2021-04-13 2023-10-10 Heterociclos con sustitución amino para tratar cánceres con mutaciones de egfr CL2023003020A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163174177P 2021-04-13 2021-04-13
US202163239089P 2021-08-31 2021-08-31
US202163242837P 2021-09-10 2021-09-10
US202163292605P 2021-12-22 2021-12-22

Publications (1)

Publication Number Publication Date
CL2023003020A1 true CL2023003020A1 (es) 2024-03-22

Family

ID=81392726

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023003020A CL2023003020A1 (es) 2021-04-13 2023-10-10 Heterociclos con sustitución amino para tratar cánceres con mutaciones de egfr

Country Status (13)

Country Link
US (1) US12037346B2 (es)
EP (1) EP4323356A1 (es)
JP (1) JP2024516371A (es)
KR (1) KR20230170039A (es)
AU (1) AU2022257621A1 (es)
BR (1) BR112023021111A2 (es)
CA (1) CA3213079A1 (es)
CL (1) CL2023003020A1 (es)
IL (1) IL306100A (es)
MX (1) MX2023012060A (es)
PE (1) PE20240327A1 (es)
TW (1) TW202309022A (es)
WO (1) WO2022221227A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202214641A (zh) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Ｈｅｒ２突變抑制劑
WO2022221227A1 (en) * 2021-04-13 2022-10-20 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
WO2023081637A1 (en) 2021-11-02 2023-05-11 Enliven Therapeutics, Inc. Fused tetracyclic quinazoline derivatives as inhibitors of erbb2
CN117384162A (zh) * 2022-05-17 2024-01-12 浙江文达医药科技有限公司 选择性her2抑制剂
WO2024027695A1 (zh) * 2022-08-04 2024-02-08 微境生物医药科技(上海)有限公司 作为her2抑制剂的化合物

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