AR009435A1 - Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos. - Google Patents

Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos.

Info

Publication number
AR009435A1
AR009435A1 ARP970105802A AR009435A1 AR 009435 A1 AR009435 A1 AR 009435A1 AR P970105802 A ARP970105802 A AR P970105802A AR 009435 A1 AR009435 A1 AR 009435A1
Authority
AR
Argentina
Prior art keywords
substituted
derivative
alkyl group
inhibitor
lower alkyl
Prior art date
Application number
Other languages
English (en)
Original Assignee
Yamanouchi Pharma Co Ltd
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Merck Patent Gmbh filed Critical Yamanouchi Pharma Co Ltd
Publication of AR009435A1 publication Critical patent/AR009435A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Un derivado de guanidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor representado por la formula general (I) o una salfarmacéuticamente aceptable del mismo, el cual es util como inhibidor del intercambiador de Na+/H+ en la prevencion, tratamiento o diagnostico deenfermedades tales como la hipertension, la arritmia, la angina de pecho, la infartacion miocárdica, la arteriosclerosis, las complicaciones diabéticas ysimilares en las cuales está relacionado elintercambiador de Na+/H+. El derivado posee la formula (1) donde (2):R1 es un grupo arilo substituido con unsubstituyente seleccionado del grupo que consiste de un dialquilamino inferior- alquileno inferior-O-, un dialquilamino inferior-alquileno inferior-CONH-, unhetero anillo saturado conteniendo nitrogeno-CONH- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en el anillo y unhetero anillo saturado conteniendo un nitrogeno-alquileno inferior-O- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en elanillo, y un grupo de alquilo inferior que puede ser subtituido con un átomo de halogeno. R2: es un grupo alquilo inferior que puede estar sustituido con unátomo de halogeno.
ARP970105802 1996-12-16 1997-12-10 Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos. AR009435A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33563896 1996-12-16

Publications (1)

Publication Number Publication Date
AR009435A1 true AR009435A1 (es) 2000-04-12

Family

ID=18290844

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105802 AR009435A1 (es) 1996-12-16 1997-12-10 Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos.

Country Status (4)

Country Link
AR (1) AR009435A1 (es)
AU (1) AU5411998A (es)
WO (1) WO1998027061A1 (es)
ZA (1) ZA9711102B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1056729B1 (en) * 1998-02-27 2004-12-29 Pfizer Products Inc. N-[(substituted five-membered di- or triaza diunsaturated ring)carbonyl]guanidine derivatives for the treatment of ischemia
US6852733B2 (en) 2000-04-28 2005-02-08 Pfizer Inc. Sodium-hydrogen exchanger type 1 inhibitor
JP4716547B2 (ja) * 2000-08-10 2011-07-06 住友精化株式会社 ２−フェニルチアゾール類の製造方法
FR2842524B1 (fr) * 2002-07-16 2005-04-22 Aventis Pharma Sa Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments
CA2602336A1 (en) * 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
JP2009523748A (ja) * 2006-01-18 2009-06-25 シエナ ビオテク ソシエタ ペル アチオニ α７ニコチン性アセチルコリン受容体の調節物質およびそれらの治療への使用
KR100863336B1 (ko) * 2006-09-29 2008-10-15 한국화학연구원 신규 옥사졸-4-카르보닐구아니딘 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 허혈성 심장질환의 예방 및 치료용 약학적 조성물
KR100820173B1 (ko) * 2007-03-12 2008-04-08 한국화학연구원 4-메틸이미다졸-5-카보닐구아니딘 유도체, 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 허혈성 심장질환의 예방 및 치료용 약학적 조성물
LT2430921T (lt) 2007-04-03 2017-09-25 E. I. Du Pont De Nemours And Company Pakeistieji benzeno fungicidai
CN104271549B (zh) * 2012-05-03 2017-07-04 帝斯曼知识产权资产管理有限公司 一种新的制备维生素b6的中间体化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795808A (fr) * 1972-02-24 1973-08-22 Beecham Group Ltd Amidazoles polysubstitues
JPS63192755A (ja) * 1987-02-06 1988-08-10 Fujisawa Pharmaceut Co Ltd ２−フエニルアゾ−ル誘導体およびその塩
JPH0692375B2 (ja) * 1987-12-16 1994-11-16 四国化成工業株式会社 カルバモイルイミダゾールの合成方法
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
AU5411998A (en) 1998-07-15
WO1998027061A1 (fr) 1998-06-25
ZA9711102B (en) 1998-08-13

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