AR009435A1 - DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES. - Google Patents

DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES.

Info

Publication number
AR009435A1
AR009435A1 ARP970105802A AR009435A1 AR 009435 A1 AR009435 A1 AR 009435A1 AR P970105802 A ARP970105802 A AR P970105802A AR 009435 A1 AR009435 A1 AR 009435A1
Authority
AR
Argentina
Prior art keywords
substituted
derivative
alkyl group
inhibitor
lower alkyl
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Yamanouchi Pharma Co Ltd
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Merck Patent Gmbh filed Critical Yamanouchi Pharma Co Ltd
Publication of AR009435A1 publication Critical patent/AR009435A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Un derivado de guanidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor representado por la formula general (I) o una salfarmacéuticamente aceptable del mismo, el cual es util como inhibidor del intercambiador de Na+/H+ en la prevencion, tratamiento o diagnostico deenfermedades tales como la hipertension, la arritmia, la angina de pecho, la infartacion miocárdica, la arteriosclerosis, las complicaciones diabéticas ysimilares en las cuales está relacionado elintercambiador de Na+/H+. El derivado posee la formula (1) donde (2):R1 es un grupo arilo substituido con unsubstituyente seleccionado del grupo que consiste de un dialquilamino inferior- alquileno inferior-O-, un dialquilamino inferior-alquileno inferior-CONH-, unhetero anillo saturado conteniendo nitrogeno-CONH- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en el anillo y unhetero anillo saturado conteniendo un nitrogeno-alquileno inferior-O- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en elanillo, y un grupo de alquilo inferior que puede ser subtituido con un átomo de halogeno. R2: es un grupo alquilo inferior que puede estar sustituido con unátomo de halogeno.A guanidine derivative n- [carbonyl (5-membered heteroaryl-substituted)], an inhibitor represented by the general formula (I), or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of the Na + / H + exchanger in prevention , treatment or diagnosis of diseases such as hypertension, arrhythmia, angina pectoris, myocardial infarction, arteriosclerosis, diabetic and similar complications in which the Na + / H + exchanger is related. The derivative has the formula (1) where (2): R1 is an aryl group substituted with a substituent selected from the group consisting of a dialkylamino-lower alkylene-O-, a dialkylamino-lower alkylene-CONH-, a saturated ring hetero containing nitrogen-CONH- which can be substituted with a lower alkyl group on the ring nitrogen atom and a saturated ring hetero containing a nitrogen-lower alkylene-O- which can be substituted with a lower alkyl group on the nitrogen atom in ring, and a lower alkyl group that can be subtitled with a halogen atom. R2: is a lower alkyl group that can be substituted with a halogen atom.

ARP970105802 1996-12-16 1997-12-10 DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES. AR009435A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33563896 1996-12-16

Publications (1)

Publication Number Publication Date
AR009435A1 true AR009435A1 (en) 2000-04-12

Family

ID=18290844

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105802 AR009435A1 (en) 1996-12-16 1997-12-10 DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES.

Country Status (4)

Country Link
AR (1) AR009435A1 (en)
AU (1) AU5411998A (en)
WO (1) WO1998027061A1 (en)
ZA (1) ZA9711102B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA003603B1 (en) * 1998-02-27 2003-06-26 Пфайзер Продактс Инк. N-[(substituted five-membered di- or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
US6852733B2 (en) 2000-04-28 2005-02-08 Pfizer Inc. Sodium-hydrogen exchanger type 1 inhibitor
JP4716547B2 (en) * 2000-08-10 2011-07-06 住友精化株式会社 Method for producing 2-phenylthiazoles
FR2842524B1 (en) * 2002-07-16 2005-04-22 Aventis Pharma Sa PHARMACEUTICAL COMPOSITIONS CONTAINING 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE DERIVATIVE, PROCESS FOR PREPARING THE SAME AS MEDICAMENTS
WO2006103045A1 (en) * 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
JP2009523748A (en) * 2006-01-18 2009-06-25 シエナ ビオテク ソシエタ ペル アチオニ Modulators of α7 nicotinic acetylcholine receptors and their use in therapy
KR100863336B1 (en) * 2006-09-29 2008-10-15 한국화학연구원 Novel oxazol-4-yl-carbonylguanidine derivatives, pharmaceutically acceptable salt thereof, preparation method and a pharmaceutical composition for the prevention and treatment of ischemic heart diseases containing the same as an active ingredient
KR100820173B1 (en) * 2007-03-12 2008-04-08 한국화학연구원 4-methylimidazol-5-ylcarbonylguanidine derivatives, pharmaceutically acceptable salts thereof, preparation method, and pharmaceutical compositions for the prevention and treatment of the ischemic heart diseases containing the same as an active ingredient
EP2129225B1 (en) 2007-04-03 2012-12-05 E. I. Du Pont de Nemours and Company Substituted benzene fungicides
CN104271549B (en) * 2012-05-03 2017-07-04 帝斯曼知识产权资产管理有限公司 It is a kind of new to prepare vitamin B6Midbody compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795808A (en) * 1972-02-24 1973-08-22 Beecham Group Ltd AMIDAZOLES POLYSUBSTITUES
JPS63192755A (en) * 1987-02-06 1988-08-10 Fujisawa Pharmaceut Co Ltd 2-phenylazole derivative and salt thereof
JPH0692375B2 (en) * 1987-12-16 1994-11-16 四国化成工業株式会社 Method for synthesizing carbamoylimidazole
FR2665898B1 (en) * 1990-08-20 1994-03-11 Sanofi DERIVATIVES OF AMIDO-3 PYRAZOLE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
ZA9711102B (en) 1998-08-13
WO1998027061A1 (en) 1998-06-25
AU5411998A (en) 1998-07-15

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