UY23407A1 - PROCEDURE FOR THE PREPARATION OF SULFONAMIDES.- - Google Patents

PROCEDURE FOR THE PREPARATION OF SULFONAMIDES.-

Info

Publication number
UY23407A1
UY23407A1 UY23407A UY23407A UY23407A1 UY 23407 A1 UY23407 A1 UY 23407A1 UY 23407 A UY23407 A UY 23407A UY 23407 A UY23407 A UY 23407A UY 23407 A1 UY23407 A1 UY 23407A1
Authority
UY
Uruguay
Prior art keywords
preparation
sulfonamides
procedure
possibilities
vinylbenzenesulfonamide
Prior art date
Application number
UY23407A
Other languages
Spanish (es)
Inventor
Kaspar Burri
Martine Clozel
George Hirth
Henri Ramuz
Walter Fischil
Bernd-Michael Löffler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY23407A1 publication Critical patent/UY23407A1/en

Links

Abstract

La presente invención se refiere a un procedimiento para la preparación de compuestos de fórmula (I) (figuras 1) y sus sales en donde R4 significa, entre otras posibilidades, heteroarilo; R5 significa heterociclil-carbonilo, entre otras posibilidades. Como ejemplo no limitante: N-[5-(2,6-dimetoxibencil)-6-(3-hidroxipropil)-4-pirimidinil]-p-vinilbencensulfonamida. Pueden utilizarse como ingredientes activos para la preparación de medicamentos para el tratamiento de trastornos circulatorios, especialmente hipertensión, isquemia, vasospasmos y angina de pecho.The present invention relates to a process for the preparation of compounds of formula (I) (figures 1) and their salts in which R4 represents, among other possibilities, heteroaryl; R5 signifies heterocyclyl carbonyl, among other possibilities. As a non-limiting example: N- [5- (2,6-dimethoxybenzyl) -6- (3-hydroxypropyl) -4-pyrimidinyl] -p-vinylbenzenesulfonamide. They can be used as active ingredients for the preparation of drugs for the treatment of circulatory disorders, especially hypertension, ischemia, vasospasm and angina pectoris.

UY23407A 1991-04-25 1992-04-24 PROCEDURE FOR THE PREPARATION OF SULFONAMIDES.- UY23407A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH124291 1991-04-25

Publications (1)

Publication Number Publication Date
UY23407A1 true UY23407A1 (en) 1992-10-23

Family

ID=4205802

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23407A UY23407A1 (en) 1991-04-25 1992-04-24 PROCEDURE FOR THE PREPARATION OF SULFONAMIDES.-

Country Status (5)

Country Link
MX (1) MX9201912A (en)
RU (1) RU2083567C1 (en)
UY (1) UY23407A1 (en)
YU (1) YU48346B (en)
ZA (1) ZA922832B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2804162A1 (en) * 2010-07-13 2012-01-19 Astrazeneca Ab New crystalline forms of n-[2-[[(2,3-difluorophenyl)methyl]thio]-6-{[(1r,2s)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl}-1-azetidinesulfonamide
RU2461545C1 (en) * 2011-04-20 2012-09-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" (ФГУП "ГосНИИ "Кристалл") Method of producing 2-methylpyrimidine-4,6-(3h,5h)-dione

Also Published As

Publication number Publication date
YU43792A (en) 1995-01-31
MX9201912A (en) 1992-11-01
RU2083567C1 (en) 1997-07-10
YU48346B (en) 1998-07-10
ZA922832B (en) 1993-01-27

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20130715