FR2842524B1 - Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments - Google Patents

Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments

Info

Publication number
FR2842524B1
FR2842524B1 FR0208947A FR0208947A FR2842524B1 FR 2842524 B1 FR2842524 B1 FR 2842524B1 FR 0208947 A FR0208947 A FR 0208947A FR 0208947 A FR0208947 A FR 0208947A FR 2842524 B1 FR2842524 B1 FR 2842524B1
Authority
FR
France
Prior art keywords
guanidinocarbonyl
medicaments
heteroaryl
preparing
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0208947A
Other languages
English (en)
Other versions
FR2842524A1 (fr
Inventor
Baptiste Ronan
Jean Christophe Carry
Pascal Desmazeau
Serge Mignani
Jean Bouquerel
Borella Arielle Genevois
Heinz Werner Kleeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0208947A priority Critical patent/FR2842524B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to EP03763684A priority patent/EP1523480A2/fr
Priority to CA002492330A priority patent/CA2492330A1/fr
Priority to PCT/EP2003/007021 priority patent/WO2004007478A2/fr
Priority to JP2004520456A priority patent/JP4778229B2/ja
Priority to AU2003263167A priority patent/AU2003263167A1/en
Priority to MXPA05000046A priority patent/MXPA05000046A/es
Priority to BR0312702-8A priority patent/BR0312702A/pt
Priority to AR20030102527A priority patent/AR040563A1/es
Priority to TW092119092A priority patent/TW200413348A/zh
Priority to PE2003000700A priority patent/PE20040658A1/es
Priority to US10/745,909 priority patent/US7078414B2/en
Publication of FR2842524A1 publication Critical patent/FR2842524A1/fr
Priority to IL16609705A priority patent/IL166097A0/xx
Application granted granted Critical
Publication of FR2842524B1 publication Critical patent/FR2842524B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
FR0208947A 2002-07-16 2002-07-16 Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments Expired - Fee Related FR2842524B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR0208947A FR2842524B1 (fr) 2002-07-16 2002-07-16 Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments
BR0312702-8A BR0312702A (pt) 2002-07-16 2003-07-02 Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, processo de preparação e intermediários desse processo, seu uso como medicamentos e composições farmacêuticas compreendendo os mesmos
PCT/EP2003/007021 WO2004007478A2 (fr) 2002-07-16 2003-07-02 Derives de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, procede de preparation et intermediaires utilises dans ce procede, leurs utilisations en tant que medicaments et compositions pharmaceutiques les contenant
JP2004520456A JP4778229B2 (ja) 2002-07-16 2003-07-02 ３−グアニジノカルボニル−１−ヘテロアリール−ピロールの誘導体、製造方法および該方法の中間体、医薬としてのそれらの使用並びにそれらを含有する医薬組成物
AU2003263167A AU2003263167A1 (en) 2002-07-16 2003-07-02 Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, process for their preparation and their pharmaceutical use
MXPA05000046A MXPA05000046A (es) 2002-07-16 2003-07-02 Derivados de 3-guadinocarbonil-1-heteroaril-pirrol, procedimiento de preparacion e intermediarios de este procedimiento, su uso como medicamentos y composiciones farmaceuticas que los comprenden.
EP03763684A EP1523480A2 (fr) 2002-07-16 2003-07-02 Derives de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, procede de preparation et intermediaires utilises dans ce procede, leurs utilisations en tant que medicaments et compositions pharmaceutiques les contenant
CA002492330A CA2492330A1 (fr) 2002-07-16 2003-07-02 Derives de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, procede de preparation et intermediaires utilises dans ce procede, leurs utilisations en tant que medicaments et compositions pharmaceutiques les contenant
TW092119092A TW200413348A (en) 2002-07-16 2003-07-14 Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
AR20030102527A AR040563A1 (es) 2002-07-16 2003-07-14 Derivados de 3- guanidincarbonil - 1 heteroaril pirrol, procedimiento de preparacion e intermediarios de este procedimientosu, uso como medicamentos y composiciones farmaceuticas que los comprenden
PE2003000700A PE20040658A1 (es) 2002-07-16 2003-07-14 Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, procedimiento de preparacion e intermediarios de este procedimiento y composiciones farmaceuticas que los comprenden
US10/745,909 US7078414B2 (en) 2002-07-16 2003-12-23 Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
IL16609705A IL166097A0 (en) 2002-07-16 2005-01-02 Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole preparation process and intermediates of this process their use as medicaments and pharmaceutical compositions comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0208947A FR2842524B1 (fr) 2002-07-16 2002-07-16 Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments

Publications (2)

Publication Number Publication Date
FR2842524A1 FR2842524A1 (fr) 2004-01-23
FR2842524B1 true FR2842524B1 (fr) 2005-04-22

Family

ID=29797440

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0208947A Expired - Fee Related FR2842524B1 (fr) 2002-07-16 2002-07-16 Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments

Country Status (13)

Country Link
US (1) US7078414B2 (fr)
EP (1) EP1523480A2 (fr)
JP (1) JP4778229B2 (fr)
AR (1) AR040563A1 (fr)
AU (1) AU2003263167A1 (fr)
BR (1) BR0312702A (fr)
CA (1) CA2492330A1 (fr)
FR (1) FR2842524B1 (fr)
IL (1) IL166097A0 (fr)
MX (1) MXPA05000046A (fr)
PE (1) PE20040658A1 (fr)
TW (1) TW200413348A (fr)
WO (1) WO2004007478A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1654225A4 (fr) * 2003-08-13 2007-11-28 Amgen Inc Antagonistes du recepteur de l'hormone concentrant la melanine
CA2533112A1 (fr) * 2003-08-13 2005-03-03 Christopher Hulme Antagoniste du recepteur de l'hormone de concentration de la melanine
CN1856307A (zh) * 2003-09-23 2006-11-01 默克公司 喹啉钾通道抑制剂
BRPI0607404A2 (pt) * 2005-03-01 2009-09-01 Wyeth Corp compostos de cinolina e seu uso como moduladores de receptor de x hepático
EP1923387B1 (fr) * 2005-08-08 2011-10-19 Astellas Pharma Inc. Dérivé d'acylguanidine ou sel de celui-ci
US8222274B2 (en) * 2006-02-20 2012-07-17 Astellas Pharma Inc. Pyrrole derivative or salt thereof
EP1991540A1 (fr) * 2006-02-21 2008-11-19 Amgen Inc. Dérivés cinnoline comme inhibiteurs de phosphodiestérase 10
AU2007223801A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
JP5207964B2 (ja) 2006-03-31 2013-06-12 武田薬品工業株式会社 酸分泌抑制薬
WO2012007500A2 (fr) 2010-07-15 2012-01-19 Bayer Cropscience Ag Nouveaux composés hétérocycliques servant d'agents de lutte contre les nuisibles
US20130011480A1 (en) * 2011-05-05 2013-01-10 Rosenberg Mark A Cytotoxic therapy by proton flux modulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3162572B2 (ja) * 1993-04-28 2001-05-08 住友製薬株式会社 インドロイルグアニジン誘導体
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ZA9711102B (en) * 1996-12-16 1998-08-13 Yamanouchi Pharma Co Ltd N-[(substituted 5-membered heteroaryl)carbonyl] guanidine derivative
ID25505A (id) * 1998-02-27 2000-10-05 Pfizer Prod Inc Turunan-turunan n-karbonil (cincin ditakjenuh di-atau triaza beranggota lima tersubstitusi guanidina untuk pengobatan iskemia

Also Published As

Publication number Publication date
FR2842524A1 (fr) 2004-01-23
AR040563A1 (es) 2005-04-13
US20040266775A1 (en) 2004-12-30
EP1523480A2 (fr) 2005-04-20
MXPA05000046A (es) 2005-04-08
US7078414B2 (en) 2006-07-18
TW200413348A (en) 2004-08-01
WO2004007478A2 (fr) 2004-01-22
IL166097A0 (en) 2006-01-15
WO2004007478A3 (fr) 2004-02-19
AU2003263167A1 (en) 2004-02-02
PE20040658A1 (es) 2004-11-09
JP4778229B2 (ja) 2011-09-21
JP2005535668A (ja) 2005-11-24
BR0312702A (pt) 2005-04-26
CA2492330A1 (fr) 2004-01-22

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