CO2020013834A2 - Ciertos compuestos de pladienolida y métodos de uso - Google Patents
Ciertos compuestos de pladienolida y métodos de usoInfo
- Publication number
- CO2020013834A2 CO2020013834A2 CONC2020/0013834A CO2020013834A CO2020013834A2 CO 2020013834 A2 CO2020013834 A2 CO 2020013834A2 CO 2020013834 A CO2020013834 A CO 2020013834A CO 2020013834 A2 CO2020013834 A2 CO 2020013834A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- methods
- useful
- certain
- pladienolide compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000011374 additional therapy Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000001324 spliceosome Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
RESUMEN La presente divulgación proporciona compuestos de pladienolida novedosos, composiciones farmacéuticas que contienen dichos compuestos, y métodos para usar los compuestos como agentes terapéuticos. Estos compuestos pueden ser útiles en el tratamiento de cánceres, particularmente cánceres en los que se sabe que son útiles los agentes que se dirigen al espliceosoma y las mutaciones en el mismo. También se proporcionan en el presente documento métodos para tratar cánceres mediante la administración de al menos un compuesto divulgado en el presente documento y al menos una terapia adicional.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862655021P | 2018-04-09 | 2018-04-09 | |
US201862679653P | 2018-06-01 | 2018-06-01 | |
US201962814838P | 2019-03-06 | 2019-03-06 | |
US201962814843P | 2019-03-06 | 2019-03-06 | |
PCT/US2019/026313 WO2019199667A2 (en) | 2018-04-09 | 2019-04-08 | Certain pladienolide compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020013834A2 true CO2020013834A2 (es) | 2020-12-10 |
Family
ID=66248768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0013834A CO2020013834A2 (es) | 2018-04-09 | 2020-11-05 | Ciertos compuestos de pladienolida y métodos de uso |
Country Status (18)
Country | Link |
---|---|
US (1) | US11926619B2 (es) |
EP (1) | EP3774759A2 (es) |
JP (2) | JP7335265B2 (es) |
KR (1) | KR20210006907A (es) |
CN (1) | CN113166091A (es) |
AU (2) | AU2019251096B2 (es) |
BR (1) | BR112020020792A2 (es) |
CA (1) | CA3096400A1 (es) |
CL (3) | CL2020002604A1 (es) |
CO (1) | CO2020013834A2 (es) |
IL (2) | IL303335A (es) |
JO (2) | JOP20200242A1 (es) |
MX (2) | MX2020010606A (es) |
PE (1) | PE20212327A1 (es) |
PH (1) | PH12020500666A1 (es) |
SG (1) | SG11202009906TA (es) |
TW (1) | TW201945351A (es) |
WO (1) | WO2019199667A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023553588A (ja) | 2020-11-04 | 2023-12-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 骨髄異形成症候群(mds)のバイオマーカー及びその使用方法 |
WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
CN115414351B (zh) * | 2022-09-19 | 2024-05-17 | 山东大学齐鲁医院 | pladienolide B与PD-L1抗体组合在肿瘤免疫治疗领域的应用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
WO1997017614A1 (en) | 1995-11-10 | 1997-05-15 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
MXPA02001911A (es) | 1999-08-24 | 2003-07-21 | Medarex Inc | Anticuerpos ctla-4 humanos y sus usos. |
TWI312681B (en) | 2001-02-01 | 2009-08-01 | Novel physiologically active substance | |
TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
NZ537830A (en) | 2002-07-31 | 2007-12-21 | Mercian Corp | Novel physiologically active substances |
US7576204B2 (en) | 2002-07-31 | 2009-08-18 | Mercian Corporation | Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same |
AU2003285012A1 (en) | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
BR0316746A (pt) | 2002-11-29 | 2005-10-18 | Mercian Corp | Método de produção do composto macrolida 11107d, linhagem streptomyces sp.ab-1704 (ferm bp-8551), linhagem mortierella sp. f1529 (ferm bp-8547) ou linhagem f-1530 (ferm bp-8548), e linhagem ab-1896 (ferm bp-8550) |
EP1705247A4 (en) | 2003-11-27 | 2008-08-20 | Mercian Corp | DNA ACCOMPANYING HYDROXYLATION OF A MAKROLIDE COMPOUND |
EP1712642B1 (en) | 2004-02-06 | 2010-06-02 | Eisai R&D Management Co., Ltd. | Method of examining sensitivity of cancer cell to anticancer agent |
KR100834488B1 (ko) | 2004-07-20 | 2008-06-09 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 플라디에놀라이드의 생합성에 관여하는 폴리펩티드를코딩하는 dna |
WO2007110704A2 (en) * | 2005-09-28 | 2007-10-04 | Novimmune Sa | Macrolide compositions as therapeutic agent |
WO2007110705A2 (en) | 2005-09-28 | 2007-10-04 | Novimmune Sa | Macrolide as inhibitors of mhc class ii |
CN101282967B (zh) | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
JPWO2008020584A1 (ja) | 2006-08-14 | 2010-01-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定な凍結乾燥製剤 |
JPWO2008093853A1 (ja) | 2007-01-29 | 2010-05-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | マクロライド系化合物の固体およびその製造法並びにその医薬組成物 |
US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
EP2168961A1 (en) | 2007-07-06 | 2010-03-31 | Eisai R&D Management Co., Ltd. | Process for producing macrolide compound and intermediate therefor |
WO2013148324A1 (en) * | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Anti-cancer polyketide compounds |
SG10201700698WA (en) | 2012-05-15 | 2017-02-27 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
US20140275010A1 (en) * | 2013-03-12 | 2014-09-18 | Guo Zhu Zheng | Quaternary salts |
ME03417B (me) * | 2014-05-15 | 2020-01-20 | Eisai R&D Man Co Ltd | Jedinjenje pladienolid piridina i postupci primjene |
CN106604933B (zh) | 2014-07-11 | 2021-08-10 | 文塔纳医疗系统公司 | 抗pd-l1抗体及其诊断用途 |
EP3910073B1 (en) | 2015-09-01 | 2024-03-06 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic sf3b1 mutants |
MX2018006155A (es) * | 2015-11-18 | 2018-08-01 | Eisai R&D Man Co Ltd | Una forma en estado solido de compuestos de pladienolida piridina y metodos de uso. |
MX2020012940A (es) | 2018-06-01 | 2021-03-25 | Eisai R&D Man Co Ltd | Metodos de uso de moduladores de empalme. |
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2019
- 2019-04-08 JP JP2020555130A patent/JP7335265B2/ja active Active
- 2019-04-08 WO PCT/US2019/026313 patent/WO2019199667A2/en unknown
- 2019-04-08 KR KR1020207032258A patent/KR20210006907A/ko unknown
- 2019-04-08 MX MX2020010606A patent/MX2020010606A/es unknown
- 2019-04-08 PE PE2020001558A patent/PE20212327A1/es unknown
- 2019-04-08 IL IL303335A patent/IL303335A/en unknown
- 2019-04-08 AU AU2019251096A patent/AU2019251096B2/en active Active
- 2019-04-08 EP EP19719036.6A patent/EP3774759A2/en active Pending
- 2019-04-08 IL IL277749A patent/IL277749B2/en unknown
- 2019-04-08 CN CN201980039253.0A patent/CN113166091A/zh active Pending
- 2019-04-08 CA CA3096400A patent/CA3096400A1/en active Pending
- 2019-04-08 SG SG11202009906TA patent/SG11202009906TA/en unknown
- 2019-04-08 BR BR112020020792-6A patent/BR112020020792A2/pt unknown
- 2019-04-08 TW TW108112206A patent/TW201945351A/zh unknown
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- 2019-04-08 JO JOP/2020/0243A patent/JOP20200243A1/ar unknown
- 2019-04-08 US US17/045,952 patent/US11926619B2/en active Active
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2020
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- 2020-10-08 CL CL2020002604A patent/CL2020002604A1/es unknown
- 2020-11-05 CO CONC2020/0013834A patent/CO2020013834A2/es unknown
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2022
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2023
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- 2023-08-17 JP JP2023132865A patent/JP2023156456A/ja active Pending
- 2023-08-29 CL CL2023002549A patent/CL2023002549A1/es unknown
Also Published As
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CL2022000458A1 (es) | 2022-10-21 |
WO2019199667A2 (en) | 2019-10-17 |
CA3096400A1 (en) | 2019-10-17 |
JOP20200242A1 (ar) | 2020-09-29 |
JP2023156456A (ja) | 2023-10-24 |
TW201945351A (zh) | 2019-12-01 |
CL2020002604A1 (es) | 2021-01-15 |
MX2020010606A (es) | 2021-01-15 |
CL2023002549A1 (es) | 2024-01-26 |
CN113166091A (zh) | 2021-07-23 |
KR20210006907A (ko) | 2021-01-19 |
AU2019251096A1 (en) | 2020-11-26 |
PE20212327A1 (es) | 2021-12-14 |
IL303335A (en) | 2023-07-01 |
PH12020500666A1 (en) | 2021-07-26 |
IL277749A (en) | 2020-11-30 |
JOP20200243A1 (ar) | 2020-09-29 |
BR112020020792A2 (pt) | 2021-01-12 |
US11926619B2 (en) | 2024-03-12 |
WO2019199667A3 (en) | 2019-11-21 |
IL277749B1 (en) | 2023-07-01 |
AU2023202358A1 (en) | 2023-05-18 |
JP2021521124A (ja) | 2021-08-26 |
JP7335265B2 (ja) | 2023-08-29 |
AU2019251096B2 (en) | 2023-04-20 |
EP3774759A2 (en) | 2021-02-17 |
MX2022015216A (es) | 2023-01-04 |
US20210163456A1 (en) | 2021-06-03 |
SG11202009906TA (en) | 2020-11-27 |
IL277749B2 (en) | 2023-11-01 |
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