CO2019001967A2 - Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 - Google Patents

Compuestos de tiazolo-piridina sustituida como inhibidores de malt1

Info

Publication number
CO2019001967A2
CO2019001967A2 CONC2019/0001967A CO2019001967A CO2019001967A2 CO 2019001967 A2 CO2019001967 A2 CO 2019001967A2 CO 2019001967 A CO2019001967 A CO 2019001967A CO 2019001967 A2 CO2019001967 A2 CO 2019001967A2
Authority
CO
Colombia
Prior art keywords
thiazolo
substituted compounds
pyridine substituted
malt1 inhibitors
compounds
Prior art date
Application number
CONC2019/0001967A
Other languages
English (en)
Inventor
Gagan Kukreja
Nageswara Rao Irlapati
Arun Rangnath Jagdale
Gokul Keruji Deshmukh
Vinod Popatrao Vyavahare
Kiran Chandrashekhar Kulkarni
Neelima Sinha
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2017/054612 external-priority patent/WO2018020474A1/en
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of CO2019001967A2 publication Critical patent/CO2019001967A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuestos de fórmula general (I), en la que R1-R3 son como se definen en el presente documento, para su uso como inhibidores de MALT1 en el tratamiento de enfermedades o trastornos autoinmunes e inflamatorios. También se describen métodos para sintetizar los compuestos. También se describen composiciones farmacéuticas que contienen un compuesto de la invención y un método para tratar un paciente por una enfermedad o trastorno autoinmune o inflamatorio, por ejemplo, un cáncer, administrando un compuesto de la invención.
CONC2019/0001967A 2016-07-29 2019-02-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 CO2019001967A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201621026107 2016-07-29
IN201621043859 2016-12-22
IN201721009450 2017-03-17
PCT/IB2017/054612 WO2018020474A1 (en) 2016-07-29 2017-07-28 Substituted thiazolo-pyridine compounds as malt1 inhibitors

Publications (1)

Publication Number Publication Date
CO2019001967A2 true CO2019001967A2 (es) 2019-05-31

Family

ID=65656144

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0001967A CO2019001967A2 (es) 2016-07-29 2019-02-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1

Country Status (9)

Country Link
US (1) US20210052556A1 (es)
EP (2) EP3736277A1 (es)
BR (1) BR112019001824A2 (es)
CO (1) CO2019001967A2 (es)
CR (1) CR20190110A (es)
EC (1) ECSP19015143A (es)
IL (1) IL264465B (es)
MA (2) MA53299A (es)
RU (1) RU2021113671A (es)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US9051595B2 (en) 2007-06-01 2015-06-09 University Of Lausanne Malt1 specific cleavage in assay and screening method
ATE553769T1 (de) 2007-11-21 2012-05-15 Vib Vzw Inhibitoren der malt1-proteolytischen aktivität und ihre verwendung
PT2739285T (pt) 2011-08-02 2019-03-26 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Inibição seletiva da protease malt1 por meio de derivados de fenotiazina
WO2013053765A1 (en) 2011-10-11 2013-04-18 Proyecto De Biomedicina Cima, S.L. A non-human animal model of mucosa-associated lymphoid tissue (malt) lymphoma
EA201590916A1 (ru) 2012-11-09 2016-02-29 Корнэлл Юниверсити Низкомолекулярные ингибиторы malt1
WO2014086478A1 (en) 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
WO2014207067A1 (en) 2013-06-26 2014-12-31 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) The (s)-enantiomer of mepazine
US10502741B2 (en) 2014-01-21 2019-12-10 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umweld (GmbH) Means and methods for detecting activated MALT1
CA2945077A1 (en) 2014-05-28 2015-12-03 Novartis Ag Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors
DE102015210224A1 (de) 2015-06-02 2016-12-08 Universitätsklinikum Hamburg-Eppendorf Neuer wirkstoff zur behandlung von krebs
EP3341007B1 (en) 2015-08-28 2020-12-23 Cornell University Malt1 inhibitors and uses thereof
WO2017057695A1 (ja) 2015-09-30 2017-04-06 東レ株式会社 ジフェニルピラゾール誘導体及びその医薬用途
SG11201803480WA (en) 2015-11-13 2018-05-30 Novartis Ag Novel pyrazolo pyrimidine derivatives
JP7142022B2 (ja) * 2017-03-08 2022-09-26 コーネル・ユニバーシティー Ｍａｌｔ１の阻害剤およびそれらの使用

Also Published As

Publication number Publication date
CR20190110A (es) 2019-08-27
MA53299A (fr) 2022-02-23
IL264465A (en) 2019-02-28
EP3490995A1 (en) 2019-06-05
ECSP19015143A (es) 2019-05-31
RU2021113671A (ru) 2021-07-08
IL264465B (en) 2022-02-01
BR112019001824A2 (pt) 2019-05-07
EP3736277A1 (en) 2020-11-11
US20210052556A1 (en) 2021-02-25
MA45787A (fr) 2019-06-05

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