ATE553769T1 - Inhibitoren der malt1-proteolytischen aktivität und ihre verwendung - Google Patents
Inhibitoren der malt1-proteolytischen aktivität und ihre verwendungInfo
- Publication number
- ATE553769T1 ATE553769T1 AT08852880T AT08852880T ATE553769T1 AT E553769 T1 ATE553769 T1 AT E553769T1 AT 08852880 T AT08852880 T AT 08852880T AT 08852880 T AT08852880 T AT 08852880T AT E553769 T1 ATE553769 T1 AT E553769T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- see seq
- malt1 proteolytic
- proteolytic activity
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US409707P | 2007-11-21 | 2007-11-21 | |
EP07121200 | 2007-11-21 | ||
PCT/EP2008/065925 WO2009065897A2 (en) | 2007-11-21 | 2008-11-20 | Inhibitors of malt1 proteolytic activity and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE553769T1 true ATE553769T1 (de) | 2012-05-15 |
Family
ID=39186759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08852880T ATE553769T1 (de) | 2007-11-21 | 2008-11-20 | Inhibitoren der malt1-proteolytischen aktivität und ihre verwendung |
Country Status (6)
Country | Link |
---|---|
US (1) | US8309523B2 (de) |
EP (1) | EP2222326B2 (de) |
AT (1) | ATE553769T1 (de) |
AU (1) | AU2008327884B2 (de) |
CA (1) | CA2705694C (de) |
WO (1) | WO2009065897A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013541493A (ja) * | 2010-06-17 | 2013-11-14 | フュジアンス バイオメディカルズ インコーポレイテッド | 抗ウイルス剤として有用な化合物、組成物、及び使用の方法 |
EP2465928A1 (de) | 2010-12-16 | 2012-06-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Behandlung von Th17-vermittelten Krankheiten |
EP2744500A1 (de) | 2011-08-18 | 2014-06-25 | Nuhope LLC | Verbindungen zur verwendung in der krebstherapie |
WO2013053765A1 (en) | 2011-10-11 | 2013-04-18 | Proyecto De Biomedicina Cima, S.L. | A non-human animal model of mucosa-associated lymphoid tissue (malt) lymphoma |
EP2879670A4 (de) * | 2012-08-01 | 2016-03-02 | Musc Found For Res Dev | Antibakterielle zusammensetzungen und verfahren |
US9651513B2 (en) * | 2012-10-14 | 2017-05-16 | Synaptics Incorporated | Fingerprint sensor and button combinations and methods of making same |
MX2015005744A (es) | 2012-11-09 | 2016-02-10 | Univ Cornell | Inhibidores de malti de molecula pequeña. |
LT3149001T (lt) * | 2014-05-28 | 2019-08-12 | Novartis Ag | Naujieji pirazolo pirimidino dariniai ir jų panaudojimas kaip malt1 inhibitorių |
CN108473499B (zh) | 2015-11-13 | 2021-07-23 | 诺华股份有限公司 | 新颖的吡唑并嘧啶衍生物 |
CN105541806A (zh) * | 2015-12-25 | 2016-05-04 | 中国药科大学 | 巴比妥酸类化合物、制备方法及其应用 |
EP3736277A1 (de) | 2016-07-29 | 2020-11-11 | Lupin Limited | Substituierte thiazolpyridinverbindungen als malt1-inhibitoren |
JP6927042B2 (ja) * | 2016-07-29 | 2021-08-25 | 東レ株式会社 | グアニジン誘導体及びその医薬用途 |
CA3032334A1 (en) * | 2016-07-29 | 2018-02-01 | Lupin Limited | Substituted thiazolo-pyridine compounds as malt1 inhibitors |
TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為malt1抑制劑之吡唑衍生物 |
AU2020293522B2 (en) * | 2019-06-13 | 2024-01-25 | Shanghai Kechow Pharma, Inc. | Use of aminothiol compounds as cerebral nerve or heart protective agent |
EP4081526A1 (de) * | 2019-12-27 | 2022-11-02 | Schrödinger, Inc. | Cyclische verbindungen und verfahren zur verwendung davon |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001055390A1 (en) * | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
GB0013655D0 (en) * | 2000-06-05 | 2000-07-26 | Prolifix Ltd | Therapeutic compounds |
WO2003074497A1 (en) * | 2002-03-01 | 2003-09-12 | Pintex Pharmaceutical, Inc. | Pin1-modulating compounds and methods of use thereof |
US20040110145A1 (en) * | 2002-12-09 | 2004-06-10 | Isis Pharmaceuticals Inc. | Modulation of MALT1 expression |
US20070203236A1 (en) * | 2006-01-11 | 2007-08-30 | Smith Jeffrey W | Novel antagonists of the human fatty acid synthase thioesterase |
EP2153231B1 (de) † | 2007-06-01 | 2013-05-15 | University of Lausanne | Malz-1-spezifische spaltung in assay und screening-verfahren |
-
2008
- 2008-11-20 CA CA2705694A patent/CA2705694C/en not_active Expired - Fee Related
- 2008-11-20 EP EP08852880.7A patent/EP2222326B2/de not_active Not-in-force
- 2008-11-20 AT AT08852880T patent/ATE553769T1/de active
- 2008-11-20 US US12/734,651 patent/US8309523B2/en active Active
- 2008-11-20 AU AU2008327884A patent/AU2008327884B2/en not_active Ceased
- 2008-11-20 WO PCT/EP2008/065925 patent/WO2009065897A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20110021548A1 (en) | 2011-01-27 |
CA2705694C (en) | 2015-02-24 |
AU2008327884A1 (en) | 2009-05-28 |
EP2222326B1 (de) | 2012-04-18 |
EP2222326A2 (de) | 2010-09-01 |
US8309523B2 (en) | 2012-11-13 |
WO2009065897A3 (en) | 2010-09-23 |
WO2009065897A2 (en) | 2009-05-28 |
CA2705694A1 (en) | 2009-05-28 |
AU2008327884B2 (en) | 2013-01-24 |
EP2222326B2 (de) | 2015-02-25 |
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