CY1123059T1 - Αναστολη του διαυλου ιοντων παροδικου δυναμικου του υποδοχεα α1 - Google Patents
Αναστολη του διαυλου ιοντων παροδικου δυναμικου του υποδοχεα α1Info
- Publication number
- CY1123059T1 CY1123059T1 CY20201100485T CY201100485T CY1123059T1 CY 1123059 T1 CY1123059 T1 CY 1123059T1 CY 20201100485 T CY20201100485 T CY 20201100485T CY 201100485 T CY201100485 T CY 201100485T CY 1123059 T1 CY1123059 T1 CY 1123059T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ion channel
- channel inhibition
- receptor
- transient ion
- receptor transient
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Discharging, Photosensitive Material Shape In Electrophotography (AREA)
- Electrotherapy Devices (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε φαρμακευτικές ενώσεις Τύπου (Ι) ή ένα φαρμακευτικά αποδεκτό άλας ή σύνθεση αυτών και σε μεθόδους χρήσης τους για την αγωγή του άλγους, αναπνευστικών παθήσεων καθώς επίσης και για την αναστολή του διαύλου ιόντων Παροδικού Δυναμικού του Υποδοχέα Α1 (TRPA1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462052678P | 2014-09-19 | 2014-09-19 | |
PCT/US2015/051063 WO2016044792A1 (en) | 2014-09-19 | 2015-09-18 | Inhibiting the transient receptor potential a1 ion channel |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123059T1 true CY1123059T1 (el) | 2021-10-29 |
Family
ID=54249631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100485T CY1123059T1 (el) | 2014-09-19 | 2020-05-28 | Αναστολη του διαυλου ιοντων παροδικου δυναμικου του υποδοχεα α1 |
Country Status (18)
Country | Link |
---|---|
US (2) | US10221177B2 (el) |
EP (1) | EP3193880B1 (el) |
JP (4) | JP6571173B2 (el) |
CN (1) | CN106715430B (el) |
AU (1) | AU2015317332B2 (el) |
CA (1) | CA2961412C (el) |
CY (1) | CY1123059T1 (el) |
DK (1) | DK3193880T3 (el) |
ES (1) | ES2788395T3 (el) |
HR (1) | HRP20200601T1 (el) |
HU (1) | HUE049253T2 (el) |
LT (1) | LT3193880T (el) |
PL (1) | PL3193880T3 (el) |
PT (1) | PT3193880T (el) |
RS (1) | RS60192B1 (el) |
SI (1) | SI3193880T1 (el) |
TW (1) | TWI704149B (el) |
WO (1) | WO2016044792A1 (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI676626B (zh) * | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位a1離子通道 |
PL3193880T3 (pl) * | 2014-09-19 | 2020-09-07 | Eli Lilly And Company | Hamowanie kanału jonowego receptora przejściowego potencjału A1 |
JP6511692B2 (ja) * | 2015-05-20 | 2019-05-15 | グアンドン レイノベント バイオテック カンパニー リミテッド | ヒドロキシプリン類化合物及びその応用 |
CN107614501B (zh) | 2015-05-20 | 2020-01-14 | 广东众生睿创生物科技有限公司 | 羟基嘌呤类化合物及其应用 |
TWI690529B (zh) * | 2015-05-20 | 2020-04-11 | 大陸商廣東衆生睿創生物科技有限公司 | 羥基嘌呤類化合物及其應用 |
TWI690526B (zh) * | 2015-05-20 | 2020-04-11 | 大陸商廣東衆生睿創生物科技有限公司 | 羥基嘌呤類化合物及其應用 |
EP3554500A1 (en) * | 2016-12-16 | 2019-10-23 | Galderma Research & Development | Trpa1 antagonists for use in the treatment of atopic dermatitis |
EP3746445A1 (en) * | 2018-01-31 | 2020-12-09 | Eli Lilly And Company | Inhibiting the transient receptor potential a1 ion channel |
CN114502540A (zh) | 2019-05-31 | 2022-05-13 | 医肯纳肿瘤学公司 | Tead抑制剂和其用途 |
US10582716B1 (en) | 2019-06-14 | 2020-03-10 | Lennham Pharmaceuticals, Inc. | Deuterated caffeine and uses thereof |
FR3114235A1 (fr) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer |
IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
KR20230027841A (ko) | 2021-08-20 | 2023-02-28 | 주식회사 엘지에너지솔루션 | 충방전 전력 제어 장치, 에너지 저장 시스템 및 에너지 저장 시스템의 동작 방법 |
WO2023133502A1 (en) * | 2022-01-07 | 2023-07-13 | The Johns Hopkins University | Treatment and prevention of trigeminal neuralgia |
CN114671876B (zh) * | 2022-04-27 | 2023-10-03 | 成都施贝康生物医药科技有限公司 | 新型茶碱类化合物、异构体或盐及其制备方法和用途 |
CN116655635B (zh) * | 2023-05-19 | 2024-01-26 | 济南爱思医药科技有限公司 | 黑茶茶碱衍生物及在制备药物中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006327181A1 (en) | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | TRPA1 inhibitors for treating pain |
SI3184527T1 (sl) * | 2007-06-22 | 2020-03-31 | Eli Lilly And Company | Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala |
WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
WO2010036821A1 (en) * | 2008-09-24 | 2010-04-01 | Hydra Biosciences, Inc. | Methods and compositions for treating respiratory disorders |
AR087501A1 (es) | 2011-08-09 | 2014-03-26 | Hydra Biosciences Inc | Compuestos inhibidores del canal ionico del potencial receptor transitorio trpa1 |
TW201441225A (zh) | 2013-01-18 | 2014-11-01 | Cubist Pharm Inc | 瞬時受體電位a1離子通道之抑制 |
GB201309333D0 (en) * | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
TWI676626B (zh) | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位a1離子通道 |
PL3193880T3 (pl) * | 2014-09-19 | 2020-09-07 | Eli Lilly And Company | Hamowanie kanału jonowego receptora przejściowego potencjału A1 |
-
2015
- 2015-09-18 PL PL15774806T patent/PL3193880T3/pl unknown
- 2015-09-18 JP JP2017515082A patent/JP6571173B2/ja active Active
- 2015-09-18 SI SI201531172T patent/SI3193880T1/sl unknown
- 2015-09-18 RS RS20200488A patent/RS60192B1/sr unknown
- 2015-09-18 ES ES15774806T patent/ES2788395T3/es active Active
- 2015-09-18 CN CN201580050404.4A patent/CN106715430B/zh active Active
- 2015-09-18 WO PCT/US2015/051063 patent/WO2016044792A1/en active Application Filing
- 2015-09-18 AU AU2015317332A patent/AU2015317332B2/en active Active
- 2015-09-18 CA CA2961412A patent/CA2961412C/en active Active
- 2015-09-18 LT LTEP15774806.2T patent/LT3193880T/lt unknown
- 2015-09-18 US US15/512,213 patent/US10221177B2/en active Active
- 2015-09-18 HU HUE15774806A patent/HUE049253T2/hu unknown
- 2015-09-18 EP EP15774806.2A patent/EP3193880B1/en active Active
- 2015-09-18 PT PT157748062T patent/PT3193880T/pt unknown
- 2015-09-18 DK DK15774806.2T patent/DK3193880T3/da active
- 2015-09-21 TW TW104131124A patent/TWI704149B/zh active
-
2018
- 2018-12-28 US US16/234,809 patent/US10519158B2/en active Active
-
2019
- 2019-08-07 JP JP2019145414A patent/JP2019206577A/ja active Pending
-
2020
- 2020-04-16 HR HRP20200601TT patent/HRP20200601T1/hr unknown
- 2020-05-28 CY CY20201100485T patent/CY1123059T1/el unknown
-
2021
- 2021-05-14 JP JP2021082039A patent/JP7181967B2/ja active Active
-
2022
- 2022-11-18 JP JP2022184500A patent/JP2023015338A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT3193880T (pt) | 2020-06-19 |
SI3193880T1 (sl) | 2020-06-30 |
US10221177B2 (en) | 2019-03-05 |
RS60192B1 (sr) | 2020-06-30 |
CN106715430B (zh) | 2019-09-17 |
WO2016044792A1 (en) | 2016-03-24 |
JP6571173B2 (ja) | 2019-09-04 |
DK3193880T3 (da) | 2020-06-02 |
EP3193880A1 (en) | 2017-07-26 |
JP2017528490A (ja) | 2017-09-28 |
EP3193880B1 (en) | 2020-03-25 |
JP2021120403A (ja) | 2021-08-19 |
ES2788395T3 (es) | 2020-10-21 |
LT3193880T (lt) | 2020-05-11 |
HRP20200601T1 (hr) | 2020-07-10 |
US20190330212A1 (en) | 2019-10-31 |
JP2023015338A (ja) | 2023-01-31 |
PL3193880T3 (pl) | 2020-09-07 |
AU2015317332B2 (en) | 2019-07-18 |
CA2961412A1 (en) | 2016-03-24 |
AU2015317332A1 (en) | 2017-03-16 |
CA2961412C (en) | 2024-01-16 |
US20170275285A1 (en) | 2017-09-28 |
HUE049253T2 (hu) | 2020-09-28 |
JP7181967B2 (ja) | 2022-12-01 |
TWI704149B (zh) | 2020-09-11 |
US10519158B2 (en) | 2019-12-31 |
CN106715430A (zh) | 2017-05-24 |
TW201625619A (zh) | 2016-07-16 |
JP2019206577A (ja) | 2019-12-05 |
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