EA201692114A1 - Замещенные дигидроизохинолиноновые соединения - Google Patents

Замещенные дигидроизохинолиноновые соединения

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Publication number
EA201692114A1
EA201692114A1 EA201692114A EA201692114A EA201692114A1 EA 201692114 A1 EA201692114 A1 EA 201692114A1 EA 201692114 A EA201692114 A EA 201692114A EA 201692114 A EA201692114 A EA 201692114A EA 201692114 A1 EA201692114 A1 EA 201692114A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
isohinoline
substituted dihydro
salts
dihydro
Prior art date
Application number
EA201692114A
Other languages
English (en)
Other versions
EA031892B1 (ru
Inventor
Майкл Рэймонд Коллинс
Роберт Стивен Каниа
Роберт Арнольд Кампф
Пэй-Пэй Кун
Дэниел Тайлер Ричтер
Скотт Чаннинг Саттон
Мартин Джеймс Уайтс
Original Assignee
Пфайзер Инк.
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Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201692114A1 publication Critical patent/EA201692114A1/ru
Publication of EA031892B1 publication Critical patent/EA031892B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к соединениям общей формулы (I), где R, R, R, R, L, X и Z являются такими, как определено в данном описании, и их фармацевтически приемлемым солям, к фармацевтическим композициям, содержащим такие соединения и соли, и к способам применения таких соединений, солей и композиций для лечения аномального клеточного роста, в том числе рака.
EA201692114A 2014-06-17 2015-06-05 Замещенные дигидроизохинолиноновые соединения для лечения аномального клеточного роста, ассоциированного с активностью ezh2 EA031892B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013410P 2014-06-17 2014-06-17
US201562156533P 2015-05-04 2015-05-04
PCT/IB2015/054272 WO2015193765A1 (en) 2014-06-17 2015-06-05 Substituted dihydroisoquinolinone compounds

Publications (2)

Publication Number Publication Date
EA201692114A1 true EA201692114A1 (ru) 2017-06-30
EA031892B1 EA031892B1 (ru) 2019-03-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692114A EA031892B1 (ru) 2014-06-17 2015-06-05 Замещенные дигидроизохинолиноновые соединения для лечения аномального клеточного роста, ассоциированного с активностью ezh2

Country Status (40)

Country Link
US (4) US9481666B2 (ru)
EP (2) EP3157915B1 (ru)
JP (1) JP6152495B1 (ru)
KR (1) KR101877187B1 (ru)
CN (1) CN107207464B (ru)
AP (1) AP2016009605A0 (ru)
AU (1) AU2015275826B2 (ru)
BR (1) BR112016029612B1 (ru)
CA (1) CA2894298C (ru)
CL (1) CL2016003246A1 (ru)
CR (2) CR20200484A (ru)
CU (1) CU24408B1 (ru)
CY (1) CY1121706T1 (ru)
DK (1) DK3157915T3 (ru)
EA (1) EA031892B1 (ru)
ES (1) ES2721031T3 (ru)
GE (1) GEP20186933B (ru)
HR (1) HRP20190604T1 (ru)
HU (1) HUE042964T2 (ru)
IL (1) IL248991B (ru)
LT (1) LT3157915T (ru)
MA (1) MA40225B1 (ru)
MD (1) MD4820C1 (ru)
ME (1) ME03419B (ru)
MX (1) MX2016016764A (ru)
MY (1) MY185765A (ru)
NZ (1) NZ726108A (ru)
PE (1) PE20161552A1 (ru)
PH (1) PH12016502378A1 (ru)
PL (1) PL3157915T3 (ru)
PT (1) PT3157915T (ru)
RS (1) RS58632B1 (ru)
SG (1) SG11201609386YA (ru)
SI (1) SI3157915T1 (ru)
SV (1) SV2016005333A (ru)
TN (1) TN2016000529A1 (ru)
TW (1) TWI561516B (ru)
UA (1) UA118380C2 (ru)
UY (1) UY36170A (ru)
WO (1) WO2015193765A1 (ru)

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EP3157915B1 (en) 2019-02-27
LT3157915T (lt) 2019-04-25
ES2721031T3 (es) 2019-07-26
EA031892B1 (ru) 2019-03-29
SI3157915T1 (sl) 2019-05-31
UA118380C2 (uk) 2019-01-10
SG11201609386YA (en) 2017-01-27
JP6152495B1 (ja) 2017-06-21
PT3157915T (pt) 2019-05-16
IL248991B (en) 2020-02-27
EP3157915A1 (en) 2017-04-26
CU20160180A7 (es) 2017-03-03
HRP20190604T1 (hr) 2019-05-31
CR20200484A (es) 2021-04-26
MD20160136A2 (ru) 2017-05-31
CA2894298C (en) 2017-04-18
CL2016003246A1 (es) 2017-07-14
AU2015275826A1 (en) 2016-11-24
MY185765A (en) 2021-06-06
MX2016016764A (es) 2017-04-25
TW201609697A (zh) 2016-03-16
UY36170A (es) 2016-01-29
WO2015193765A1 (en) 2015-12-23
US20170298048A1 (en) 2017-10-19
MD4820B1 (ru) 2022-08-31
BR112016029612B1 (pt) 2021-01-19
MA40225A (fr) 2019-02-27
US20190040047A1 (en) 2019-02-07
ME03419B (me) 2020-01-20
CN107207464A (zh) 2017-09-26
PL3157915T3 (pl) 2019-07-31
RS58632B1 (sr) 2019-05-31
HUE042964T2 (hu) 2019-07-29
MD4820C1 (ru) 2023-03-31
CN107207464B (zh) 2019-10-22
BR112016029612A2 (pt) 2017-08-22
PE20161552A1 (es) 2017-01-11
US10570121B2 (en) 2020-02-25
SV2016005333A (es) 2017-03-06
KR20170016493A (ko) 2017-02-13
DK3157915T3 (en) 2019-04-23
CU24408B1 (es) 2019-05-03
US20160376254A1 (en) 2016-12-29
IL248991A0 (en) 2017-01-31
KR101877187B1 (ko) 2018-07-10
NZ726108A (en) 2020-06-26
PH12016502378A1 (en) 2017-02-20
AU2015275826B2 (en) 2019-05-16
US20150361067A1 (en) 2015-12-17
CR20160574A (es) 2017-02-23
JP2017519013A (ja) 2017-07-13
AP2016009605A0 (en) 2016-12-31
MA40225B1 (fr) 2019-05-31
CY1121706T1 (el) 2020-07-31
EP3521285A1 (en) 2019-08-07
TN2016000529A1 (en) 2018-04-04
US9481666B2 (en) 2016-11-01
CA2894298A1 (en) 2015-12-17
GEP20186933B (en) 2018-12-10
TWI561516B (en) 2016-12-11

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