MX2021005924A - Compuestos y metodos de uso de los mismos para el tratamiento del cancer. - Google Patents

Compuestos y metodos de uso de los mismos para el tratamiento del cancer.

Info

Publication number
MX2021005924A
MX2021005924A MX2021005924A MX2021005924A MX2021005924A MX 2021005924 A MX2021005924 A MX 2021005924A MX 2021005924 A MX2021005924 A MX 2021005924A MX 2021005924 A MX2021005924 A MX 2021005924A MX 2021005924 A MX2021005924 A MX 2021005924A
Authority
MX
Mexico
Prior art keywords
sup
compounds
methods
cancer
treatment
Prior art date
Application number
MX2021005924A
Other languages
English (en)
Inventor
Yuan Liu
Pingda Ren
Yi Liu
Liansheng Li
Tao Wu
Original Assignee
Araxes Pharma Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Araxes Pharma Llc filed Critical Araxes Pharma Llc
Publication of MX2021005924A publication Critical patent/MX2021005924A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Abstract

Se proporcionan compuestos que tienen actividad como inhibidores de la proteína KRAS mutante G12C. Los compuestos tienen la siguiente estructura (I): (ver Fórmula) o una sal, estereoisómero, forma isotópica o profármaco farmacéuticamente aceptable de los mismos, en donde A, B, R1, R3, L1, L2, L3, E, A1, A2, A3, A4, G1, G2, W, X, Y, Z, m1, m2, n1 y n2 son como se definen en el presente documento. También se proporcionan métodos asociados con la preparación y uso de esos compuestos, composiciones farmacéuticas que comprenden esos compuestos y métodos para modular la actividad de la proteína KRAS mutante G12C para el tratamiento de trastornos, tales como cáncer.
MX2021005924A 2018-11-29 2019-11-27 Compuestos y metodos de uso de los mismos para el tratamiento del cancer. MX2021005924A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862773104P 2018-11-29 2018-11-29
US201862773084P 2018-11-29 2018-11-29
PCT/US2019/063702 WO2020113071A1 (en) 2018-11-29 2019-11-27 Compounds and methods of use thereof for treatment of cancer

Publications (1)

Publication Number Publication Date
MX2021005924A true MX2021005924A (es) 2021-06-30

Family

ID=68966062

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021005924A MX2021005924A (es) 2018-11-29 2019-11-27 Compuestos y metodos de uso de los mismos para el tratamiento del cancer.

Country Status (10)

Country Link
US (1) US20220112192A1 (es)
EP (1) EP3887373A1 (es)
JP (1) JP2022509830A (es)
KR (1) KR20210097715A (es)
CN (1) CN113227092A (es)
AU (1) AU2019388998A1 (es)
BR (1) BR112021010454A2 (es)
CA (1) CA3120383A1 (es)
MX (1) MX2021005924A (es)
WO (1) WO2020113071A1 (es)

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US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
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Also Published As

Publication number Publication date
KR20210097715A (ko) 2021-08-09
CN113227092A (zh) 2021-08-06
AU2019388998A1 (en) 2021-06-03
WO2020113071A1 (en) 2020-06-04
EP3887373A1 (en) 2021-10-06
US20220112192A1 (en) 2022-04-14
JP2022509830A (ja) 2022-01-24
BR112021010454A2 (pt) 2021-08-24
CA3120383A1 (en) 2020-06-04

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