WO2008153042A1 - 抗腫瘍剤 - Google Patents
抗腫瘍剤 Download PDFInfo
- Publication number
- WO2008153042A1 WO2008153042A1 PCT/JP2008/060651 JP2008060651W WO2008153042A1 WO 2008153042 A1 WO2008153042 A1 WO 2008153042A1 JP 2008060651 W JP2008060651 W JP 2008060651W WO 2008153042 A1 WO2008153042 A1 WO 2008153042A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituent
- hydrogen atom
- tumor agent
- aryl
- prodrug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
式(I) [式中、R1は置換基を有していてもよいアリール等を表し、
R2はシアノ等を表し、R3は水素原子を表し、R4は水素原子、置換基を有していてもよい低級アルカノイル等を表し、R5は置換基を有していてもよいアリールまたは置換基を有していてもよい芳香族複素環基を表し、Xは-NR9-(式中、R9は水素原子、置換基を有していてもよい低級アルキルまたは置換基を有していてもよい低級アルコキシカルボニルを表す)または-S(O)n-(式中、nは0から2の整数を表す)を表す]で表されるピラゾール誘導体もしくはそのプロドラッグまたはその薬学的に許容される塩を有効成分として含有する抗腫瘍剤等を提供する。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007153800 | 2007-06-11 | ||
JP2007-153800 | 2007-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008153042A1 true WO2008153042A1 (ja) | 2008-12-18 |
Family
ID=40129647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/060651 WO2008153042A1 (ja) | 2007-06-11 | 2008-06-11 | 抗腫瘍剤 |
Country Status (2)
Country | Link |
---|---|
TW (1) | TW200911240A (ja) |
WO (1) | WO2008153042A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011529891A (ja) * | 2008-07-31 | 2011-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | Janusキナーゼの阻害剤 |
EP2467142A2 (en) * | 2009-08-17 | 2012-06-27 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
WO2014053450A1 (de) | 2012-10-02 | 2014-04-10 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
WO2015031036A1 (en) * | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
WO2015042086A1 (en) | 2013-09-18 | 2015-03-26 | The Procter & Gamble Company | Laundry care composition comprising carboxylate dye |
WO2015041887A2 (en) | 2013-09-18 | 2015-03-26 | Milliken & Company | Laundry care composition comprising carboxylate dye |
WO2015150300A1 (de) | 2014-04-02 | 2015-10-08 | Bayer Cropscience Ag | N-(1-(hetero)aryl-1h-pyrazol-4-yl)-(hetero)arylamid-derivate und ihre verwendung als schädlingsbekämpfungsmittel |
JP2016037462A (ja) * | 2014-08-07 | 2016-03-22 | 長谷川香料株式会社 | ソラノンの製造方法およびその合成中間体 |
US9878987B2 (en) | 2014-05-13 | 2018-01-30 | Memorial Sloan Kettering Cancer Center | HSP70 modulators and methods for making and using the same |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD267044A1 (de) * | 1987-12-01 | 1989-04-19 | Univ Rostock | Verfahren zur herstellung von pyrazolderivaten |
JPH0348243A (ja) * | 1989-07-17 | 1991-03-01 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
JPH11514991A (ja) * | 1995-09-29 | 1999-12-21 | ジー.ディー.サール アンド カンパニー | 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物 |
JP2000509035A (ja) * | 1996-04-24 | 2000-07-18 | セルテック セラピューティックス リミテッド | プロテインチロシンキナーゼp56ickの選択的インヒビターとして有用な5―アミノピラゾール化合物 |
JP2002502380A (ja) * | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼ阻害剤としてのピラゾール誘導体 |
JP2003500401A (ja) * | 1999-05-19 | 2003-01-07 | ファイザー・プロダクツ・インク | 抗がん剤として有用な複素環式誘導体 |
JP2006505512A (ja) * | 2002-07-24 | 2006-02-16 | キューエルティー インコーポレーティッド | ピラゾリルベンゾチアゾール誘導体および治療薬としてのそれらの使用法 |
-
2008
- 2008-06-11 WO PCT/JP2008/060651 patent/WO2008153042A1/ja active Application Filing
- 2008-06-11 TW TW097121742A patent/TW200911240A/zh unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD267044A1 (de) * | 1987-12-01 | 1989-04-19 | Univ Rostock | Verfahren zur herstellung von pyrazolderivaten |
JPH0348243A (ja) * | 1989-07-17 | 1991-03-01 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀写真感光材料 |
JPH11514991A (ja) * | 1995-09-29 | 1999-12-21 | ジー.ディー.サール アンド カンパニー | 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物 |
JP2000509035A (ja) * | 1996-04-24 | 2000-07-18 | セルテック セラピューティックス リミテッド | プロテインチロシンキナーゼp56ickの選択的インヒビターとして有用な5―アミノピラゾール化合物 |
JP2002502380A (ja) * | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼ阻害剤としてのピラゾール誘導体 |
JP2003500401A (ja) * | 1999-05-19 | 2003-01-07 | ファイザー・プロダクツ・インク | 抗がん剤として有用な複素環式誘導体 |
JP2006505512A (ja) * | 2002-07-24 | 2006-02-16 | キューエルティー インコーポレーティッド | ピラゾリルベンゾチアゾール誘導体および治療薬としてのそれらの使用法 |
Non-Patent Citations (6)
Title |
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ELGEMEIE G.H. ET AL.: "Novel cyanoketene N,S-acetals and pyrazole derivatives using potassium 2-cyanoethylene-1-thiolates", SYNTHETIC COMMUNICATIONS, vol. 37, no. 17, 2007, pages 2827 - 2834 * |
ELGEMEIE G.H. ET AL.: "Synthesis of benzimidazole ketene N,S-acetals and their reactions with nucleophiles", SYNTHETIC COMMUNICATIONS, vol. 33, no. 4, 2003, pages 555 - 562 * |
FATHALLA O.A. ET AL.: "Facile synthesis of fused pyrazolo[1,5-a]pyridimines, pyrazolo[1,5-a]triazines, and N-sulphonamidopyrazoles as antiinflammatory", ACTA POLONIAE PHARMACEUTICA, vol. 60, no. 1, 2003, pages 51 - 60 * |
KLUGE R. ET AL.: "Free radical reactions of N-heterocyclic compounds. XIV. Oxidative cyclization of anilinopyrazoles to pyrazolo[1,5-a]benzimidazoles", CHEMISCHE BERICHTE, vol. 127, no. 9, 1994, pages 1729 - 1733 * |
PERUMAL R. ET AL.: "Synthesis of 3-substituted N-substituted phenyl pyrazolo[3,4-d]pyrimidin-4-ones as antimicrobial agents", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15, no. 4, 2006, pages 413 - 414, XP008096899 * |
REDDY Y.S. ET AL.: "Synthesis and pharmacological activity of substituted pyrazoles", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 61, no. 1, 1999, pages 25 - 28 * |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011529891A (ja) * | 2008-07-31 | 2011-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | Janusキナーゼの阻害剤 |
US10052325B2 (en) | 2009-08-17 | 2018-08-21 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
EP3205647A3 (en) * | 2009-08-17 | 2017-09-27 | Memorial Sloan-Kettering Cancer Center | 2-(pyrimidin-5-yl)-thiopyrimidine derivatives as hsp70 and hsc70 modulators for the treatment of proliferative disorders |
US10758538B2 (en) | 2009-08-17 | 2020-09-01 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
EP2467142A2 (en) * | 2009-08-17 | 2012-06-27 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
US9567318B2 (en) | 2009-08-17 | 2017-02-14 | Memorial Sloan-Kettering Cancer Center | Substituted pyrimidine compounds and uses thereof |
EP2467142A4 (en) * | 2009-08-17 | 2013-03-06 | Sloan Kettering Inst Cancer | THERMAL SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING AND USING SAME |
WO2014053450A1 (de) | 2012-10-02 | 2014-04-10 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
WO2015031036A1 (en) * | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
US9884865B2 (en) | 2013-08-26 | 2018-02-06 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
US11180502B2 (en) | 2013-08-26 | 2021-11-23 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
JP2019031531A (ja) * | 2013-08-26 | 2019-02-28 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザスピロ[4.5]デカン誘導体及びその使用 |
CN105612152A (zh) * | 2013-08-26 | 2016-05-25 | 普渡制药公司 | 氮杂螺[4.5]癸烷衍生物及其用途 |
WO2015042086A1 (en) | 2013-09-18 | 2015-03-26 | The Procter & Gamble Company | Laundry care composition comprising carboxylate dye |
EP3339377A1 (en) | 2013-09-18 | 2018-06-27 | Milliken & Company | Laundry care composition comprising carboxylate dye |
WO2015041887A2 (en) | 2013-09-18 | 2015-03-26 | Milliken & Company | Laundry care composition comprising carboxylate dye |
EP4047058A1 (en) | 2013-09-18 | 2022-08-24 | Milliken & Company | Laundry care composition comprising a carboxylate dye |
WO2015150300A1 (de) | 2014-04-02 | 2015-10-08 | Bayer Cropscience Ag | N-(1-(hetero)aryl-1h-pyrazol-4-yl)-(hetero)arylamid-derivate und ihre verwendung als schädlingsbekämpfungsmittel |
US10160729B2 (en) | 2014-05-13 | 2018-12-25 | Memorial Sloan Kettering Cancer Center | Hsp70 modulators and methods for making and using the same |
US10647683B2 (en) | 2014-05-13 | 2020-05-12 | Memorial Sloan Kettering Cancer Center | Hsp70 modulators and methods for making and using the same |
US9878987B2 (en) | 2014-05-13 | 2018-01-30 | Memorial Sloan Kettering Cancer Center | HSP70 modulators and methods for making and using the same |
JP2016037462A (ja) * | 2014-08-07 | 2016-03-22 | 長谷川香料株式会社 | ソラノンの製造方法およびその合成中間体 |
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Publication number | Publication date |
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TW200911240A (en) | 2009-03-16 |
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