GT200000069A - Derivados heterociclicos utiles como agentes anticancerosos. - Google Patents
Derivados heterociclicos utiles como agentes anticancerosos.Info
- Publication number
- GT200000069A GT200000069A GT200000069A GT200000069A GT200000069A GT 200000069 A GT200000069 A GT 200000069A GT 200000069 A GT200000069 A GT 200000069A GT 200000069 A GT200000069 A GT 200000069A GT 200000069 A GT200000069 A GT 200000069A
- Authority
- GT
- Guatemala
- Prior art keywords
- useful
- target agents
- derivatives
- heterociclic
- amida
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Steroid Compounds (AREA)
Abstract
ESTA INVENCION SE REFIERE A DERIVADOS NOVEDOSOS DE ISOTIAZOL (VER FORMULA I, (DONDE "Z" REPRESENTA S,O, O NR; "X" ES: N O CR; "R" ES: ESTER, AMIDA, AMIDA SUSTITUIDA O SULFONAMIDAS) UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS, TALES COMO CANCERES, EN MAMIFEROS. ESTA INVENCION SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE USO DE TALES COMPUESTOS EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS EN MAMIFEROS, ESPECIALMENTE EN HUMANOS, Y A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13493399P | 1999-05-19 | 1999-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200000069A true GT200000069A (es) | 2001-11-08 |
Family
ID=22465672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200000069A GT200000069A (es) | 1999-05-19 | 2000-05-17 | Derivados heterociclicos utiles como agentes anticancerosos. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6380214B1 (es) |
EP (1) | EP1187826B1 (es) |
JP (2) | JP3692041B2 (es) |
AR (1) | AR029634A1 (es) |
AT (1) | ATE349440T1 (es) |
AU (1) | AU4137400A (es) |
BR (1) | BR0010746A (es) |
CA (1) | CA2374247C (es) |
CO (1) | CO5170417A1 (es) |
DE (1) | DE60032601T2 (es) |
DZ (1) | DZ3042A1 (es) |
ES (1) | ES2276681T3 (es) |
GT (1) | GT200000069A (es) |
HN (1) | HN2000000051A (es) |
MA (1) | MA26733A1 (es) |
MX (1) | MXPA01011920A (es) |
PA (1) | PA8494101A1 (es) |
PE (1) | PE20010152A1 (es) |
TN (1) | TNSN00104A1 (es) |
UY (1) | UY26143A1 (es) |
WO (1) | WO2000071532A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
CA2399274A1 (en) | 2000-02-07 | 2001-08-09 | Mark E. Salvati | 3-aminopyrazole inhibitors of cyclin dependent kinases |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) * | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
AP1753A (en) * | 2001-06-11 | 2007-07-18 | Shire Biochem Inc | Thiophene derivatives as antiviral agents for flavvivirus infection |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
EP1521577A1 (en) * | 2002-06-13 | 2005-04-13 | QLT, Inc. | Methods of using isothiazole derivatives to treat cancer or inflammation |
US7649012B2 (en) * | 2002-07-09 | 2010-01-19 | Fasgen, Inc. | Compounds, pharmaceutical compositions containing same, and methods of use for same |
SG149701A1 (en) * | 2002-07-09 | 2009-02-27 | Fasgen Llc | Methods of treating microbial infections in humans and animals |
BR0312798A (pt) | 2002-07-25 | 2005-05-03 | Pfizer Prod Inc | Derivados de isotiazol úteis como agentes anticancerìgenos |
JP2006510727A (ja) * | 2002-11-15 | 2006-03-30 | エクセリクシス, インク. | キナーゼモジュレーター |
KR101058696B1 (ko) * | 2002-12-10 | 2011-08-22 | 바이로켐 파마 인코포레이티드 | 후라비바이러스 감염의 치료 또는 예방을 위한 화합물과방법 |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
ES2527185T3 (es) * | 2003-03-07 | 2015-01-21 | Santen Pharmaceutical Co., Ltd | Nuevos compuestos que tienen un grupo 4-piridilalquiltio como sustituyente |
DK1636585T3 (da) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurinstoffer med kinasehæmmende aktivitet |
CL2004001834A1 (es) | 2003-07-23 | 2005-06-03 | Bayer Pharmaceuticals Corp | Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol |
JP4626353B2 (ja) * | 2004-02-17 | 2011-02-09 | 参天製薬株式会社 | 置換又は無置換アミノ基を導入した4−ピリジルアルキルチオ基を有する新規環式化合物 |
CN1918127B (zh) * | 2004-02-17 | 2012-02-15 | 参天制药株式会社 | 具有引入了取代或无取代氨基的4-吡啶基烷硫基的环状化合物 |
BRPI0507757A (pt) * | 2004-02-17 | 2007-07-10 | Santen Pharmaceutical Co Ltd | composto, composição farmacêutica, e agente terapêutico para uma doença na qual a angiogênese ou a hipermeabilidade vascular está envolvida |
AU2005223483B2 (en) | 2004-03-18 | 2009-04-23 | Zoetis Llc | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
CN101010315A (zh) | 2004-04-30 | 2007-08-01 | 拜耳制药公司 | 用于治疗癌症的取代的吡唑基脲衍生物 |
MX2007002246A (es) * | 2004-08-26 | 2007-04-20 | Pfizer Prod Inc | Procedimientos para la preparacion de derivados de isotiazol. |
JP4585978B2 (ja) * | 2005-03-03 | 2010-11-24 | 参天製薬株式会社 | キノリルアルキルチオ基を有する新規環式化合物 |
ES2415742T3 (es) | 2005-05-13 | 2013-07-26 | Vertex Pharmaceuticals (Canada) Incorporated | Compuestos y procedimientos para el tratamiento o prevención de infecciones por flavivirus |
US7932390B2 (en) | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
EA201101492A1 (ru) * | 2006-11-15 | 2012-09-28 | Вирокем Фарма Инк. | Аналоги тиофена для лечения или предупреждения флавивирусных инфекций |
WO2008105408A1 (ja) * | 2007-02-26 | 2008-09-04 | Santen Pharmaceutical Co., Ltd. | ウレイド基とアミノカルボニル基を置換基として有する新規ピロール誘導体 |
TW200911240A (en) * | 2007-06-11 | 2009-03-16 | Kyowa Hakko Kogyo Kk | Anti-tumor agent |
MX2010001636A (es) | 2007-08-14 | 2010-03-15 | Hoffmann La Roche | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
CN102625797B (zh) * | 2009-06-25 | 2014-03-26 | 江苏迈度药物研发有限公司 | 作为激酶抑制剂的取代杂环化合物及其使用方法 |
CA2867467A1 (en) | 2012-03-16 | 2013-09-19 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
SG11201705088VA (en) | 2014-12-23 | 2017-07-28 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1950990A1 (de) * | 1968-10-17 | 1970-05-14 | Ciba Geigy | Verfahren zur Herstellung von neuen triazacyclischen Verbindungen |
GB1355513A (en) * | 1971-04-07 | 1974-06-05 | May & Baker Ltd | Isothiazole derivatives |
DE2408234A1 (de) * | 1974-02-21 | 1975-09-04 | Celamerck Gmbh & Co Kg | Isothiazolylharnstoffe |
US4075001A (en) * | 1976-06-18 | 1978-02-21 | Fmc Corporation | 3-Aminoisothiazole derivatives as herbicides |
US4059433A (en) * | 1976-06-18 | 1977-11-22 | Fmc Corporation | 3-Alkoxyisothiazole derivatives as herbicides |
US4057416A (en) * | 1976-06-18 | 1977-11-08 | Fmc Corporation | 3-Alkylthio-, 3-alkylsulfinyl-, and 3-alkylsulfonylisothiazole derivatives as herbicides |
DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
DE3540377A1 (de) * | 1985-11-14 | 1987-05-21 | Bayer Ag | Thienooxazinone, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer |
DE3541631A1 (de) * | 1985-11-26 | 1987-05-27 | Bayer Ag | Selektiv-fungizide verwendung von thienylharnstoff-derivaten |
US4859699A (en) * | 1987-07-20 | 1989-08-22 | Sandoz Ltd. | Substituted N-benzoyl-N'-thienylureas |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
DE4328425A1 (de) * | 1993-08-24 | 1995-03-02 | Basf Ag | Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung |
TW276256B (es) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
CN1165482A (zh) * | 1994-11-10 | 1997-11-19 | 科西雷佩蒂斯公司 | 用作蛋白激酶抑制剂的吡唑药物组合物 |
US5792767A (en) * | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
CA2291065C (en) * | 1997-05-23 | 2010-02-09 | Bayer Corporation | Raf kinase inhibitors |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
-
2000
- 2000-04-12 HN HN2000000051A patent/HN2000000051A/es unknown
- 2000-04-17 US US09/549,893 patent/US6380214B1/en not_active Expired - Fee Related
- 2000-04-17 CO CO00028307A patent/CO5170417A1/es not_active Application Discontinuation
- 2000-04-18 PA PA20008494101A patent/PA8494101A1/es unknown
- 2000-05-03 CA CA002374247A patent/CA2374247C/en not_active Expired - Fee Related
- 2000-05-03 AT AT00920969T patent/ATE349440T1/de not_active IP Right Cessation
- 2000-05-03 EP EP00920969A patent/EP1187826B1/en not_active Expired - Lifetime
- 2000-05-03 DE DE60032601T patent/DE60032601T2/de not_active Expired - Fee Related
- 2000-05-03 AU AU41374/00A patent/AU4137400A/en not_active Abandoned
- 2000-05-03 MX MXPA01011920A patent/MXPA01011920A/es active IP Right Grant
- 2000-05-03 WO PCT/IB2000/000570 patent/WO2000071532A1/en active IP Right Grant
- 2000-05-03 ES ES00920969T patent/ES2276681T3/es not_active Expired - Lifetime
- 2000-05-03 JP JP2000619789A patent/JP3692041B2/ja not_active Expired - Lifetime
- 2000-05-03 BR BR0010746-8A patent/BR0010746A/pt not_active Application Discontinuation
- 2000-05-15 UY UY26143A patent/UY26143A1/es not_active Application Discontinuation
- 2000-05-16 PE PE2000000458A patent/PE20010152A1/es not_active Application Discontinuation
- 2000-05-17 DZ DZ000085A patent/DZ3042A1/xx active
- 2000-05-17 MA MA25977A patent/MA26733A1/fr unknown
- 2000-05-17 TN TNTNSN00104A patent/TNSN00104A1/fr unknown
- 2000-05-17 GT GT200000069A patent/GT200000069A/es unknown
- 2000-05-17 AR ARP000102369A patent/AR029634A1/es not_active Application Discontinuation
-
2004
- 2004-07-20 JP JP2004211640A patent/JP2005008641A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE60032601D1 (de) | 2007-02-08 |
AR029634A1 (es) | 2003-07-10 |
EP1187826B1 (en) | 2006-12-27 |
US6380214B1 (en) | 2002-04-30 |
CA2374247C (en) | 2008-01-22 |
JP2003500401A (ja) | 2003-01-07 |
PA8494101A1 (es) | 2003-09-05 |
WO2000071532A1 (en) | 2000-11-30 |
ES2276681T3 (es) | 2007-07-01 |
EP1187826A1 (en) | 2002-03-20 |
MA26733A1 (fr) | 2004-12-20 |
AU4137400A (en) | 2000-12-12 |
UY26143A1 (es) | 2000-12-29 |
DE60032601T2 (de) | 2007-11-15 |
JP2005008641A (ja) | 2005-01-13 |
DZ3042A1 (fr) | 2004-03-27 |
ATE349440T1 (de) | 2007-01-15 |
HN2000000051A (es) | 2001-02-02 |
CA2374247A1 (en) | 2000-11-30 |
TNSN00104A1 (fr) | 2005-11-10 |
BR0010746A (pt) | 2002-02-13 |
CO5170417A1 (es) | 2002-06-27 |
JP3692041B2 (ja) | 2005-09-07 |
PE20010152A1 (es) | 2001-02-08 |
MXPA01011920A (es) | 2002-05-06 |
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