BRPI0507757A - composto, composição farmacêutica, e agente terapêutico para uma doença na qual a angiogênese ou a hipermeabilidade vascular está envolvida - Google Patents
composto, composição farmacêutica, e agente terapêutico para uma doença na qual a angiogênese ou a hipermeabilidade vascular está envolvidaInfo
- Publication number
- BRPI0507757A BRPI0507757A BRPI0507757-5A BRPI0507757A BRPI0507757A BR PI0507757 A BRPI0507757 A BR PI0507757A BR PI0507757 A BRPI0507757 A BR PI0507757A BR PI0507757 A BRPI0507757 A BR PI0507757A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- compound
- angiogenesis
- involved
- disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
COMPOSTO, COMPOSIçãO FARMACêUTICA, E AGENTE TERAPêUTICO PARAUMA DOENçA NA QUAL A ANGIOGêNESE OU A HIPERMEABILIDADE VASCULAR ESTá ENVOLVIDA Composto cíclico possuindo grupo 4-piridilalquiltio que possui um grupo amino substituído ou não substituído nele indtroduzido ou um seu sal. Eles são úteis como um medicamento. O composto cíclico é um composto representado pela Fórmula (1) apresentada a seguir, o qual é útil para o tratamento de doenças nas quais a angiogênese participa. Na Fórmula (1) a seguir, o anel A representa um anel benzeno ou um heterociclo aromático de 5- ou 6-membros opcionalmente fundido com um anel cicloalcano; B representa alquileno; R¬ 1¬ e R¬ 2¬ cada um representa H, arila (substituída), grupo heterocíclico (substituído), etc.; R¬ 3¬ e R¬ 4¬ cada um representa H, alquila (substituída), cicloalquila (substituída), -Z-R¬ 5¬ , etc.; R¬ 5¬ representa alquila (substituída), arila (substituída), grupo heterocíclico (substituído), etc.; X e Y cada um representa H, etc.; Z representa -CO-, -COO-, -CONR¬ 6¬ , -SO~ 2~ , etc.; R¬ 6¬ representa H, etc.; p é 0, 1, ou 2; e q é 0 ou 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004039862 | 2004-02-17 | ||
JP2004294347 | 2004-09-06 | ||
PCT/JP2005/002971 WO2005085201A1 (ja) | 2004-02-17 | 2005-02-17 | 置換又は無置換アミノ基を導入した4-ピリジルアルキルチオ基を有する新規環式化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507757A true BRPI0507757A (pt) | 2007-07-10 |
Family
ID=34921640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507757-5A BRPI0507757A (pt) | 2004-02-17 | 2005-02-17 | composto, composição farmacêutica, e agente terapêutico para uma doença na qual a angiogênese ou a hipermeabilidade vascular está envolvida |
Country Status (12)
Country | Link |
---|---|
US (1) | US7544703B2 (pt) |
EP (1) | EP1717229B1 (pt) |
KR (1) | KR101179840B1 (pt) |
AT (1) | ATE512950T1 (pt) |
AU (1) | AU2005219689B2 (pt) |
BR (1) | BRPI0507757A (pt) |
CA (1) | CA2555712C (pt) |
DK (1) | DK1717229T3 (pt) |
NZ (1) | NZ548949A (pt) |
PL (1) | PL1717229T3 (pt) |
PT (1) | PT1717229E (pt) |
WO (1) | WO2005085201A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2441176T3 (es) * | 2003-03-07 | 2014-02-03 | Santen Pharmaceutical Co., Ltd. | Nuevo compuesto que tiene un grupo 4-piridilalquiltio como sustituyente |
WO2006106914A1 (ja) * | 2005-03-31 | 2006-10-12 | Santen Pharmaceutical Co., Ltd. | ピリミジニルアルキルチオ基を有する新規環式化合物 |
CN101600712A (zh) | 2007-01-29 | 2009-12-09 | 参天制药株式会社 | 具有血管新生抑制活性的新型噁二唑衍生物及噻二唑衍生物 |
AU2010271746B2 (en) * | 2009-07-17 | 2014-07-03 | Santen Pharmaceutical Co., Ltd. | 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy) phenyl]-3-pyridinecarboxamide benzene- sulfonate, crystals of same, polymorphs thereof, and processes for production thereof |
AU2014322111A1 (en) * | 2013-09-20 | 2016-04-07 | Santen Pharmaceutical Co., Ltd. | Polyethylene glycol-containing composition |
CA2979802C (en) * | 2015-03-17 | 2023-06-27 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising polypeptide |
ES2969514T3 (es) * | 2015-03-18 | 2024-05-21 | Santen Pharmaceutical Co Ltd | Composición farmacéutica de liberación sostenida |
WO2016178900A1 (en) * | 2015-05-01 | 2016-11-10 | Odin Biotech | Ocular implant for delivery of pyridinecarboxamide derivative |
AR105955A1 (es) * | 2015-09-08 | 2017-11-29 | Santen Pharmaceutical Co Ltd | Método para producir una piridinacarboxamida |
PL237497B1 (pl) * | 2018-09-17 | 2021-04-19 | Univ Medyczny Im Piastow Slaskich We Wroclawiu | Hydrazyd kwasu N’-[(antracen-9-ylo)metyleno]-2-[4,6-dimetylo- 2-sulfanylopirydyn-3-ylo-karboksamido]octowego, sposób jego otrzymywania i zastosowanie |
KR102146521B1 (ko) | 2020-01-06 | 2020-08-20 | (주)포스젯한도 | 아연도금설비의 용융아연 도금욕조용 메탈베어링 장치 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02129173A (ja) | 1988-11-10 | 1990-05-17 | Ishihara Sangyo Kaisha Ltd | トリアゾール系化合物、それらの製造方法及びそれらを含有する有害生物防除剤 |
DE3929673A1 (de) | 1989-09-07 | 1991-03-14 | Bayer Ag | Substituierte carbamoyltriazole |
JP2501051B2 (ja) | 1991-09-30 | 1996-05-29 | バンドー化学株式会社 | 搬送用ベルトの製造方法 |
SK285141B6 (sk) | 1996-02-13 | 2006-07-07 | Astrazeneca Uk Limited | Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
JP2002511852A (ja) | 1997-05-07 | 2002-04-16 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体 |
US6329372B1 (en) * | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
HN2000000051A (es) * | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
AU2002359376B2 (en) | 2001-11-08 | 2008-01-10 | Elan Pharmaceuticals, Inc. | N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
US20050113450A1 (en) | 2002-08-23 | 2005-05-26 | Atli Thorarensen | Antibacterial agents |
US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
ES2441176T3 (es) | 2003-03-07 | 2014-02-03 | Santen Pharmaceutical Co., Ltd. | Nuevo compuesto que tiene un grupo 4-piridilalquiltio como sustituyente |
-
2005
- 2005-02-17 US US10/587,410 patent/US7544703B2/en not_active Expired - Fee Related
- 2005-02-17 PL PL05710622T patent/PL1717229T3/pl unknown
- 2005-02-17 PT PT05710622T patent/PT1717229E/pt unknown
- 2005-02-17 DK DK05710622.1T patent/DK1717229T3/da active
- 2005-02-17 NZ NZ548949A patent/NZ548949A/en not_active IP Right Cessation
- 2005-02-17 KR KR1020067019034A patent/KR101179840B1/ko active IP Right Grant
- 2005-02-17 CA CA2555712A patent/CA2555712C/en not_active Expired - Fee Related
- 2005-02-17 WO PCT/JP2005/002971 patent/WO2005085201A1/ja active Application Filing
- 2005-02-17 AT AT05710622T patent/ATE512950T1/de not_active IP Right Cessation
- 2005-02-17 AU AU2005219689A patent/AU2005219689B2/en not_active Ceased
- 2005-02-17 BR BRPI0507757-5A patent/BRPI0507757A/pt not_active Application Discontinuation
- 2005-02-17 EP EP05710622A patent/EP1717229B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
AU2005219689A1 (en) | 2005-09-15 |
EP1717229A4 (en) | 2009-07-15 |
PL1717229T3 (pl) | 2011-11-30 |
NZ548949A (en) | 2009-09-25 |
US7544703B2 (en) | 2009-06-09 |
ATE512950T1 (de) | 2011-07-15 |
EP1717229B1 (en) | 2011-06-15 |
AU2005219689B2 (en) | 2011-06-09 |
CA2555712C (en) | 2013-04-23 |
KR20060135818A (ko) | 2006-12-29 |
US20070149574A1 (en) | 2007-06-28 |
EP1717229A1 (en) | 2006-11-02 |
PT1717229E (pt) | 2011-09-12 |
WO2005085201A1 (ja) | 2005-09-15 |
CA2555712A1 (en) | 2005-09-15 |
DK1717229T3 (da) | 2011-09-19 |
KR101179840B1 (ko) | 2012-09-04 |
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