EA200970510A1 - Гетеромоноциклическое соединение и его применение - Google Patents

Гетеромоноциклическое соединение и его применение

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Publication number
EA200970510A1
EA200970510A1 EA200970510A EA200970510A EA200970510A1 EA 200970510 A1 EA200970510 A1 EA 200970510A1 EA 200970510 A EA200970510 A EA 200970510A EA 200970510 A EA200970510 A EA 200970510A EA 200970510 A1 EA200970510 A1 EA 200970510A1
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EA
Eurasian Patent Office
Prior art keywords
formula
compound
group
application
diseases
Prior art date
Application number
EA200970510A
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English (en)
Inventor
Таканобу Куроита
Хироки Сакамото
Хидеюки Игава
Минору Сасаки
Коухей Асано
Цуйоси Маекава
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA200970510A1 publication Critical patent/EA200970510A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Соединение, соответствующее формуле (I)где R1 представляет собой оксогруппу, =N-R или сходные с ними;группа, соответствующая формулепредставляет собой группу, соответствующую формулеR2 представляет собой группу, соответствующую формулекаждый из R3 и R4 представляет собой Н или C-Cалкил, С-Сциклоалкил, C-Cалкокси, C-Cалкиламино, ди(C-C)алкиламино или C-Cалкилтио, каждый из которых является необязательно замещенным; и R5 представляет собой Н или C-Cалкил, С-Салкенил, циклическую группу, каждый из которых является необязательно замещенным, -CO-R8 или -O-R8', или его соль. Соединение по настоящему изобретению пригодно в качестве лекарственного средства для профилактики или лечения циркуляторных заболеваний, метаболических заболеваний и/или заболеваний центральной нервной системы.
EA200970510A 2006-11-24 2007-11-21 Гетеромоноциклическое соединение и его применение EA200970510A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006317839 2006-11-24
JP2007232106 2007-09-06
PCT/JP2007/073004 WO2008062905A2 (en) 2006-11-24 2007-11-21 Heteromonocyclic compound and use thereof

Publications (1)

Publication Number Publication Date
EA200970510A1 true EA200970510A1 (ru) 2009-12-30

Family

ID=39205144

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970510A EA200970510A1 (ru) 2006-11-24 2007-11-21 Гетеромоноциклическое соединение и его применение

Country Status (21)

Country Link
US (2) US20080207654A1 (ru)
EP (2) EP2074117A2 (ru)
JP (1) JP2010510962A (ru)
KR (1) KR20090085117A (ru)
AR (1) AR063912A1 (ru)
AU (1) AU2007322608A1 (ru)
BR (1) BRPI0719060A2 (ru)
CA (1) CA2670404A1 (ru)
CL (1) CL2007003352A1 (ru)
CO (1) CO6231035A2 (ru)
CR (1) CR10847A (ru)
EA (1) EA200970510A1 (ru)
EC (1) ECSP099461A (ru)
IL (1) IL198819A0 (ru)
MA (1) MA30985B1 (ru)
MX (1) MX2009005449A (ru)
NO (1) NO20092415L (ru)
PE (1) PE20081228A1 (ru)
TN (1) TN2009000199A1 (ru)
TW (1) TW200829581A (ru)
WO (1) WO2008062905A2 (ru)

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Also Published As

Publication number Publication date
KR20090085117A (ko) 2009-08-06
EP2074117A2 (en) 2009-07-01
WO2008062905A2 (en) 2008-05-29
IL198819A0 (en) 2010-02-17
ECSP099461A (es) 2009-11-30
CA2670404A1 (en) 2008-05-29
US20100056526A1 (en) 2010-03-04
JP2010510962A (ja) 2010-04-08
TW200829581A (en) 2008-07-16
CL2007003352A1 (es) 2008-07-04
PE20081228A1 (es) 2008-10-29
AU2007322608A1 (en) 2008-05-29
US20080207654A1 (en) 2008-08-28
WO2008062905A3 (en) 2008-12-04
CR10847A (es) 2009-07-13
MA30985B1 (fr) 2009-12-01
EP2256115A1 (en) 2010-12-01
CO6231035A2 (es) 2010-12-20
NO20092415L (no) 2009-08-17
MX2009005449A (es) 2009-06-02
AU2007322608A2 (en) 2009-07-16
TN2009000199A1 (en) 2010-10-18
AR063912A1 (es) 2009-02-25
BRPI0719060A2 (pt) 2014-02-04

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