PE20160670A1 - PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO - Google Patents
PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIOInfo
- Publication number
- PE20160670A1 PE20160670A1 PE2016000605A PE2016000605A PE20160670A1 PE 20160670 A1 PE20160670 A1 PE 20160670A1 PE 2016000605 A PE2016000605 A PE 2016000605A PE 2016000605 A PE2016000605 A PE 2016000605A PE 20160670 A1 PE20160670 A1 PE 20160670A1
- Authority
- PE
- Peru
- Prior art keywords
- pirrolo
- treat infections
- respiratory syncitial
- syncitial virus
- useful
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE TETRAHIDROFURANIL-PIRROLO[1,2-f][1,2,4]TRIAZINA-4-AMINA DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H O F; R3 ES OH O F; R4 ES CN, ALQUILO(C1-C4), ENTRE OTROS; R6 ES OH; R5 ES H, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2R,3S,4R,5S)-5-(4-AMINOPIRROLO[1,2-f][1,2,4]TRIAZIN-7-IL)-3,4-DIHIDROXI-2-(HIDROXIMETIL)TETRAHIDROFURAN-2-CARBONITRILO; (2R,3R,4R,5S)-5-(4-AMINOPIRROLO[1,2-f][1,2,4]TRIAZIN-7-IL)-2-ETINILO-4-FLUORO-2-(HIDROXIMETIL)TETRAHIDROFURAN-3-OL; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA TRATAR INFECCIONES POR EL VIRUS PNEUMOVIRINAE, QUE INCLUYE INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902544P | 2013-11-11 | 2013-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160670A1 true PE20160670A1 (es) | 2016-07-10 |
Family
ID=52003049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000605A PE20160670A1 (es) | 2013-11-11 | 2014-11-06 | PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US9388208B2 (es) |
| EP (3) | EP3068405B1 (es) |
| JP (7) | JP6234571B2 (es) |
| KR (4) | KR102113705B1 (es) |
| CN (2) | CN110003215B (es) |
| AP (1) | AP2016009186A0 (es) |
| AU (5) | AU2014346665A1 (es) |
| BR (1) | BR112016010261B1 (es) |
| CA (1) | CA2928674C (es) |
| CL (1) | CL2016001120A1 (es) |
| CR (1) | CR20160220A (es) |
| CU (1) | CU20160065A7 (es) |
| CY (1) | CY1121948T1 (es) |
| DK (2) | DK3068405T3 (es) |
| DO (1) | DOP2016000107A (es) |
| EA (2) | EA029712B1 (es) |
| ES (2) | ES2926155T3 (es) |
| GT (1) | GT201600086A (es) |
| HR (2) | HRP20220920T1 (es) |
| HU (2) | HUE059683T2 (es) |
| IL (1) | IL245324B (es) |
| LT (2) | LT3068405T (es) |
| MD (1) | MD4596C1 (es) |
| MX (2) | MX2016006066A (es) |
| MY (2) | MY182986A (es) |
| NZ (1) | NZ719592A (es) |
| PE (1) | PE20160670A1 (es) |
| PH (1) | PH12016500867A1 (es) |
| PL (2) | PL3505173T3 (es) |
| PT (2) | PT3068405T (es) |
| SG (1) | SG11201603427XA (es) |
| SI (2) | SI3068405T1 (es) |
| TR (1) | TR201910961T4 (es) |
| UA (1) | UA119050C2 (es) |
| WO (1) | WO2015069939A1 (es) |
| ZA (1) | ZA201603123B (es) |
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| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
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