BR112015014737A2 - compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico - Google Patents

compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico

Info

Publication number
BR112015014737A2
BR112015014737A2 BR112015014737A BR112015014737A BR112015014737A2 BR 112015014737 A2 BR112015014737 A2 BR 112015014737A2 BR 112015014737 A BR112015014737 A BR 112015014737A BR 112015014737 A BR112015014737 A BR 112015014737A BR 112015014737 A2 BR112015014737 A2 BR 112015014737A2
Authority
BR
Brazil
Prior art keywords
activity
antibiotic
spiroisoxazoline
compound
enhancing
Prior art date
Application number
BR112015014737A
Other languages
English (en)
Inventor
Baulard Alain
Deprez Benoît
Agouridas-Dudot Laurence
Frédérik Desroses Matthieu
Willand Nicolas
Brodin Priscille
Original Assignee
Univ De Droit Et De La Sante De Lille 2
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ De Droit Et De La Sante De Lille 2 filed Critical Univ De Droit Et De La Sante De Lille 2
Publication of BR112015014737A2 publication Critical patent/BR112015014737A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

resumo patente de invenção: "compostos spiroisoxazolina tendo uma atividade de potencialização de atividade de um antibiótico". a presente invenção refere-se a composto spiroisoxazolina de fórmula genérica (i): onde m e n são 0 ou 1, r1 representa, inter alia, uma cadeia alquila opcionalmente substituída, em particular substituída por flúor ou com um grupo cíclico, e r2 é escolhido de fenila e benzila opcionalmente substituído, ciclopropila, ciclobutila, ciclopentila, ciclo-hexila, e os heterociclos tendo 5 ou 6 vértices compreendendo pelo menos um átomo escolhido de s, n e o. a presente invenção também refere-se ao uso deste composto como uma fármaco, em particular no tratamento de infecções bacterianas e micobacterianas tal como tuberculose em combinação com um antibiótico que é ativo contra bactérias e/ou micobactérias, o dito composto potencializando a atividade do dito antibiótico.
BR112015014737A 2012-12-21 2013-12-20 compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico BR112015014737A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1203549A FR3000064A1 (fr) 2012-12-21 2012-12-21 Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
PCT/EP2013/077706 WO2014096369A1 (fr) 2012-12-21 2013-12-20 Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique

Publications (1)

Publication Number Publication Date
BR112015014737A2 true BR112015014737A2 (pt) 2017-07-11

Family

ID=48521020

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014737A BR112015014737A2 (pt) 2012-12-21 2013-12-20 compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico

Country Status (14)

Country Link
US (1) US10174050B2 (pt)
EP (1) EP2935281B1 (pt)
JP (1) JP6487333B2 (pt)
KR (1) KR20150138153A (pt)
CN (1) CN104936964B (pt)
AU (1) AU2013366494B2 (pt)
BR (1) BR112015014737A2 (pt)
CA (1) CA2895590A1 (pt)
EA (1) EA201590876A1 (pt)
FR (1) FR3000064A1 (pt)
HK (1) HK1215251A1 (pt)
IL (1) IL239554A0 (pt)
WO (1) WO2014096369A1 (pt)
ZA (1) ZA201503956B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN104945416B (zh) * 2014-03-24 2017-11-17 中国科学院上海药物研究所 一类螺异噁唑啉衍生物、其制备方法及医药用途
JP2020531577A (ja) * 2017-08-16 2020-11-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 新規化合物
CN110997680B (zh) 2017-08-16 2022-10-21 葛兰素史密斯克莱知识产权发展有限公司 新型化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11512723A (ja) * 1995-09-29 1999-11-02 イーライ リリー アンド カンパニー フィブリノゲン依存血小板凝集抑制物質としてのスピロ化合物
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
DE102005044813A1 (de) * 2005-05-19 2007-10-04 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
US7964624B1 (en) * 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
FR2903405B1 (fr) 2006-07-04 2011-09-09 Pasteur Institut Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
WO2009080432A2 (en) 2007-12-21 2009-07-02 Eth Zurich Composition for treatment of tuberculosis
US20110059948A1 (en) * 2008-01-14 2011-03-10 Jyoti Chattopadhyaya Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as anti-mycobacterial agents
EP2445495A1 (en) * 2009-06-25 2012-05-02 Bioversys AG Composition for treatment of tuberculosis
US8583638B2 (en) * 2009-08-27 2013-11-12 Apple Inc. Adaptive mapping of search results
WO2011146324A1 (en) 2010-05-18 2011-11-24 Merck Sharp & Dohme Corp. Spiro isoxazoline compounds as sstr5 antagonists
EP2771338A2 (en) 2011-10-25 2014-09-03 Université de Droit et de la Santé de Lille 2 1, 2, 4 - oxadiazole derivatives as ethr inhibitors for use in the treatment tuberculosis
FR3000491B1 (fr) * 2012-09-27 2015-08-28 Univ Lille Ii Droit & Sante Composes utilisables dans le traitement des infections mycobacteriennes
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes

Also Published As

Publication number Publication date
FR3000064A1 (fr) 2014-06-27
IL239554A0 (en) 2015-08-31
JP6487333B2 (ja) 2019-03-20
US10174050B2 (en) 2019-01-08
CN104936964A (zh) 2015-09-23
AU2013366494A1 (en) 2015-07-09
EA201590876A1 (ru) 2016-05-31
EP2935281B1 (fr) 2020-09-09
CN104936964B (zh) 2017-11-03
KR20150138153A (ko) 2015-12-09
EP2935281A1 (fr) 2015-10-28
ZA201503956B (en) 2016-04-28
HK1215251A1 (zh) 2016-08-19
JP2016503777A (ja) 2016-02-08
WO2014096369A1 (fr) 2014-06-26
US20150344498A1 (en) 2015-12-03
CA2895590A1 (en) 2014-06-26
AU2013366494B2 (en) 2018-04-19

Similar Documents

Publication Publication Date Title
NZ751197A (en) Compounds and methods of treating infections
PE20160670A1 (es) PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO
BR112014017749A8 (pt) Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo
BR112015026644A2 (pt) composto de tetrazolinona e uso do mesmo
EA201201648A1 (ru) Стимуляторы sgc
UY38428A (es) Nuevos compuestos antihelmínticos
GEP20156309B (en) Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EA201390198A1 (ru) Гетероциклическое соединение
BR112015014279A2 (pt) heterociclos nitrogenados saturados e n-acilados potencializando a atividade de um antibiótico ativo contra as micobactérias
NZ607580A (en) N-heteroaryl compounds
UA109290C2 (uk) Спільні кристали і солі інгібіторів ccr3
UY32131A (es) Compuestos de anillo fusionado y uso de los mismos
BR112013017520A2 (pt) composto bicíclico ou sal do mesmo
BR112015014737A2 (pt) compostos spiroisoxazolina tendo uma atividade potencializando a atividade de um antibiótico
BR112012019565A2 (pt) formulações antimicrobianas com base em polissacarídeo
BR112019024549A2 (pt) compostos derivados de glicopeptídeo e usos dos mesmos
BR112017015744A2 (pt) composto apresentando uma estrutura de fórmula (i), um sal farmaceuticamente aceitável do mesmo ou um isômero ótico do mesmo, composição farmacêutica e uso do composto de fórmula (i) para o tratamento e prevenção de mycobacterium tuberculosis ou outras infecções microbianas
MX2018016339A (es) Compuestos heterociclicos antiinfecciosos y sus usos.
BR112015006243A2 (pt) agentes antibacterianos de fenicol
TR201910158T4 (tr) İmmün hastalıklara yönelik önleyici ve/veya terapötik ajan.
WO2013060744A3 (en) 1, 2, 4 - oxadiazole derivatives as ethr inhibitors for use in the treatment tuberculosis
EA202090750A1 (ru) Производные глюконовой кислоты для применения в лечении и/или предупреждении инфекций, вызываемых микроорганизмами
BR112017008101A2 (pt) composto, composição farmacêutica, métodos para inibir o dnae bacteriano e para tratar uma infecção, e, uso de um composto.
CO2020001506A2 (es) Nuevos compuestos
GEP20186874B (en) Hydrochloride salts of an antibiotic compound

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2545 DE 15-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.