FR2903405B1 - Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications - Google Patents

Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications

Info

Publication number
FR2903405B1
FR2903405B1 FR0606088A FR0606088A FR2903405B1 FR 2903405 B1 FR2903405 B1 FR 2903405B1 FR 0606088 A FR0606088 A FR 0606088A FR 0606088 A FR0606088 A FR 0606088A FR 2903405 B1 FR2903405 B1 FR 2903405B1
Authority
FR
France
Prior art keywords
compounds
applications
potentiating effect
ethionamide
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0606088A
Other languages
English (en)
Other versions
FR2903405A1 (fr
Inventor
Benoit Deprez
Nicolas Willand
Bertrand Dirie
Patrick Toto
Vincent Villeret
Camille Locht
Alain Baulard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Lille 2 Droit et Sante
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Lille 2 Droit et Sante
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0606088A priority Critical patent/FR2903405B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Lille 2 Droit et Sante, Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP07803843A priority patent/EP2044064A1/fr
Priority to AU2007271013A priority patent/AU2007271013A1/en
Priority to CNA2007800326714A priority patent/CN101516876A/zh
Priority to AP2009004747A priority patent/AP2009004747A0/xx
Priority to KR1020097002316A priority patent/KR20090043506A/ko
Priority to US12/306,333 priority patent/US8338599B2/en
Priority to CA2656502A priority patent/CA2656502C/fr
Priority to BRPI0714225-0A priority patent/BRPI0714225A2/pt
Priority to EA200970081A priority patent/EA200970081A1/ru
Priority to JP2009517335A priority patent/JP2009541474A/ja
Priority to PCT/FR2007/001138 priority patent/WO2008003861A1/fr
Publication of FR2903405A1 publication Critical patent/FR2903405A1/fr
Priority to ZA200810703A priority patent/ZA200810703B/xx
Application granted granted Critical
Publication of FR2903405B1 publication Critical patent/FR2903405B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0606088A 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications Expired - Fee Related FR2903405B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR0606088A FR2903405B1 (fr) 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
JP2009517335A JP2009541474A (ja) 2006-07-04 2007-07-04 エチオナミド活性の増強効果を有する化合物及びその使用
CNA2007800326714A CN101516876A (zh) 2006-07-04 2007-07-04 具有乙硫异烟胺活性增强作用的化合物及其用途
AP2009004747A AP2009004747A0 (en) 2006-07-04 2007-07-04 Compounds having a potentiating effect on the activity of ethoionamide and uses thereof
KR1020097002316A KR20090043506A (ko) 2006-07-04 2007-07-04 에티온아미드 활성 강화 효과를 갖는 화합물 및 그 용도
US12/306,333 US8338599B2 (en) 2006-07-04 2007-07-04 Compounds having a potentiating effect on the activity of ethionamide and uses thereof
EP07803843A EP2044064A1 (fr) 2006-07-04 2007-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
BRPI0714225-0A BRPI0714225A2 (pt) 2006-07-04 2007-07-04 compostos de efeito potencializador da atividade da etionamida e as respectivas aplicaÇÕes
EA200970081A EA200970081A1 (ru) 2006-07-04 2007-07-04 Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения
AU2007271013A AU2007271013A1 (en) 2006-07-04 2007-07-04 Compounds having a potentiating effect on the activity of ethionamide and uses thereof
PCT/FR2007/001138 WO2008003861A1 (fr) 2006-07-04 2007-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
CA2656502A CA2656502C (fr) 2006-07-04 2007-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
ZA200810703A ZA200810703B (en) 2006-07-04 2008-12-19 Compounds having a potentiating effect on the activity of ethionamide and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0606088A FR2903405B1 (fr) 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications

Publications (2)

Publication Number Publication Date
FR2903405A1 FR2903405A1 (fr) 2008-01-11
FR2903405B1 true FR2903405B1 (fr) 2011-09-09

Family

ID=37775154

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0606088A Expired - Fee Related FR2903405B1 (fr) 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications

Country Status (13)

Country Link
US (1) US8338599B2 (fr)
EP (1) EP2044064A1 (fr)
JP (1) JP2009541474A (fr)
KR (1) KR20090043506A (fr)
CN (1) CN101516876A (fr)
AP (1) AP2009004747A0 (fr)
AU (1) AU2007271013A1 (fr)
BR (1) BRPI0714225A2 (fr)
CA (1) CA2656502C (fr)
EA (1) EA200970081A1 (fr)
FR (1) FR2903405B1 (fr)
WO (1) WO2008003861A1 (fr)
ZA (1) ZA200810703B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2234643B1 (fr) 2007-12-21 2013-01-09 ETH Zurich Composition pour le traitement de la tuberculose
GB0813740D0 (en) * 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
CN102458393B (zh) 2009-06-25 2014-08-20 生物验证系统股份公司 治疗肺结核的组合物
GB0916608D0 (en) * 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2012040170A2 (fr) * 2010-09-20 2012-03-29 University Of Virginia Patent Foundation Compositions et méthodes de traitement de la tuberculose
WO2013060744A2 (fr) 2011-10-25 2013-05-02 Universite De Droit Et De La Sante De Lille 2 Composés présentant une activité d'inhibition d'ethr, utilisation desdits composés en tant que médicaments, composition pharmaceutique et produit contenant lesdits composés
ES2632237T3 (es) 2012-02-02 2017-09-12 Idorsia Pharmaceuticals Ltd Compuestos de 4-(benzoimidazol-2-il)-tiazol y derivados aza relacionados
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
FR3000064A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
TR201807959T4 (tr) 2013-07-22 2018-06-21 Idorsia Pharmaceuticals Ltd 1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
ES2709985T3 (es) 2015-01-15 2019-04-22 Idorsia Pharmaceuticals Ltd Derivados de hidroxialquil-piperazina como moduladores del receptor CXCR3
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
KR102657861B1 (ko) * 2017-08-16 2024-04-17 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 신규 화합물
BR112020004356A2 (pt) * 2017-09-08 2020-12-01 Pi Industries Ltd. novos compostos heterocíclicos fungicidas
CN108558858A (zh) * 2018-05-23 2018-09-21 成都师范学院 硝基呋喃类抗结核化合物
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
JP2023538199A (ja) * 2020-06-23 2023-09-07 ナンキン イムノファージ バイオテック カンパニー リミテッド 化合物およびｍｉｆ阻害剤としての用途

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Publication number Priority date Publication date Assignee Title
FR2275458A1 (fr) * 1974-06-21 1976-01-16 Aries Robert Analogues de la rifampicine portant un noyau oxadiazole
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2001002375A1 (fr) * 1999-07-01 2001-01-11 Chemrx Advanced Technologies, Inc. Synthese d'oxadiazoles
US20010049373A1 (en) * 2000-01-28 2001-12-06 Chalquest Richard R. Materials and methods for killing nematodes and nematode eggs
JP4901102B2 (ja) * 2002-05-03 2012-03-21 エクセリクシス， インク． プロテインキナーゼモジュレーターおよびその使用方法
US7074809B2 (en) * 2002-08-09 2006-07-11 Astrazeneca Ab Compounds
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
CN1898235A (zh) * 2003-12-24 2007-01-17 普罗西迪恩有限公司 作为gpcr受体激动剂的杂环衍生物
EP1604989A1 (fr) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft Inhibiteurs de DPP-IV
AU2005290081B2 (en) * 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
TW200633990A (en) * 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
WO2006060424A2 (fr) * 2004-12-01 2006-06-08 Kalypsys, Inc. Inhibiteurs de la dimerisation de l'oxyde nitrique synthase inductible
AU2005316826A1 (en) * 2004-12-15 2006-06-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1838706A1 (fr) * 2004-12-24 2007-10-03 Prosidion Limited Agonistes du récepteur couplé aux protéines g

Also Published As

Publication number Publication date
WO2008003861A1 (fr) 2008-01-10
AU2007271013A1 (en) 2008-01-10
EP2044064A1 (fr) 2009-04-08
US20110136823A1 (en) 2011-06-09
AP2009004747A0 (en) 2009-02-28
CA2656502A1 (fr) 2008-01-10
FR2903405A1 (fr) 2008-01-11
EA200970081A1 (ru) 2009-06-30
JP2009541474A (ja) 2009-11-26
CN101516876A (zh) 2009-08-26
US8338599B2 (en) 2012-12-25
BRPI0714225A2 (pt) 2013-01-29
CA2656502C (fr) 2017-06-13
ZA200810703B (en) 2009-10-28
KR20090043506A (ko) 2009-05-06

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