ZA200810703B - Compounds having a potentiating effect on the activity of ethionamide and uses thereof - Google Patents

Compounds having a potentiating effect on the activity of ethionamide and uses thereof

Info

Publication number
ZA200810703B
ZA200810703B ZA200810703A ZA200810703A ZA200810703B ZA 200810703 B ZA200810703 B ZA 200810703B ZA 200810703 A ZA200810703 A ZA 200810703A ZA 200810703 A ZA200810703 A ZA 200810703A ZA 200810703 B ZA200810703 B ZA 200810703B
Authority
ZA
South Africa
Prior art keywords
ethionamide
activity
compounds
potentiating effect
potentiating
Prior art date
Application number
ZA200810703A
Other languages
English (en)
Inventor
Benoit Deprez
Nicolas Willand
Bertrand Dirie
Patrick Toto
Vincent Villeret
Camille Locht
Alain Baulard
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Univ Lille 2
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient, Univ Lille 2, Inst Nat Sante Rech Med filed Critical Pasteur Institut
Publication of ZA200810703B publication Critical patent/ZA200810703B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200810703A 2006-07-04 2008-12-19 Compounds having a potentiating effect on the activity of ethionamide and uses thereof ZA200810703B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0606088A FR2903405B1 (fr) 2006-07-04 2006-07-04 Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications

Publications (1)

Publication Number Publication Date
ZA200810703B true ZA200810703B (en) 2009-10-28

Family

ID=37775154

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200810703A ZA200810703B (en) 2006-07-04 2008-12-19 Compounds having a potentiating effect on the activity of ethionamide and uses thereof

Country Status (13)

Country Link
US (1) US8338599B2 (fr)
EP (1) EP2044064A1 (fr)
JP (1) JP2009541474A (fr)
KR (1) KR20090043506A (fr)
CN (1) CN101516876A (fr)
AP (1) AP2009004747A0 (fr)
AU (1) AU2007271013A1 (fr)
BR (1) BRPI0714225A2 (fr)
CA (1) CA2656502C (fr)
EA (1) EA200970081A1 (fr)
FR (1) FR2903405B1 (fr)
WO (1) WO2008003861A1 (fr)
ZA (1) ZA200810703B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009080432A2 (fr) 2007-12-21 2009-07-02 Eth Zurich Composition destinée au traitement de la tuberculose
GB0813740D0 (en) * 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
WO2010149761A1 (fr) 2009-06-25 2010-12-29 Bioversys Gmbh Composition pour le traitement de la tuberculose
GB0916608D0 (en) * 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
US9333193B2 (en) * 2010-09-20 2016-05-10 University Of Virginia Patent Foundation Compositions and methods for treating tuberculosis
EP2771338A2 (fr) 2011-10-25 2014-09-03 Université de Droit et de la Santé de Lille 2 Derives de 1,2,4-oxadiazoles comme inhibiteurs d'ethr pour l'utilisation dans le traitement de la tuberculose
UA113638C2 (xx) 2012-02-02 2017-02-27 4-(бензоімідазол-2-іл)-тіазольні сполуки та споріднені азапохідні
FR3000064A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CA2916338C (fr) 2013-07-22 2021-07-06 Actelion Pharmaceuticals Ltd Derives de 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
TR201900680T4 (tr) 2015-01-15 2019-02-21 Idorsia Pharmaceuticals Ltd CXCR3 Reseptör modülatörleri olarak hidroksialkil- piperazin türevleri.
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
DK3668853T3 (da) * 2017-08-16 2021-12-06 Glaxosmithkline Ip Dev Ltd Nye forbindelser
CN111655687A (zh) * 2017-09-08 2020-09-11 Pi工业有限公司 新型杀真菌杂环化合物
CN108558858A (zh) * 2018-05-23 2018-09-21 成都师范学院 硝基呋喃类抗结核化合物
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
KR20230026487A (ko) * 2020-06-23 2023-02-24 난징 이뮤노파지 바이오테크 코., 엘티디. 화합물 및 mif 억제제로서의 용도

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2275458A1 (fr) * 1974-06-21 1976-01-16 Aries Robert Analogues de la rifampicine portant un noyau oxadiazole
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU5891600A (en) * 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
US20020002171A1 (en) * 2000-01-28 2002-01-03 Chalquest Richard R. Materials and methods for killing nematodes and nematode eggs
CA2484209C (fr) * 2002-05-03 2013-06-11 Exelixis, Inc. Modulateurs de proteine kinase et procedes d'utilisation
AU2003264018A1 (en) * 2002-08-09 2004-02-25 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
WO2005061489A1 (fr) * 2003-12-24 2005-07-07 Prosidion Limited Derives heterocycliques utilises comme agonistes des recepteurs gpcr
EP1604989A1 (fr) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft Inhibiteurs de DPP-IV
US7544677B2 (en) * 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
TW200633990A (en) * 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
WO2006060424A2 (fr) * 2004-12-01 2006-06-08 Kalypsys, Inc. Inhibiteurs de la dimerisation de l'oxyde nitrique synthase inductible
CA2589084A1 (fr) * 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibiteurs d'activite akt
US8193359B2 (en) * 2004-12-24 2012-06-05 Prosidion Limited G-protein coupled receptor agonists

Also Published As

Publication number Publication date
CA2656502C (fr) 2017-06-13
WO2008003861A1 (fr) 2008-01-10
AU2007271013A1 (en) 2008-01-10
KR20090043506A (ko) 2009-05-06
EA200970081A1 (ru) 2009-06-30
JP2009541474A (ja) 2009-11-26
US8338599B2 (en) 2012-12-25
US20110136823A1 (en) 2011-06-09
BRPI0714225A2 (pt) 2013-01-29
AP2009004747A0 (en) 2009-02-28
EP2044064A1 (fr) 2009-04-08
CA2656502A1 (fr) 2008-01-10
FR2903405B1 (fr) 2011-09-09
FR2903405A1 (fr) 2008-01-11
CN101516876A (zh) 2009-08-26

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