AR099789A1 - Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina - Google Patents
Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolinaInfo
- Publication number
- AR099789A1 AR099789A1 ARP150100819A ARP150100819A AR099789A1 AR 099789 A1 AR099789 A1 AR 099789A1 AR P150100819 A ARP150100819 A AR P150100819A AR P150100819 A ARP150100819 A AR P150100819A AR 099789 A1 AR099789 A1 AR 099789A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- phenyl
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Reivindicación 1: Un compuesto de fórmula (1) donde R¹ representa heteroaril-alquilo C₁₋₂, donde el heteroarilo es un anillo aromático monocíclico o bicíclico de 5 a 10 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre oxígeno, nitrógeno y azufre, y donde el heteroarilo está sin sustituir o sustituido una o dos veces con alquilo C₁₋₄; o heterociclil-alquilo C₁₋₂ donde el heterociclilo es un anillo no aromático monocíclico de 5 ó 6 miembros que contiene uno o dos átomos de nitrógeno que está anillado a un anillo de fenilo o piridinilo, y donde el heterociclilo está sin sustituir o sustituido una o dos veces donde los sustituyentes son independientemente seleccionados del grupo que consiste en alquilo C₁₋₄ y oxo; R² representa hidrógeno o metilo; R³ representa arilo, donde el arilo es un grupo fenilo o naftilo, grupos los cuales están independientemente sin sustituir o sustituidos una o dos veces donde los sustituyentes son independientemente seleccionados del grupo que consiste en halógeno, alquilo C₁₋₄, alcoxi C₁₋₄, fluoroalquilo C₁₋₂, fluoroalcoxi C₁₋₂ y ciano; aril-alquilo C₁₋₂, donde el arilo es un grupo fenilo o naftilo, dichos grupos están independientemente no sustituidos o sustituidos una vez con halógeno; heteroarilo, donde el heteroarilo es un anillo aromático monocíclico o bicíclico de 5 a 10 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre oxígeno, nitrógeno y azufre, y donde el heteroarilo está sin sustituir o sustituido una o dos veces donde los sustituyentes son independientemente seleccionados del grupo que consiste en halógeno, alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, fluoroalquilo C₁₋₂, fluoroalcoxi C₁₋₂, di-alquil C₁₋₂-amino, hidroxi, ciano, fenilo, piridinilo y heteroaril-alquilo C₁₋₂, donde el heteroarilo es un anillo aromático monocíclico de 5 ó 6 miembros que contiene 1 ó 2 heteroátomos seleccionados independientemente entre oxígeno, nitrógeno y azufre; aril-alquil C₁₋₂-sulfonilo, donde el arilo es un grupo fenilo o naftilo; o R⁶-carbonilo; R⁴ representa hidrógeno, halógeno, fluoroalquilo C₁₋₂ o ciano; R⁵ representa hidrógeno, halógeno o fluoroalquilo C₁₋₂; y R⁶ representa alquilo C₁₋₄; cicloalquilo C₃₋₆, donde el cicloalquilo está sin sustituir o sustituido una vez con fenilo; cicloalquilo C₅₋₆, donde el cicloalquilo está anillado a un anillo de fenilo; alcoxi C₁₋₂-alquilo C₁₋₂; arilo, donde el arilo es un grupo fenilo o naftilo, grupos los cuales están independientemente sin sustituir o sustituidos una o dos veces donde los sustituyentes son independientemente seleccionados del grupo que consiste en halógeno, alquilo C₁₋₄, alcoxi C₁₋₄, fluoroalquilo C₁₋₂ y di-alquil C₁₋₂-amino; aril-alquilo C₁₋₂, donde el arilo es un grupo fenilo o naftilo, grupos los cuales están independientemente sin sustituir o sustituidos una o dos veces donde los sustituyentes son independientemente seleccionados del grupo que consiste en halógeno y alcoxi C₁₋₄; ariloxi-alquilo C₁₋₂, donde el arilo es un grupo fenilo o naftilo; aril-alcoxi C₁₋₂, donde el arilo es un grupo fenilo o naftilo; heterociclil-alquilo C₁₋₂, donde el heterociclilo es un anillo no aromático monocíclico de 5 ó 6 miembros que contiene uno o dos heteroátomos seleccionados independientemente entre oxígeno y nitrógeno; heteroarilo, donde el heteroarilo es un anillo aromático monocíclico o bicíclico de 5 a 10 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre oxígeno, nitrógeno y azufre, y donde el heteroarilo está sin sustituir o sustituido una vez con alquilo C₁₋₄; o heteroaril-alquilo C₁₋₂, donde el heteroarilo es un anillo aromático monocíclico o bicíclico de 5 a 10 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre oxígeno, nitrógeno y azufre; o su sal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2014060092 | 2014-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099789A1 true AR099789A1 (es) | 2016-08-17 |
Family
ID=52815062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100819A AR099789A1 (es) | 2014-03-24 | 2015-03-18 | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
Country Status (14)
Country | Link |
---|---|
US (1) | US9951063B2 (es) |
EP (1) | EP3122741B1 (es) |
JP (1) | JP6424234B2 (es) |
KR (1) | KR102356410B1 (es) |
CN (1) | CN106103426B (es) |
AR (1) | AR099789A1 (es) |
AU (1) | AU2015237826A1 (es) |
BR (1) | BR112016022046A8 (es) |
CA (1) | CA2939893C (es) |
ES (1) | ES2682398T3 (es) |
MX (1) | MX2016012451A (es) |
RU (1) | RU2016141443A (es) |
TW (1) | TW201623280A (es) |
WO (1) | WO2015145322A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2014295123B2 (en) | 2013-07-22 | 2018-08-02 | Idorsia Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
CN107250133B (zh) * | 2015-01-15 | 2020-09-15 | 爱杜西亚药品有限公司 | 作为cxcr3受体调节剂的羟烷基哌嗪衍生物 |
US11046670B2 (en) | 2015-10-19 | 2021-06-29 | Board Of Regents, The University Of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
WO2017190109A1 (en) * | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
WO2018011265A1 (en) | 2016-07-13 | 2018-01-18 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
WO2018083136A1 (en) * | 2016-11-03 | 2018-05-11 | F. Hoffmann-La Roche Ag | Novel tetrahydroisoquinolines and terahydronaphthyridines for the treatment and prophylaxis of hepatitis b virus infection |
CN108794456B (zh) * | 2018-04-28 | 2020-07-14 | 北京施安泰医药技术开发有限公司 | 一类抗乙肝药物、其制备方法、药物组合物及其用途 |
CN115843298B (zh) | 2020-07-22 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型 |
KR102281647B1 (ko) * | 2020-12-09 | 2021-07-30 | 메디케어제약 주식회사 | 피페라진-퀴놀린 유도체의 제조방법 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60031285T2 (de) * | 1999-08-27 | 2007-08-30 | Chemocentryx Inc., Mountain View | Heterozyclische verbindungen und verfahren zur modulierung von cxcr3 funktion |
CA2432985A1 (en) | 2001-01-23 | 2002-08-01 | Vincent Mancuso | Piperazine- and piperidine-derivatives as melanocortin receptor agonists |
EP1368339A1 (en) | 2001-01-23 | 2003-12-10 | Eli Lilly & Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
EP1363631A4 (en) | 2001-03-02 | 2005-11-16 | Bristol Myers Squibb Co | "COMPOUNDS SUITED AS MODULATORS OF MELANOCORTIN RECEPTORS AND THESE PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF" |
US20050256130A1 (en) | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
WO2003105853A1 (en) | 2002-06-12 | 2003-12-24 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
WO2005035534A1 (ja) | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 |
US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
US20050119252A1 (en) | 2003-10-22 | 2005-06-02 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
CN1882347A (zh) | 2003-11-21 | 2006-12-20 | 阿雷生物药品公司 | Akt蛋白激酶抑制剂 |
US20060276465A1 (en) | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
CN101189238A (zh) | 2005-02-16 | 2008-05-28 | 先灵公司 | 具有cxcr3拮抗剂活性的哌嗪-哌啶 |
MX2007009948A (es) | 2005-02-16 | 2007-09-26 | Schering Corp | Pierazin-piperidinas sustituidas con piridilo y fenilo conectados por aminos con actividad antagonista de cxcr3. |
US7868005B2 (en) | 2005-02-16 | 2011-01-11 | Schering Corporation | Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity |
KR20070107075A (ko) | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Cxcr3 길항제 활성을 갖는 신규의 헤테로사이클릭치환된 피리딘 또는 페닐 화합물 |
CA2598456A1 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Heterocyclic substituted piperazines with cxcr3 antagonist activity |
KR20070107040A (ko) | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Cxcr3 길항제 활성을 갖는 헤테로아릴-치환된피라지닐-피페라진-피페리딘 |
CN101213185A (zh) | 2005-02-16 | 2008-07-02 | 先灵公司 | 具有cxcr3拮抗活性的吡啶基和苯基取代的哌嗪-哌啶 |
WO2007002742A1 (en) | 2005-06-28 | 2007-01-04 | Pharmacopeia, Inc. | Substituted [1,4]-diazepanes as cxcr3 antagonists and their use in the treatment of inflammatory disorders |
US7754724B2 (en) | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
ES2382163T3 (es) | 2005-10-11 | 2012-06-05 | Schering Corporation | Compuestos heterocíclicos sustituidos con actividad antagonista de CXCR3 |
EP1957076A2 (en) | 2005-11-29 | 2008-08-20 | Merck & Co., Inc. | Thiazole derivatives as cxcr3 receptor modulators |
WO2007070433A2 (en) | 2005-12-12 | 2007-06-21 | Merck & Co., Inc. | 2-arylthiazole derivatives as cxcr3 receptor modulators |
WO2007076318A2 (en) | 2005-12-21 | 2007-07-05 | Smithkline Beecham Corporation | Camphor-derived cxcr3 antagonists |
EP1988900A2 (en) * | 2006-02-23 | 2008-11-12 | Merck & Co., Inc. | Pyridine, pyrimidine and pyrazine derivatives as cxcr3 receptor modulators |
WO2007109238A1 (en) | 2006-03-21 | 2007-09-27 | Schering Corporation | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
FR2903405B1 (fr) | 2006-07-04 | 2011-09-09 | Pasteur Institut | Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications |
KR20090043512A (ko) | 2006-07-14 | 2009-05-06 | 쉐링 코포레이션 | Cxcr3 길항제 활성을 갖는 헤테로사이클릭 치환된 피페라진 화합물 |
WO2008013622A2 (en) | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
JP2010513520A (ja) | 2006-12-22 | 2010-04-30 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する複素環式化合物 |
WO2008091594A2 (en) | 2007-01-24 | 2008-07-31 | E. I. Du Pont De Nemours And Company | Fungicidal mixtures |
JP5337711B2 (ja) | 2007-01-25 | 2013-11-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺菌性アミド |
EP2185154A2 (en) | 2007-08-03 | 2010-05-19 | Schering Corporation | Method of treating cxcr3 mediated diseases using heterocyclic substituted piperazines |
TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
WO2009079490A1 (en) | 2007-12-18 | 2009-06-25 | Schering Corporation | Process and intermediates for the synthesis of heterocyclic substituted piperazines with cxcr3 antagonist activity |
KR20150065958A (ko) | 2008-01-25 | 2015-06-15 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 살균제 복소환 화합물 |
KR20100105890A (ko) | 2008-01-25 | 2010-09-30 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 살균제 아미드 |
PE20091576A1 (es) | 2008-02-19 | 2009-11-05 | Sanofi Aventis | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
KR20100135952A (ko) | 2008-04-30 | 2010-12-27 | 바이엘 크롭사이언스 아게 | 식물 보호제로서의 티아졸-4-카복실산 에스테르 및 티오에스테르 |
JP5785495B2 (ja) | 2008-10-01 | 2015-09-30 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 植物保護剤としてのヘテロシクリル置換チアゾール類 |
KR101052065B1 (ko) | 2008-10-15 | 2011-07-27 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법 |
TW201036966A (en) | 2008-12-02 | 2010-10-16 | Du Pont | Fungicidal heterocyclic compounds |
JP2012511525A (ja) | 2008-12-11 | 2012-05-24 | バイエル・クロップサイエンス・アーゲー | 植物保護剤としてのチアゾリルオキシムエーテルおよびヒドラゾン |
US8362249B2 (en) | 2009-04-27 | 2013-01-29 | Boehringer Ingelheim International Gmbh | CXCR3 receptor antagonists |
WO2010126811A1 (en) * | 2009-04-27 | 2010-11-04 | Boehringer Ingelheim International Gmbh | Cxcr3 receptor antagonists |
EP2272846A1 (de) | 2009-06-23 | 2011-01-12 | Bayer CropScience AG | Thiazolylpiperidin Derivate als Fungizide |
AU2010283832A1 (en) | 2009-08-12 | 2012-02-23 | Syngenta Participations Ag | Microbiocidal heterocycles |
UA107938C2 (en) | 2009-08-12 | 2015-03-10 | Syngenta Participations Ag | Heterocycles with microbicidal properties |
WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
JP5827626B2 (ja) | 2009-10-30 | 2015-12-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | ヘテロアリールピペリジン及びピペラジン誘導体 |
CN102781937B (zh) | 2009-12-21 | 2015-09-30 | 拜尔农作物科学股份公司 | 用作杀菌剂的双(二氟甲基)吡唑 |
US8952004B2 (en) | 2010-01-07 | 2015-02-10 | Boehringer Ingelheim International Gmbh | CXCR3 receptor antagonists |
ES2613066T3 (es) | 2010-04-28 | 2017-05-22 | Bayer Intellectual Property Gmbh | Derivados de cetoheteroarilpiperidina y -piperazina como fungicidas |
US8815775B2 (en) | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
EP2571866A1 (en) | 2010-05-20 | 2013-03-27 | E.I. Du Pont De Nemours And Company | Fungicidal oximes and hydrazones |
BR112012030184A2 (pt) | 2010-05-27 | 2015-12-29 | Bayer Cropscience Ag | derivados de ácido piridinilcarboxílico como fungicidas |
US20120122928A1 (en) | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
US8759527B2 (en) | 2010-08-25 | 2014-06-24 | Bayer Cropscience Ag | Heteroarylpiperidine and -piperazine derivatives as fungicides |
KR101797074B1 (ko) | 2010-10-27 | 2017-11-13 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체 |
EP2643312B1 (en) | 2010-11-25 | 2014-09-10 | Syngenta Participations AG | Microbicidal heterocycles |
MX2013006936A (es) | 2010-12-17 | 2013-07-22 | Du Pont | Ambas azociclicas fungicidas. |
KR101848116B1 (ko) | 2011-02-01 | 2018-04-11 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체 |
WO2012107475A1 (en) | 2011-02-10 | 2012-08-16 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
AR085333A1 (es) | 2011-02-10 | 2013-09-25 | Syngenta Participations Ag | Derivados de pirazol microbicidas |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
WO2013037768A1 (de) | 2011-09-15 | 2013-03-21 | Bayer Intellectual Property Gmbh | Piperidinpyrazole als fungizide |
WO2013056915A1 (en) | 2011-10-18 | 2013-04-25 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
WO2013056911A1 (en) | 2011-10-18 | 2013-04-25 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
EP2794563B1 (en) | 2011-12-21 | 2017-02-22 | Actelion Pharmaceuticals Ltd | Heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
BR112014018714A8 (pt) | 2012-02-02 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Compostos de 4-(benzoimidazol-2-il)-tiazol e derivados de aza relacionados |
DE102012203270A1 (de) | 2012-03-01 | 2013-09-05 | Bundesdruckerei Gmbh | Dokument und Verfahren zum Herstellen des Dokuments |
EP2820015A1 (en) | 2012-03-02 | 2015-01-07 | Syngenta Participations AG | Microbiocidal pyrazole derivatives |
WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
WO2014075873A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
WO2014075874A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
ES2695350T3 (es) | 2012-12-11 | 2019-01-03 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
TWI632142B (zh) | 2013-06-24 | 2018-08-11 | 德商拜耳作物科學股份有限公司 | 作為殺真菌劑之六氫吡啶羧酸衍生物 |
AU2014295123B2 (en) | 2013-07-22 | 2018-08-02 | Idorsia Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
CN107250133B (zh) | 2015-01-15 | 2020-09-15 | 爱杜西亚药品有限公司 | 作为cxcr3受体调节剂的羟烷基哌嗪衍生物 |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
-
2015
- 2015-03-18 AR ARP150100819A patent/AR099789A1/es unknown
- 2015-03-23 JP JP2016558779A patent/JP6424234B2/ja active Active
- 2015-03-23 ES ES15714957.6T patent/ES2682398T3/es active Active
- 2015-03-23 EP EP15714957.6A patent/EP3122741B1/en active Active
- 2015-03-23 MX MX2016012451A patent/MX2016012451A/es unknown
- 2015-03-23 CA CA2939893A patent/CA2939893C/en active Active
- 2015-03-23 WO PCT/IB2015/052098 patent/WO2015145322A1/en active Application Filing
- 2015-03-23 RU RU2016141443A patent/RU2016141443A/ru unknown
- 2015-03-23 US US15/128,846 patent/US9951063B2/en active Active
- 2015-03-23 BR BR112016022046A patent/BR112016022046A8/pt not_active Application Discontinuation
- 2015-03-23 CN CN201580014469.3A patent/CN106103426B/zh active Active
- 2015-03-23 AU AU2015237826A patent/AU2015237826A1/en not_active Abandoned
- 2015-03-23 TW TW104109242A patent/TW201623280A/zh unknown
- 2015-03-23 KR KR1020167029233A patent/KR102356410B1/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
TW201623280A (zh) | 2016-07-01 |
JP2017508773A (ja) | 2017-03-30 |
ES2682398T3 (es) | 2018-09-20 |
CA2939893C (en) | 2022-07-19 |
WO2015145322A1 (en) | 2015-10-01 |
JP6424234B2 (ja) | 2018-11-14 |
CA2939893A1 (en) | 2015-10-01 |
KR102356410B1 (ko) | 2022-01-26 |
EP3122741B1 (en) | 2018-06-06 |
BR112016022046A8 (pt) | 2017-12-26 |
RU2016141443A (ru) | 2018-04-25 |
CN106103426B (zh) | 2019-03-19 |
US9951063B2 (en) | 2018-04-24 |
US20170107214A1 (en) | 2017-04-20 |
CN106103426A (zh) | 2016-11-09 |
KR20160135798A (ko) | 2016-11-28 |
EP3122741A1 (en) | 2017-02-01 |
MX2016012451A (es) | 2017-01-06 |
AU2015237826A1 (en) | 2016-11-03 |
BR112016022046A2 (pt) | 2017-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR099789A1 (es) | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina | |
AR110405A1 (es) | Compuestos | |
AR100645A1 (es) | Derivados de pirazolo-pirimidina | |
AR106605A1 (es) | Oxadiazoles sustituidos para combatir hongos fitopatógenos | |
AR104884A1 (es) | Compuestos de 4-hidroxi-3-(heteroaril)piridin-2-ona como agonistas de apj | |
AR099995A1 (es) | Piridilamidinas fungicidas | |
AR102177A1 (es) | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos | |
AR094299A1 (es) | Derivados de ftalazin-1(2h)-ona sustituidos | |
AR093921A1 (es) | Derivados de indol carboxamida como antagonistas del receptor p2x7 | |
AR095311A1 (es) | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante | |
AR097279A1 (es) | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx | |
AR104025A1 (es) | Carbamatos de piperazina como moduladores de magl y/o abhd6, procesos para su preparación y composiciones farmacéuticas | |
AR094812A1 (es) | Derivado de piridina monocíclico como inhibidor del fgfr | |
AR100809A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
AR100712A1 (es) | Compuestos de pirazol como bloqueadores de los canales de calcio tipo t | |
AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
AR091519A1 (es) | Inhibidores pirrolopirazona de tanquirasa | |
AR095359A1 (es) | Compuestos heteroaromáticos y su uso como ligandos d1 de dopamina | |
AR103414A1 (es) | Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 | |
AR102079A1 (es) | DERIVADOS BICÍCLICOS QUE TIENEN ACTIVIDAD COMO AGONISTAS ADRENÉRGICOS b2 Y COMO ANTAGONISTAS MUSCARÍNICOS M3 | |
AR103742A1 (es) | Derivados de trifluorometilpropanamida | |
AR109296A1 (es) | Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) | |
AR109711A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
AR100439A1 (es) | Derivados de carboxamida | |
AR097252A1 (es) | Derivado de pirazolilpirazol sustituido y el uso del mismo como herbicida |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |