AR100712A1 - Compuestos de pirazol como bloqueadores de los canales de calcio tipo t - Google Patents
Compuestos de pirazol como bloqueadores de los canales de calcio tipo tInfo
- Publication number
- AR100712A1 AR100712A1 ARP150101743A ARP150101743A AR100712A1 AR 100712 A1 AR100712 A1 AR 100712A1 AR P150101743 A ARP150101743 A AR P150101743A AR P150101743 A ARP150101743 A AR P150101743A AR 100712 A1 AR100712 A1 AR 100712A1
- Authority
- AR
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- Prior art keywords
- alkyl
- cycloalkyl
- fluoroalkyl
- cyano
- alkoxy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Estos compuestos son útiles como bloqueadores de los canales de calcio tipo T. Reivindicación 1: Un compuesto de fórmula (1) en donde X representa un átomo de carbono anular o de nitrógeno anular; R¹ representa alquilo C₂₋₆; alquilo C₂₋₄ monosustituido con ciano o alcoxi C₁₋₃; fluoroalquilo C₁₋₄; fluoroalcoxi C₁₋₃; pentafluoro-sulfanilo; cicloalquilo C₃₋₆-L¹- en donde dicho cicloalquilo C₃₋₆ opcionalmente contiene un átomo de oxígeno anular; en donde dicho cicloalquilo C₃₋₆ no está sustituido o está monosustituido con flúor, alquilo C₁₋₃, alcoxi C₁₋₃, hidroxi, ciano o fluoroalquilo C₁₋₃ o disustituido con flúor o trisustituido con dos sustituyentes flúor y un sustituyente seleccionado entre alquilo C₁₋₃ y ciano; y el conector L¹ representa un enlace directo, alquileno C₁₋₂, oxígeno o alquilen C₁₋₂-oxi; heteroarilo de 5 ó 6 miembros, de manera independiente opcionalmente monosustituido con alquilo C₁₋₃; -NR¹¹R¹², en donde R¹¹ y R¹² independientemente representan hidrógeno, alquilo C₁₋₃, fluoroalquilo C₂₋₃, cicloalquilo C₃₋₆, cicloalquilo C₃₋₆ monosustituido o disustituido con flúor, cicloalquil C₃₋₆-alquilo C₁₋₃, alcoxi C₁₋₃-alquilo C₂₋₃; o R¹¹ y R¹², junto con el átomo de nitrógeno al cual están unidos, forman un anillo de 4 a 6 miembros opcionalmente monosustituido o disustituido con flúor; un grupo 2-oxo-pirrolidinilo o un grupo morfolinilo; y (R⁴)ₙ representa uno o dos sustituyentes opcionales independientemente seleccionados entre alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, fluoroalquilo C₁₋₃, fluoroalcoxi C₁₋₃, halógeno y ciano; o R¹ junto con (R⁴)ₙ forman un anillo no aromático de 5 ó 6 miembros que está fusionado al anillo fenilo / piridina; en donde dicho anillo de 5 ó 6 miembros opcionalmente contiene uno o dos heteroátomos seleccionados independientemente entre oxígeno y nitrógeno; en donde dicho anillo no aromático de 5 ó 6 miembros fusionado está, de manera independiente, a su vez opcionalmente monosustituido con oxo o alquilo C₁₋₃; disustituido con alquilo C₁₋₃; o di-, tri- o tetra-sustituido en donde un sustituyente es oxo y los demás son alquilo C₁₋₃; o R¹ junto con (R⁴)ₙ forman un anillo aromático de 5 ó 6 miembros que está fusionado al anillo fenilo / piridina; en donde dicho anillo de 5 ó 6 miembros opcionalmente contiene uno o dos heteroátomos seleccionados de nitrógeno, en donde dicho anillo aromático de 5 ó 6 miembros fusionado está, de manera independiente, a su vez opcionalmente monosustituido o disustituido en donde los sustituyentes se seleccionan de manera independiente entre alquilo C₁₋₃, cicloalquilo C₃₋₆, fluoroalquilo C₁ o ciano; o R¹ representa metilo o halógeno; y (R⁴)ₙ representa un sustituyente seleccionado de fluoroalcoxi C₁₋₃ que está unido al anillo fenilo / piridinilo en la posición orto o meta por el punto de unión del grupo -CH₂-CO-NH-; Y representa un átomo de carbono anular o de nitrógeno anular; y R² representa alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, cicloalquil C₃₋₆-oxi, fluoroalquilo C₁₋₃, fluoroalcoxi C₁₋₃, alcoxi C₁₋₃-alcoxi C₂₋₃, halógeno, ciano, o -NR²¹R²², en donde R²¹ y R²² independientemente representan hidrógeno o alquilo C₁₋₃, o R²¹ y R²², junto con el átomo de nitrógeno al cual están unidos, forman un anillo de 4 a 6 miembros opcionalmente monosustituido o disustituido con flúor o un grupo morfolinilo; y (R⁵)ₘ representa uno o dos sustituyentes opcionales independientemente seleccionados entre alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, halógeno, ciano, fluoroalquilo C₁₋₃ y fluoroalcoxi C₁₋₃; o una sal de dicho compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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IB2014061901 | 2014-06-03 |
Publications (1)
Publication Number | Publication Date |
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AR100712A1 true AR100712A1 (es) | 2016-10-26 |
Family
ID=53385705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP150101743A AR100712A1 (es) | 2014-06-03 | 2015-06-02 | Compuestos de pirazol como bloqueadores de los canales de calcio tipo t |
Country Status (33)
Country | Link |
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US (2) | US9932314B2 (es) |
EP (1) | EP3152199B1 (es) |
JP (1) | JP6195684B2 (es) |
KR (1) | KR101906031B1 (es) |
CN (1) | CN106414429B (es) |
AR (1) | AR100712A1 (es) |
AU (1) | AU2015270118C1 (es) |
CA (1) | CA2947002C (es) |
CL (1) | CL2016003092A1 (es) |
CY (1) | CY1120864T1 (es) |
DK (1) | DK3152199T3 (es) |
EA (1) | EA031104B1 (es) |
ES (1) | ES2696351T3 (es) |
HR (1) | HRP20181670T1 (es) |
HU (1) | HUE040489T2 (es) |
IL (1) | IL249275B (es) |
LT (1) | LT3152199T (es) |
MA (1) | MA40281B1 (es) |
MX (1) | MX2016015923A (es) |
NZ (1) | NZ727818A (es) |
PE (1) | PE20170129A1 (es) |
PH (1) | PH12016502230A1 (es) |
PL (1) | PL3152199T3 (es) |
PT (1) | PT3152199T (es) |
RS (1) | RS57943B1 (es) |
SG (1) | SG11201609974PA (es) |
SI (1) | SI3152199T1 (es) |
TN (1) | TN2016000542A1 (es) |
TR (1) | TR201816624T4 (es) |
TW (2) | TWI675827B (es) |
UA (1) | UA121548C2 (es) |
WO (1) | WO2015186056A1 (es) |
ZA (1) | ZA201608821B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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SI3152199T1 (sl) | 2014-06-03 | 2018-12-31 | Idorsia Pharmaceuticals Ltd | Pirazolne spojine in njihova uporaba kot blokatorji kalcijevega kanala tipa T |
US10246426B2 (en) | 2014-09-15 | 2019-04-02 | Idorsia Pharmaceuticals Ltd | Triazole compounds as T-type calcium channel blockers |
KR102486298B1 (ko) * | 2016-02-09 | 2023-01-06 | 인벤티스바이오 엘엘씨 | 인돌아민-2,3-디옥시게나아제(ido)의 억제제 |
US11046683B2 (en) | 2016-12-15 | 2021-06-29 | Ono Pharmaceutical Co., Ltd. | Activator of TREK (TWIK RElated K+ channels) channels |
KR102296653B1 (ko) * | 2016-12-16 | 2021-09-01 | 이도르시아 파마슈티컬스 리미티드 | T-유형 칼슘 채널 차단제를 포함하는 약학 조합물 |
US20210128537A1 (en) * | 2016-12-21 | 2021-05-06 | Praxis Precision Medicines, Inc. | T-type calcium channel modulators and methods of use thereof |
TWI808960B (zh) * | 2017-02-06 | 2023-07-21 | 瑞士商愛杜西亞製藥有限公司 | 用於合成1-芳基-1-三氟甲基環丙烷之新穎方法 |
AU2018296423B2 (en) * | 2017-07-05 | 2022-07-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of N-[1-(5-cyano-pyridin-2-ylmethyl)-1 H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
US11795148B2 (en) | 2017-12-12 | 2023-10-24 | Queen's University At Kingston | Compounds and methods for inhibiting CYP26 enzymes |
EP3997068A1 (en) | 2019-07-11 | 2022-05-18 | Cura Therapeutics, LLC | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
JP2022540253A (ja) | 2019-07-11 | 2022-09-14 | プラクシス プレシジョン メディシンズ, インコーポレイテッド | T型カルシウムチャネル調節因子の製剤およびその使用方法 |
EP4076405A1 (en) | 2019-12-20 | 2022-10-26 | Idorsia Pharmaceuticals Ltd | Pharmaceutical compositions comprising n-[1-(5-cyano-pyridin-2-ylmethyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
WO2023277658A1 (ko) * | 2021-07-02 | 2023-01-05 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제 합성을 위한 중간체의 제조 방법 |
WO2023240205A1 (en) | 2022-06-10 | 2023-12-14 | Neurocrine Biosciences, Inc. | Deuterated compounds |
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