AR096984A1 - Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona - Google Patents

Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona

Info

Publication number
AR096984A1
AR096984A1 ARP140102686A ARP140102686A AR096984A1 AR 096984 A1 AR096984 A1 AR 096984A1 AR P140102686 A ARP140102686 A AR P140102686A AR P140102686 A ARP140102686 A AR P140102686A AR 096984 A1 AR096984 A1 AR 096984A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
mono
alkoxy
heterocyclyl
Prior art date
Application number
ARP140102686A
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English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51225512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR096984(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR096984A1 publication Critical patent/AR096984A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1) donde: X representa N o CH; Y representa N o CR⁶; R¹ representa alquilo C₁₋₄; cicloalquilo C₃₋₆; alcoxi C₁₋₄; cicloalcoxi C₃₋₆; fluoroalquilo C₁₋₃; fluoroalcoxi C₁₋₃; halógeno; ciano; alcoxi C₁₋₂-alcoxi C₂₋₃; alquilo C₁₋₃ que está mono-sustituido con -NR⁷R⁸; alcoxi C₂₋₃ que está mono-sustituido con -NR⁷R⁸; heterociclilo, donde el heterociclilo es un anillo saturado mono-cíclico de 4 a 6 miembros que contiene uno o dos heteroátomos independientemente seleccionados entre nitrógeno y oxígeno y donde dicho heterociclilo no está sustituido o mono-sustituido con alquilo C₁₋₂; o heterocicliloxi, donde el heterociclilo es un anillo saturado mono-cíclico de 4 a 6 miembros que contiene un átomo de oxígeno; R² representa hidrógeno, alcoxi C₁₋₄ o flúor; R³ representa hidrógeno o alquilo C₁₋₄; R⁴ representa alquilo C₁₋₄, alquilo C₁₋₄ que está mono-sustituido con hidroxi, o alquilo C₁₋₂ que está mono-sustituido con -NR⁷R⁸; R⁵ representa alquilo C₁₋₄ o alquilo C₁₋₄ que está mono-sustituido con hidroxi; R⁶ representa hidrógeno, alquilo C₁₋₄ o flúor; o R¹ y R⁶ forman, junto con los átomos de carbono a los cuales están unidos, un anillo heterocíclico de 5 ó 6 miembros, donde el resto necesario para completar dicho anillo heterocíclico se selecciona entre -OCH₂CH₂-*, -OCH₂O-*, -OCH₂CH₂CH₂-* y -OCH₂CH₂O-*, donde los asteriscos indican el enlace que está ligado al átomo de carbono que lleva R⁶; R⁷ representa alquilo C₁₋₂; y R⁸ representa alquilo C₁₋₂; o una sal del mismo.
ARP140102686A 2013-07-22 2014-07-21 Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona AR096984A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2013056001 2013-07-22

Publications (1)

Publication Number Publication Date
AR096984A1 true AR096984A1 (es) 2016-02-10

Family

ID=51225512

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140102686A AR096984A1 (es) 2013-07-22 2014-07-21 Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona

Country Status (22)

Country Link
US (1) US10259807B2 (es)
EP (1) EP3024832B1 (es)
JP (1) JP6330040B2 (es)
KR (1) KR102295416B1 (es)
CN (1) CN105658649B (es)
AR (1) AR096984A1 (es)
AU (1) AU2014295123B2 (es)
BR (1) BR112016001238B1 (es)
CA (1) CA2916338C (es)
CL (1) CL2016000152A1 (es)
EA (1) EA030067B1 (es)
ES (1) ES2671323T3 (es)
IL (1) IL243650A0 (es)
MA (1) MA38857B1 (es)
MX (1) MX363432B (es)
PH (1) PH12016500134B1 (es)
PL (1) PL3024832T3 (es)
SA (1) SA516370398B1 (es)
SG (1) SG11201600504TA (es)
TR (1) TR201807959T4 (es)
TW (1) TWI630205B (es)
WO (1) WO2015011099A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3024832B1 (en) 2013-07-22 2018-03-28 Idorsia Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
JP6337218B2 (ja) 2015-01-15 2018-06-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｃｘｃｒ３受容体調節剤としてのヒドロキシアルキル−ピペラジン誘導体
WO2018011265A1 (en) 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators

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