PE20091576A1 - DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 - Google Patents
DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3Info
- Publication number
- PE20091576A1 PE20091576A1 PE2009000232A PE2009000232A PE20091576A1 PE 20091576 A1 PE20091576 A1 PE 20091576A1 PE 2009000232 A PE2009000232 A PE 2009000232A PE 2009000232 A PE2009000232 A PE 2009000232A PE 20091576 A1 PE20091576 A1 PE 20091576A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- benzamide
- substituted
- azinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
REFERIDA A UN DERIVADO DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA DE FORMULA (I), DONDE Q, Q1 E Y SON CO O SO2; X ES HALOGENO; R1 ES ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FENILO O HALOGENO; R2, R4 Y R6 SON H, ALQUILO C1-C12 OPCIONALMENTE SUSTITUIDO CON FENILO O HALOGENO; R3 ES UN GRUPO AROMATICO TAL COMO ARILO DE 6 A 14 ATOMOS DE CARBONO O HETEROARILO DE 5 A 14 MIEMBROS; A ES CH, N, ENTRE OTROS; R5 ES JGZ, R8R7NQ1-ALQUILO C1-C4, AZAHETEROCICLILO DE 3 A 7 MIEMBROS, ENTRE OTROS; J ES ALCOXICARBONILO C1-C4, ALQUILTIO C1-C4, ENTRE OTROS; G ES ALQUILO C1-C4, CICLOALQUILO C3-C7, HETEROCICLILO DE 3 A 7 MIEMBROS; Z ES UN ENLACE, CO O SO2; R7 Y R8 SON H O ALQUILO C1-C4; R9 Y R10 SON H, ALQUILO C1-C4, ENTRE OTROS; m ES UN ENTERO DE 1 A 3; n Y p SON 0 O UN ENTERO DE 1 A 5. SON COMPUESTOS PREFERIDOS: N-{5-[2-(4-CLORO-FENIL)-ETILCARBAMOIL]-2-[4-(2-DIMETILAMINO-ETIL)-PIPERAZIN-1-IL]-FENIL}-ISONICOTINAMIDA, N-{5-[2-(3-CLORO-FENIL)-ETILCARBAMOIL]-2-[4-(2-DIMETILAMINO-ETIL)-PIPERAZIN-1-IL]-FENIL}-ISONICOTINAMIDA, 3-(3-CLORO-BENZOILAMINO)-N-[2-(2,4-DICLORO-FENIL)-ETIL]-4-[4-(3-PIRROLIDIN-1-IL-PROPIONIL)-PIPERAZIN-1-IL]-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 Y SON UTILES EN EL TRATAMIENTO DE ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, ASMA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2973808P | 2008-02-19 | 2008-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091576A1 true PE20091576A1 (es) | 2009-11-05 |
Family
ID=40527535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000232A PE20091576A1 (es) | 2008-02-19 | 2009-02-17 | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8268828B2 (es) |
| EP (1) | EP2262784B1 (es) |
| JP (1) | JP2011512412A (es) |
| KR (1) | KR20100123835A (es) |
| CN (1) | CN102007108A (es) |
| AR (1) | AR070430A1 (es) |
| AU (1) | AU2009215643A1 (es) |
| BR (1) | BRPI0908815A2 (es) |
| CA (1) | CA2715557A1 (es) |
| CL (1) | CL2009000368A1 (es) |
| CO (1) | CO6241113A2 (es) |
| CR (1) | CR11604A (es) |
| DO (1) | DOP2010000254A (es) |
| EC (1) | ECSP10010409A (es) |
| IL (1) | IL207597A0 (es) |
| MA (1) | MA32191B1 (es) |
| MX (1) | MX2010008397A (es) |
| NI (1) | NI201000132A (es) |
| NZ (1) | NZ587380A (es) |
| PE (1) | PE20091576A1 (es) |
| RU (1) | RU2010138577A (es) |
| SV (1) | SV2010003648A (es) |
| TW (1) | TW200948791A (es) |
| WO (1) | WO2009105435A1 (es) |
| ZA (1) | ZA201005314B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091576A1 (es) | 2008-02-19 | 2009-11-05 | Sanofi Aventis | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
| WO2010126811A1 (en) | 2009-04-27 | 2010-11-04 | Boehringer Ingelheim International Gmbh | Cxcr3 receptor antagonists |
| WO2011084985A1 (en) * | 2010-01-07 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Cxcr3 receptor antagonists |
| KR101251788B1 (ko) | 2010-12-06 | 2013-04-08 | 기아자동차주식회사 | 차량 연비 정보 단말표시 시스템 및 그 방법 |
| ES2649995T3 (es) | 2011-07-18 | 2018-01-16 | Merck Patent Gmbh | Benzamidas |
| EP2601950A1 (en) | 2011-12-06 | 2013-06-12 | Sanofi | Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists |
| ES2738600T3 (es) * | 2012-01-10 | 2020-01-24 | Merck Patent Gmbh | Derivados de benzamida como moduladores de la hormona folículo estimulante |
| MX352181B (es) | 2012-02-02 | 2017-11-13 | Idorsia Pharmaceuticals Ltd | Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados. |
| EP2666769A1 (en) | 2012-05-23 | 2013-11-27 | Sanofi | Substituted B-amino acid derivatives as CXCR3 receptor antagonist |
| AR096984A1 (es) | 2013-07-22 | 2016-02-10 | Actelion Pharmaceuticals Ltd | Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| SG10201901192TA (en) * | 2014-09-10 | 2019-03-28 | Epizyme Inc | Smyd inhibitors |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| US10053457B2 (en) | 2015-01-15 | 2018-08-21 | Idorsia Pharmaceuticals Ltd. | Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators |
| DK3600312T3 (da) * | 2017-03-26 | 2023-07-31 | Takeda Pharmaceuticals Co | Piperidinyl- og piperazinylsubstituerede heteroaromatiske carboxamider som modulatorer af gpr6 |
| CN116410159B (zh) * | 2023-06-09 | 2023-08-22 | 济南国鼎医药科技有限公司 | 一种恩曲替尼中间体的制备方法及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2052541A5 (es) * | 1969-06-13 | 1971-04-09 | Takeda Chemical Industries Ltd | |
| US3840556A (en) * | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US6124319A (en) | 1997-01-21 | 2000-09-26 | Merck & Co., Inc. | 3,3-disubstituted piperidines as modulators of chemokine receptor activity |
| US6469002B1 (en) | 2001-04-19 | 2002-10-22 | Millennium Pharmaceuticals, Inc. | Imidazolidine compounds |
| US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
| GB0203994D0 (en) | 2002-02-20 | 2002-04-03 | Celltech R&D Ltd | Chemical compounds |
| EP1554253A4 (en) | 2002-06-03 | 2006-09-20 | Smithkline Beecham Corp | IMIDAZOLIUM COMPOUNDS INHIBITORS OF CXCR3 |
| US6734659B1 (en) | 2002-06-13 | 2004-05-11 | Mykrolis Corporation | Electronic interface for use with dual electrode capacitance diaphragm gauges |
| CN101146793A (zh) * | 2005-02-16 | 2008-03-19 | 先灵公司 | 具有cxcr3拮抗剂活性的新的杂环取代了的吡啶或苯基化合物 |
| CN101142209A (zh) | 2005-02-16 | 2008-03-12 | 先灵公司 | 具有cxcr3拮抗剂活性的吡嗪基取代的哌嗪-哌啶 |
| US7776862B2 (en) * | 2005-02-16 | 2010-08-17 | Schering Corporation | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity |
| US20080312215A1 (en) | 2005-06-28 | 2008-12-18 | Pharmacopeia Drug Discovery, Inc. | Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders |
| WO2007047202A1 (en) | 2005-10-11 | 2007-04-26 | Schering Corporation | Substituted heterocyclic compounds with cxcr3 antagonist activity |
| US20090143413A1 (en) | 2005-11-29 | 2009-06-04 | Adams Alan D | Thiazole Derivatives as CXCR3 Receptor Modulators |
| CN101460482B (zh) | 2006-03-21 | 2013-03-27 | 默沙东公司 | 具有cxcr3拮抗剂活性的杂环取代的吡啶化合物 |
| AU2007272884A1 (en) | 2006-07-14 | 2008-01-17 | Pharmacopeia, Inc. | Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity |
| PE20091576A1 (es) | 2008-02-19 | 2009-11-05 | Sanofi Aventis | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
-
2009
- 2009-02-17 PE PE2009000232A patent/PE20091576A1/es not_active Application Discontinuation
- 2009-02-18 KR KR1020107018467A patent/KR20100123835A/ko not_active Application Discontinuation
- 2009-02-18 CN CN2009801138321A patent/CN102007108A/zh active Pending
- 2009-02-18 AU AU2009215643A patent/AU2009215643A1/en not_active Abandoned
- 2009-02-18 AR ARP090100561A patent/AR070430A1/es not_active Application Discontinuation
- 2009-02-18 JP JP2010547712A patent/JP2011512412A/ja active Pending
- 2009-02-18 BR BRPI0908815A patent/BRPI0908815A2/pt not_active IP Right Cessation
- 2009-02-18 WO PCT/US2009/034340 patent/WO2009105435A1/en active Application Filing
- 2009-02-18 CA CA2715557A patent/CA2715557A1/en not_active Abandoned
- 2009-02-18 RU RU2010138577/04A patent/RU2010138577A/ru not_active Application Discontinuation
- 2009-02-18 MX MX2010008397A patent/MX2010008397A/es not_active Application Discontinuation
- 2009-02-18 CL CL2009000368A patent/CL2009000368A1/es unknown
- 2009-02-18 EP EP09711984.6A patent/EP2262784B1/en active Active
- 2009-02-18 NZ NZ587380A patent/NZ587380A/en not_active IP Right Cessation
- 2009-02-19 TW TW098105199A patent/TW200948791A/zh unknown
-
2010
- 2010-07-26 ZA ZA2010/05314A patent/ZA201005314B/en unknown
- 2010-07-28 CR CR11604A patent/CR11604A/es not_active Application Discontinuation
- 2010-07-29 NI NI201000132A patent/NI201000132A/es unknown
- 2010-08-06 US US12/852,076 patent/US8268828B2/en active Active
- 2010-08-12 IL IL207597A patent/IL207597A0/en unknown
- 2010-08-18 EC EC2010010409A patent/ECSP10010409A/es unknown
- 2010-08-18 DO DO2010000254A patent/DOP2010000254A/es unknown
- 2010-08-18 SV SV2010003648A patent/SV2010003648A/es not_active Application Discontinuation
- 2010-08-19 CO CO10102315A patent/CO6241113A2/es not_active Application Discontinuation
- 2010-09-13 MA MA33173A patent/MA32191B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2262784A1 (en) | 2010-12-22 |
| US8268828B2 (en) | 2012-09-18 |
| NI201000132A (es) | 2011-03-16 |
| JP2011512412A (ja) | 2011-04-21 |
| RU2010138577A (ru) | 2012-03-27 |
| BRPI0908815A2 (pt) | 2019-09-24 |
| IL207597A0 (en) | 2010-12-30 |
| US20100305088A1 (en) | 2010-12-02 |
| TW200948791A (en) | 2009-12-01 |
| CL2009000368A1 (es) | 2009-06-26 |
| DOP2010000254A (es) | 2010-08-31 |
| ECSP10010409A (es) | 2010-09-30 |
| CA2715557A1 (en) | 2009-08-27 |
| MX2010008397A (es) | 2010-08-23 |
| KR20100123835A (ko) | 2010-11-25 |
| AR070430A1 (es) | 2010-04-07 |
| MA32191B1 (fr) | 2011-04-01 |
| NZ587380A (en) | 2011-09-30 |
| CO6241113A2 (es) | 2011-01-20 |
| EP2262784B1 (en) | 2014-04-16 |
| AU2009215643A1 (en) | 2009-08-27 |
| CN102007108A (zh) | 2011-04-06 |
| WO2009105435A1 (en) | 2009-08-27 |
| ZA201005314B (en) | 2011-03-30 |
| SV2010003648A (es) | 2011-01-31 |
| CR11604A (es) | 2010-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |