MX352181B - Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados. - Google Patents
Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados.Info
- Publication number
- MX352181B MX352181B MX2014009355A MX2014009355A MX352181B MX 352181 B MX352181 B MX 352181B MX 2014009355 A MX2014009355 A MX 2014009355A MX 2014009355 A MX2014009355 A MX 2014009355A MX 352181 B MX352181 B MX 352181B
- Authority
- MX
- Mexico
- Prior art keywords
- benzoimidazol
- thiazole compounds
- aza derivatives
- related aza
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La invención se relaciona con compuestos de la Fórmula (I) (ver Fórmula) donde el anillo A, X, (R1)n, R2, R3, R4, R4', R5 n, y p son como se describió en la memoria descriptiva; a una sal farmacéuticamente aceptable de los mismos, y al uso de tales compuestos como medicamentos, especialmente como moduladores del receptor CXCR3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB2012/050489 | 2012-02-02 | ||
PCT/IB2013/050870 WO2013114332A1 (en) | 2012-02-02 | 2013-02-01 | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009355A MX2014009355A (es) | 2014-09-01 |
MX352181B true MX352181B (es) | 2017-11-13 |
Family
ID=48014121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009355A MX352181B (es) | 2012-02-02 | 2013-02-01 | Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados. |
Country Status (21)
Country | Link |
---|---|
US (1) | US9266876B2 (es) |
EP (1) | EP2809668B1 (es) |
JP (1) | JP6073931B2 (es) |
KR (1) | KR101800607B1 (es) |
CN (1) | CN104093715B (es) |
AU (1) | AU2013216354B2 (es) |
BR (1) | BR112014018714A8 (es) |
CA (1) | CA2861020C (es) |
CL (1) | CL2014002048A1 (es) |
EA (1) | EA027595B1 (es) |
ES (1) | ES2632237T3 (es) |
HK (1) | HK1203939A1 (es) |
IL (1) | IL233872A (es) |
MX (1) | MX352181B (es) |
MY (1) | MY170524A (es) |
NZ (1) | NZ629795A (es) |
PH (1) | PH12014501540A1 (es) |
PL (1) | PL2809668T3 (es) |
SG (1) | SG11201404144PA (es) |
UA (1) | UA113638C2 (es) |
WO (1) | WO2013114332A1 (es) |
Families Citing this family (10)
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AU2014295123B2 (en) * | 2013-07-22 | 2018-08-02 | Idorsia Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
JP6510539B2 (ja) | 2014-01-09 | 2019-05-08 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ, ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ. デヴィッド グラッドストーン | 置換ベンゾオキサジン及び関連化合物 |
AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
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GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
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EP4228632A2 (en) * | 2020-10-16 | 2023-08-23 | Saint Louis University | Rev-erb agonists |
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KR101797074B1 (ko) | 2010-10-27 | 2017-11-13 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체 |
EP2643312B1 (en) | 2010-11-25 | 2014-09-10 | Syngenta Participations AG | Microbicidal heterocycles |
MX2013006936A (es) | 2010-12-17 | 2013-07-22 | Du Pont | Ambas azociclicas fungicidas. |
KR101848116B1 (ko) | 2011-02-01 | 2018-04-11 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체 |
AR085333A1 (es) | 2011-02-10 | 2013-09-25 | Syngenta Participations Ag | Derivados de pirazol microbicidas |
WO2012107475A1 (en) | 2011-02-10 | 2012-08-16 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
WO2013037768A1 (de) | 2011-09-15 | 2013-03-21 | Bayer Intellectual Property Gmbh | Piperidinpyrazole als fungizide |
WO2013056911A1 (en) | 2011-10-18 | 2013-04-25 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
WO2013056915A1 (en) | 2011-10-18 | 2013-04-25 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
EP2820012A1 (en) | 2012-03-02 | 2015-01-07 | Syngenta Participations AG | Microbiocidal pyrazole derivatives |
EP2820015A1 (en) | 2012-03-02 | 2015-01-07 | Syngenta Participations AG | Microbiocidal pyrazole derivatives |
WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
WO2014075873A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
WO2014075874A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
-
2013
- 2013-02-01 BR BR112014018714A patent/BR112014018714A8/pt not_active IP Right Cessation
- 2013-02-01 NZ NZ629795A patent/NZ629795A/en not_active IP Right Cessation
- 2013-02-01 CN CN201380007926.7A patent/CN104093715B/zh active Active
- 2013-02-01 AU AU2013216354A patent/AU2013216354B2/en not_active Ceased
- 2013-02-01 WO PCT/IB2013/050870 patent/WO2013114332A1/en active Application Filing
- 2013-02-01 MY MYPI2014702122A patent/MY170524A/en unknown
- 2013-02-01 US US14/376,307 patent/US9266876B2/en active Active
- 2013-02-01 PL PL13712913T patent/PL2809668T3/pl unknown
- 2013-02-01 EP EP13712913.6A patent/EP2809668B1/en active Active
- 2013-02-01 MX MX2014009355A patent/MX352181B/es active IP Right Grant
- 2013-02-01 ES ES13712913.6T patent/ES2632237T3/es active Active
- 2013-02-01 SG SG11201404144PA patent/SG11201404144PA/en unknown
- 2013-02-01 JP JP2014555374A patent/JP6073931B2/ja active Active
- 2013-02-01 KR KR1020147024508A patent/KR101800607B1/ko active IP Right Grant
- 2013-02-01 CA CA2861020A patent/CA2861020C/en active Active
- 2013-02-01 EA EA201400854A patent/EA027595B1/ru not_active IP Right Cessation
- 2013-02-01 UA UAA201409420A patent/UA113638C2/uk unknown
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2014
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- 2014-07-30 IL IL233872A patent/IL233872A/en not_active IP Right Cessation
- 2014-07-31 CL CL2014002048A patent/CL2014002048A1/es unknown
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2015
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Also Published As
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BR112014018714A8 (pt) | 2017-12-26 |
IL233872A (en) | 2017-05-29 |
CN104093715A (zh) | 2014-10-08 |
PL2809668T3 (pl) | 2018-02-28 |
EA201400854A1 (ru) | 2015-04-30 |
CL2014002048A1 (es) | 2014-11-14 |
ES2632237T3 (es) | 2017-09-12 |
PH12014501540B1 (en) | 2014-09-22 |
WO2013114332A1 (en) | 2013-08-08 |
MY170524A (en) | 2019-08-09 |
JP2015506957A (ja) | 2015-03-05 |
BR112014018714A2 (es) | 2017-06-20 |
CN104093715B (zh) | 2017-04-26 |
HK1203939A1 (en) | 2015-11-06 |
KR101800607B1 (ko) | 2017-11-23 |
NZ629795A (en) | 2016-06-24 |
SG11201404144PA (en) | 2014-10-30 |
MX2014009355A (es) | 2014-09-01 |
PH12014501540A1 (en) | 2014-09-22 |
EP2809668A1 (en) | 2014-12-10 |
AU2013216354A1 (en) | 2014-09-25 |
EA027595B1 (ru) | 2017-08-31 |
EP2809668B1 (en) | 2017-04-12 |
CA2861020A1 (en) | 2013-08-08 |
UA113638C2 (xx) | 2017-02-27 |
US9266876B2 (en) | 2016-02-23 |
US20140371204A1 (en) | 2014-12-18 |
CA2861020C (en) | 2018-07-17 |
JP6073931B2 (ja) | 2017-02-01 |
AU2013216354B2 (en) | 2017-08-31 |
KR20140120364A (ko) | 2014-10-13 |
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