AR111689A1 - Tienopiridinas y benzotiofenos útiles como inhibidores de irak4 - Google Patents
Tienopiridinas y benzotiofenos útiles como inhibidores de irak4Info
- Publication number
- AR111689A1 AR111689A1 ARP180101237A ARP180101237A AR111689A1 AR 111689 A1 AR111689 A1 AR 111689A1 AR P180101237 A ARP180101237 A AR P180101237A AR P180101237 A ARP180101237 A AR P180101237A AR 111689 A1 AR111689 A1 AR 111689A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- alkyl
- fluoroalkyl
- attached
- fluoroalkoxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1), o una sal o un profármaco de aquel, en donde: X es CR⁴ o N; Y es CR⁵ o N; siempre que solo uno de X e Y sea N; R¹ es un compuesto del grupo de fórmulas (2); cada R¹ᵃ es independientemente H, -OH, F, C₁₋₃ alquilo, C₁₋₃ fluoroalquilo, C₁₋₃ alcoxi, C₁₋₃ fluoroalcoxi o C₃₋₆ cicloalquilo; o dos R¹ᵃ, junto con el átomo de carbono al que están unidos, pueden formar un anillo de espirocicloalquilo de 3 a 4 miembros; cada R¹ᵇ es independientemente H, -OH, F, C₁₋₃ alquilo, C₁₋₃ fluoroalquilo, C₁₋₃ alcoxi, C₁₋₃ fluoroalcoxi o C₃₋₆ cicloalquilo; o dos R¹ᵇ, junto con el átomo de carbono al que están unidos, pueden formar un anillo de espirocicloalquilo de 3 a 4 miembros; cada R¹ᶜ es independientemente H, -OH, F, C₁₋₃ alquilo, C₁₋₃ fluoroalquilo, C₁₋₃ alcoxi, C₁₋₃ fluoroalcoxi o C₃₋₆, cicloalquilo; o dos R¹ᶜ, junto con el átomo de carbono al que están unidos, pueden formar un anillo de espirocicloalquilo de 3 a 4 miembros; R¹ᵃ y R¹ᵇ, junto con los átomos de carbono a los que están unidos, pueden formar un anillo de cicloalquilo de 3 a 4 miembros; R¹ᵇ y R¹ᶜ, junto con los átomos de carbono a los que están unidos, pueden formar un anillo de cicloalquilo de 3 a 4 miembros; R² es H, halo, C₁₋₃ alquilo o C₃₋₆ cicloalquilo; R³ es C₁₋₄ alcoxi, C₁₋₄ fluoroalcoxi o C₃₋₆ cicloalcoxi; R⁴ es H, halo, C₁₋₄ alquilo, C₁₋₄ fluoroalquilo o C₃₋₆ cicloalquilo; y R⁵ es H, halo, C₁₋₄ alquilo, C₁₋₄ fluoroalquilo o C₃₋₆ cicloalquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762504956P | 2017-05-11 | 2017-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111689A1 true AR111689A1 (es) | 2019-08-07 |
Family
ID=62245511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101237A AR111689A1 (es) | 2017-05-11 | 2018-05-10 | Tienopiridinas y benzotiofenos útiles como inhibidores de irak4 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10829496B2 (es) |
| EP (1) | EP3621960B1 (es) |
| JP (1) | JP7154229B2 (es) |
| KR (1) | KR102604900B1 (es) |
| CN (1) | CN110612298B (es) |
| AR (1) | AR111689A1 (es) |
| AU (1) | AU2018265130B2 (es) |
| BR (1) | BR112019023290A2 (es) |
| CA (1) | CA3062602A1 (es) |
| CL (1) | CL2019003198A1 (es) |
| CO (1) | CO2019012494A2 (es) |
| CY (1) | CY1124552T1 (es) |
| DK (1) | DK3621960T3 (es) |
| EA (1) | EA039189B1 (es) |
| ES (1) | ES2889926T3 (es) |
| HR (1) | HRP20211583T1 (es) |
| HU (1) | HUE056493T2 (es) |
| IL (1) | IL270494B (es) |
| LT (1) | LT3621960T (es) |
| MX (1) | MX2019012929A (es) |
| PE (1) | PE20191817A1 (es) |
| PL (1) | PL3621960T3 (es) |
| PT (1) | PT3621960T (es) |
| RS (1) | RS62430B1 (es) |
| SI (1) | SI3621960T1 (es) |
| TW (1) | TW201900640A (es) |
| WO (1) | WO2018209012A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| JP2021508703A (ja) | 2017-12-26 | 2021-03-11 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| TW202115086A (zh) | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
| KR20220041124A (ko) * | 2019-07-23 | 2022-03-31 | 브리스톨-마이어스 스큅 컴퍼니 | Irak4 억제제로서 유용한 티에노피리디닐 및 티아졸로피리디닐 화합물 |
| US11779578B2 (en) | 2019-12-17 | 2023-10-10 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN111285844B (zh) * | 2020-02-24 | 2022-08-12 | 河南师范大学 | 具有生物活性的苯并噻吩取代酰胺类化合物及其合成方法和应用 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
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-
2018
- 2018-05-10 LT LTEPPCT/US2018/031945T patent/LT3621960T/lt unknown
- 2018-05-10 AU AU2018265130A patent/AU2018265130B2/en not_active Expired - Fee Related
- 2018-05-10 BR BR112019023290-7A patent/BR112019023290A2/pt not_active Application Discontinuation
- 2018-05-10 RS RS20211247A patent/RS62430B1/sr unknown
- 2018-05-10 SI SI201830426T patent/SI3621960T1/sl unknown
- 2018-05-10 EP EP18727589.6A patent/EP3621960B1/en active Active
- 2018-05-10 PE PE2019002310A patent/PE20191817A1/es unknown
- 2018-05-10 KR KR1020197036216A patent/KR102604900B1/ko active IP Right Grant
- 2018-05-10 ES ES18727589T patent/ES2889926T3/es active Active
- 2018-05-10 JP JP2019561740A patent/JP7154229B2/ja active Active
- 2018-05-10 MX MX2019012929A patent/MX2019012929A/es unknown
- 2018-05-10 US US16/612,478 patent/US10829496B2/en active Active
- 2018-05-10 HR HRP20211583TT patent/HRP20211583T1/hr unknown
- 2018-05-10 CN CN201880031240.4A patent/CN110612298B/zh active Active
- 2018-05-10 HU HUE18727589A patent/HUE056493T2/hu unknown
- 2018-05-10 TW TW107115845A patent/TW201900640A/zh unknown
- 2018-05-10 EA EA201992674A patent/EA039189B1/ru unknown
- 2018-05-10 AR ARP180101237A patent/AR111689A1/es unknown
- 2018-05-10 WO PCT/US2018/031945 patent/WO2018209012A1/en unknown
- 2018-05-10 DK DK18727589.6T patent/DK3621960T3/da active
- 2018-05-10 PL PL18727589T patent/PL3621960T3/pl unknown
- 2018-05-10 CA CA3062602A patent/CA3062602A1/en active Pending
- 2018-05-10 PT PT187275896T patent/PT3621960T/pt unknown
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2019
- 2019-11-07 CO CONC2019/0012494A patent/CO2019012494A2/es unknown
- 2019-11-07 IL IL270494A patent/IL270494B/en unknown
- 2019-11-07 CL CL2019003198A patent/CL2019003198A1/es unknown
-
2021
- 2021-10-07 CY CY20211100874T patent/CY1124552T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3621960B1 (en) | 2021-08-04 |
| CN110612298B (zh) | 2023-05-05 |
| EA039189B1 (ru) | 2021-12-15 |
| HRP20211583T1 (hr) | 2022-01-07 |
| HUE056493T2 (hu) | 2022-02-28 |
| ES2889926T3 (es) | 2022-01-14 |
| TW201900640A (zh) | 2019-01-01 |
| EA201992674A1 (ru) | 2020-04-06 |
| CA3062602A1 (en) | 2018-11-15 |
| US20200062777A1 (en) | 2020-02-27 |
| DK3621960T3 (da) | 2021-09-27 |
| WO2018209012A1 (en) | 2018-11-15 |
| KR102604900B1 (ko) | 2023-11-21 |
| BR112019023290A2 (pt) | 2020-06-16 |
| SI3621960T1 (sl) | 2021-11-30 |
| JP2020519596A (ja) | 2020-07-02 |
| PL3621960T3 (pl) | 2021-11-08 |
| PT3621960T (pt) | 2021-09-16 |
| PE20191817A1 (es) | 2019-12-27 |
| JP7154229B2 (ja) | 2022-10-17 |
| CL2019003198A1 (es) | 2020-03-20 |
| MX2019012929A (es) | 2020-01-14 |
| AU2018265130B2 (en) | 2022-03-24 |
| CO2019012494A2 (es) | 2020-01-17 |
| US10829496B2 (en) | 2020-11-10 |
| EP3621960A1 (en) | 2020-03-18 |
| AU2018265130A1 (en) | 2020-01-02 |
| CN110612298A (zh) | 2019-12-24 |
| CY1124552T1 (el) | 2022-07-22 |
| IL270494B (en) | 2022-04-01 |
| LT3621960T (lt) | 2021-10-11 |
| KR20200004871A (ko) | 2020-01-14 |
| RS62430B1 (sr) | 2021-11-30 |
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