AR102204A1 - Compuestos derivados de amino-alquilbenzotiazepinas - Google Patents

Compuestos derivados de amino-alquilbenzotiazepinas

Info

Publication number
AR102204A1
AR102204A1 ARP150103242A ARP150103242A AR102204A1 AR 102204 A1 AR102204 A1 AR 102204A1 AR P150103242 A ARP150103242 A AR P150103242A AR P150103242 A ARP150103242 A AR P150103242A AR 102204 A1 AR102204 A1 AR 102204A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
carboxy
carbamoyl
sulfamoyloxy
Prior art date
Application number
ARP150103242A
Other languages
English (en)
Original Assignee
Cj Healthcare Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Healthcare Corp filed Critical Cj Healthcare Corp
Publication of AR102204A1 publication Critical patent/AR102204A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/24Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a seven-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/02Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/06Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

La presente solicitud se refiere a un derivado de aminoalquilbenzotiazepina o a una sal aceptable para uso farmacéutico del mismo y a una composición farmacéutica para prevenir o tratar el estreñimiento que comprende el mismo como un principio activo. Reivindicación 1: Un compuesto representado por la fórmula (1) o una sal aceptable para uso farmacéutico del mismo, en la que R¹ es hidroxi, carboxi o hidroxisulfonil(alquilo C₁₋₄); R² y R³ son cada uno independientemente hidrógeno, alquilo C₁₋₄, hidroxi(alquilo C₁₋₄), carbamoil(alquilo C₁₋₄), carboxi, carboxi(alquilo C₁₋₄), (heteroarilo C₅₋₁₀)(alquilo C₁₋₄) o (arilo C₅₋₁₀)(alquilo C₁₋₄) o R² y R³, considerados juntos con el átomo de carbono respectivo al que están unidos, forman cicloalquileno C₃₋₇; R⁴ es hidrógeno carboxi(alquilo C₁₋₄); R⁵ es hidrógeno, halógeno, (alquil C₁₋₄)tio, (alquil C₁₋₄)amino o di(alquil C₁₋₄)amino; R⁶ y R⁷ son cada uno independientemente alquilo C₁₋₆; R⁸ y R⁹ son cada uno independientemente hidrógeno, hidroxi, alcoxi C₁₋₄, alquilo C₁₋₄, halógeno, nitro, ciano, amino, (alquil C₁₋₄)amino, di(alquil C₁₋₄)amino, acetamido, formilo, alcanoilo C₁₋₄, carboxi, carbamoílo, (alquil C₁₋₄)carbamoílo, di(alquil C₁₋₄)carbamoílo, carbamoíloxi, (alquil C₁₋₄)carbamoíloxi, di(alquil C₁₋₄)carbamoiloxi, (alquil C₁₋₄)sulfoniloxi, sulfamoiloxi, (alquil C₁₋₄)sulfamoiloxi o di(alquil C₁₋₄)sulfamoiloxi; Q es arilo C₅₋₁₀ o heteroarilo C₅₋₁₀; y n es un número entero de 0 a 3.
ARP150103242A 2014-10-20 2015-10-07 Compuestos derivados de amino-alquilbenzotiazepinas AR102204A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20140141869 2014-10-20

Publications (1)

Publication Number Publication Date
AR102204A1 true AR102204A1 (es) 2017-02-08

Family

ID=56021635

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103242A AR102204A1 (es) 2014-10-20 2015-10-07 Compuestos derivados de amino-alquilbenzotiazepinas

Country Status (15)

Country Link
US (1) US9890129B2 (es)
EP (1) EP3210977B1 (es)
JP (1) JP6386171B2 (es)
KR (1) KR101674806B1 (es)
CN (1) CN106573902B (es)
AR (1) AR102204A1 (es)
AU (1) AU2015336400B8 (es)
CA (1) CA2951824C (es)
DK (1) DK3210977T3 (es)
ES (1) ES2729305T3 (es)
IL (1) IL250668B (es)
MX (1) MX2016016593A (es)
RU (1) RU2679891C2 (es)
UY (1) UY36342A (es)
WO (1) WO2016064082A2 (es)

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CA2952406A1 (en) 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for preventing or reducing coloration thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
KR101844184B1 (ko) 2017-07-21 2018-04-02 씨제이헬스케어 주식회사 아미노알킬벤조티아제핀 유도체의 용도
EP3802504B1 (en) 2018-06-05 2023-01-18 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11802115B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
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US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
JP2023504647A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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AR120683A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzoti(di)azepina y su uso como ácido biliar
JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
AR120676A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzoti(di)azepina y su uso como ácido biliar
CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
IL293379A (en) 2019-12-04 2022-07-01 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202134223A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
AR120674A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzotiazepina y su uso como ácido biliar
WO2021110885A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CA3186857A1 (en) 2020-08-03 2022-02-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
KR20230106651A (ko) 2020-11-12 2023-07-13 알비레오 에이비 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트
CN116583504A (zh) 2020-12-04 2023-08-11 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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Also Published As

Publication number Publication date
US20170283386A1 (en) 2017-10-05
RU2017103920A3 (es) 2018-11-22
CA2951824C (en) 2019-01-08
RU2679891C2 (ru) 2019-02-14
UY36342A (es) 2016-06-01
RU2017103920A (ru) 2018-11-22
IL250668B (en) 2019-07-31
US9890129B2 (en) 2018-02-13
KR20160047378A (ko) 2016-05-02
JP6386171B2 (ja) 2018-09-05
WO2016064082A3 (ko) 2016-06-09
JP2017527589A (ja) 2017-09-21
BR112016030599A8 (pt) 2021-07-06
AU2015336400A8 (en) 2018-04-05
IL250668A0 (en) 2017-04-30
EP3210977A4 (en) 2018-04-11
CN106573902A (zh) 2017-04-19
WO2016064082A2 (ko) 2016-04-28
CN106573902B (zh) 2019-10-08
EP3210977A2 (en) 2017-08-30
AU2015336400B8 (en) 2018-04-05
ES2729305T3 (es) 2019-10-31
CA2951824A1 (en) 2016-04-28
AU2015336400A1 (en) 2016-12-22
MX2016016593A (es) 2017-04-27
AU2015336400B2 (en) 2017-12-07
KR101674806B1 (ko) 2016-11-10
BR112016030599A2 (pt) 2017-08-15
EP3210977B1 (en) 2019-03-20
DK3210977T3 (da) 2019-07-01

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