SV2018005655A - "derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer" - Google Patents

"derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer"

Info

Publication number
SV2018005655A
SV2018005655A SV2018005655A SV2018005655A SV2018005655A SV 2018005655 A SV2018005655 A SV 2018005655A SV 2018005655 A SV2018005655 A SV 2018005655A SV 2018005655 A SV2018005655 A SV 2018005655A SV 2018005655 A SV2018005655 A SV 2018005655A
Authority
SV
El Salvador
Prior art keywords
quinolin
atm
compounds
ona
cancer
Prior art date
Application number
SV2018005655A
Other languages
English (en)
Inventor
Kurt Gordon Pike
Bernard Christophe Barlaam
Thomas Anthony Hunt
Andrew John Eatherton
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SV2018005655A publication Critical patent/SV2018005655A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

LA MEMORIA DESCRIPTIVA SE REFIERE EN GENERAL A COMPUESTOS DE FÓRMULA (I): (VER FORMULA) Y SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTOS, DONDE R1, R2, R3, R4 Y R5 TIENEN CUALQUIERA DE LOS SIGNIFICADOS DEFINIDOS EN LA PRESENTE. LA MEMORIA DESCRIPTIVA TAMBIÉN SE REFIERE AL USO DE COMPUESTOS DE FÓRMULA (I) Y SALES DE ESTOS PARA TRATAR O PREVENIR UNA ENFERMEDAD MEDIADA POR ATM, INCLUIDO EL CÁNCER. LA MEMORIA DESCRIPTIVA SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE TIPO IMIDAZO[4,5-C]QUINOLIN-2-ONA SUSTITUIDOS Y SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTOS; KITS QUE COMPRENDEN TALES COMPUESTOS Y SALES; MÉTODOS DE PRODUCCIÓN DE TALES COMPUESTOS Y SALES; E INTERMEDIOS ÚTILES EN TAL PRODUCCIÓN
SV2018005655A 2015-09-17 2018-03-16 "derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer" SV2018005655A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1516504.6A GB201516504D0 (en) 2015-09-17 2015-09-17 Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer

Publications (1)

Publication Number Publication Date
SV2018005655A true SV2018005655A (es) 2018-04-27

Family

ID=54544418

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2018005655A SV2018005655A (es) 2015-09-17 2018-03-16 "derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer"

Country Status (37)

Country Link
US (5) US9856255B2 (es)
EP (2) EP3683220B1 (es)
JP (1) JP6605130B2 (es)
KR (2) KR102469153B1 (es)
CN (1) CN108137576B (es)
AR (1) AR106053A1 (es)
AU (1) AU2016323399B2 (es)
BR (1) BR112018004325B1 (es)
CA (1) CA2997399C (es)
CL (1) CL2018000677A1 (es)
CO (1) CO2018002829A2 (es)
CR (1) CR20180172A (es)
CY (1) CY1124680T1 (es)
DK (2) DK3683220T3 (es)
DO (1) DOP2018000065A (es)
EA (1) EA033284B1 (es)
ES (2) ES2853924T3 (es)
GB (1) GB201516504D0 (es)
HK (2) HK1255408A1 (es)
HR (1) HRP20210149T1 (es)
HU (2) HUE058884T2 (es)
IL (1) IL257847B (es)
LT (1) LT3350180T (es)
MX (1) MX2018003186A (es)
MY (1) MY195669A (es)
NI (1) NI201800033A (es)
PE (1) PE20181078A1 (es)
PH (1) PH12018500532A1 (es)
PL (2) PL3683220T3 (es)
PT (2) PT3350180T (es)
RS (1) RS61435B1 (es)
SI (1) SI3350180T1 (es)
SV (1) SV2018005655A (es)
TN (1) TN2018000078A1 (es)
TW (2) TWI714631B (es)
WO (1) WO2017046216A1 (es)
ZA (1) ZA202209171B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CN111344293A (zh) 2017-09-20 2020-06-26 阿斯利康(瑞典)有限公司 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途
KR20210061337A (ko) 2018-09-14 2021-05-27 수저우 잔롱 파마 리미티드 모세혈관확장성 운동실조증 돌연변이(ATM) 키나제의 선택적 조절제로서의 1-이소프로필-3-메틸-8-(피리딘-3-일)-1,3-디하이드로-2H-이미다조[4,5-c]신놀린-2-온 및 이의 용도
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
EP4115883A4 (en) * 2020-03-04 2024-04-10 Pharos Ibio Co Ltd USE OF A 2,3,5-SUBSTITUTED THIOPHENE COMPOUND TO PREVENT, MITIGATE OR TREAT OVARIAN CANCER
TW202216209A (zh) 2020-06-24 2022-05-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及atm抑制劑之組合
WO2022063303A1 (zh) * 2020-09-28 2022-03-31 石药集团中奇制药技术（石家庄）有限公司 一类并环化合物及其制备和应用
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022125614A1 (en) * 2020-12-09 2022-06-16 Stingray Therapeutics, Inc. Phosphonates as inhibitors of enpp1 and cdnp
AU2021433713A1 (en) * 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598A (zh) * 2021-08-25 2022-11-08 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
WO2023143282A1 (zh) * 2022-01-26 2023-08-03 正大天晴药业集团股份有限公司 含有肼基的化合物
WO2023200427A1 (en) * 2022-04-11 2023-10-19 Wei Zhong Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one derivative crystal form, salt crystal form, preparation method and application

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2094139A1 (en) 1990-10-22 1992-04-23 Frederick W. Wassmundt Aryl and heteroaryl compounds having anti-retrovirus activity
TW301607B (es) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
TR199801530T2 (xx) 1996-02-13 1998-11-23 Zeneca Limited VEGF �nhibit�rleri olarak kinazolin t�revleri.
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
WO2000007595A1 (en) 1998-08-03 2000-02-17 Basf Corporation Pyridinones for the treatment of sexual dysfunction
CA2362401A1 (en) 1999-02-04 2000-08-10 Paul Fleming G-protein coupled heptahelical receptor binding compounds and methods of use thereof
US20020151712A1 (en) 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
WO2002030357A2 (en) 2000-10-11 2002-04-18 Chemocentryx, Inc. Compounds and methods for modulating ccr4 function
WO2002030358A2 (en) 2000-10-11 2002-04-18 Tularik Inc. Modulation of ccr4 function
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
AU2002303156A1 (en) 2001-03-23 2002-10-08 Bethesda Pharmaceuticals, Inc. Design and synthesis of optimized ligands for ppar
JP2002293745A (ja) 2001-03-29 2002-10-09 St Marianna Univ School Of Medicine 慢性関節リウマチ治療剤
CA2442654A1 (en) 2001-04-10 2002-10-10 Transtech Pharma, Inc. Probes, systems, and methods for drug discovery
US20040116330A1 (en) 2001-04-27 2004-06-17 Kenichiro Naito Preventive/therapeutic method for cancer
US7144903B2 (en) 2001-05-23 2006-12-05 Amgen Inc. CCR4 antagonists
EP1270535A3 (de) 2001-06-20 2004-02-18 Clariant GmbH Verfahren zur Herstellung von substituierten aromatischen Verbindungen
JP4082888B2 (ja) 2001-10-17 2008-04-30 広栄化学工業株式会社 ビアリール化合物の製造法
EP1513522A2 (en) 2002-01-18 2005-03-16 Sri International Methods of treating conditions associated with an edg receptor
JP4167848B2 (ja) 2002-04-10 2008-10-22 広栄化学工業株式会社 ビアリール化合物の製造法
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
WO2004007472A1 (ja) 2002-07-10 2004-01-22 Ono Pharmaceutical Co., Ltd. Ｃｃｒ４アンタゴニストおよびその医薬用途
JP2005536554A (ja) 2002-08-23 2005-12-02 ユニバーシティ オブ コネチカット 新規なビフェニル及びビフェニル様カンナビノイド
CN1678303A (zh) 2002-08-23 2005-10-05 康涅狄格大学 具有治疗作用的酮类大麻类
US7432375B2 (en) * 2003-03-06 2008-10-07 Eisai R & D Management Co., Ltd. JNK inhibitors
JPWO2004080943A1 (ja) 2003-03-11 2006-06-08 小野薬品工業株式会社 シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤
WO2004113258A1 (ja) 2003-06-20 2004-12-29 Shionogi & Co., Ltd. 炭素−炭素結合生成反応
EP1661889A4 (en) 2003-09-05 2009-08-05 Ono Pharmaceutical Co ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
CN1902200A (zh) 2003-11-21 2007-01-24 诺瓦提斯公司 用做蛋白激酶抑制剂的1h－咪唑并喹啉类衍生物
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
KR101262400B1 (ko) 2004-12-13 2013-05-08 오노 야꾸힝 고교 가부시키가이샤 아미노카르복실산 유도체 및 그 의약 용도
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20070032522A1 (en) 2005-07-01 2007-02-08 Kumar Dange V Antiviral agents
EP1962861A2 (en) 2005-08-26 2008-09-03 Emory University Compounds and methods for modulating the silencing of a polynucleotide of interest
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
CL2008000191A1 (es) 2007-01-25 2008-08-22 Astrazeneca Ab Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
CN101616672A (zh) 2007-02-20 2009-12-30 诺瓦提斯公司 作为脂质激酶和mTOR双重抑制剂的咪唑并喹啉类
CA2680177A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9321730B2 (en) 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
BRPI0909082A2 (pt) 2008-03-26 2019-02-26 Novartis Ag imidazoquinolinas e derivados de pirimidina como moduladores potentes de processos angiogênicos acionados por vegf
US8841462B2 (en) 2008-07-01 2014-09-23 Robert A. Heald Bicyclic heterocycles as MEK kinase inhibitors
TW201028381A (en) 2008-07-14 2010-08-01 Shionogi & Co Pyridine derivative having ttk inhibition activity
US8791131B2 (en) 2008-09-30 2014-07-29 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
CA2746220A1 (en) 2008-12-08 2010-07-08 Vm Pharma Llc Compositions of protein receptor tyrosine kinase inhibitors
US20120093917A1 (en) 2009-04-02 2012-04-19 Robert Hromas Metnase and intnase inhibitors and their use in treating cancer
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EP2438064A1 (en) * 2009-06-04 2012-04-11 Novartis AG 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES
EP2438063A1 (en) * 2009-06-04 2012-04-11 Novartis AG 1h-imidazo[4,5-c]quinolinone compounds, useful for the treatment of proliferative diseases
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
US20120046272A1 (en) 2010-08-23 2012-02-23 Grunenthal Gmbh Novel Therapeutic Compounds
DE102010035744A1 (de) 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
AR083267A1 (es) 2010-10-04 2013-02-13 Novartis Ag Combinaciones farmaceuticas
PE20140792A1 (es) 2010-12-03 2014-07-09 Novartis Ag Composiciones farmaceuticas
JP2014504286A (ja) 2010-12-06 2014-02-20 ピラマル エンタープライジーズ リミテッド 置換イミダゾキノリン誘導体
WO2012083866A1 (en) 2010-12-22 2012-06-28 The Hong Kong Polytechnic University Quinoline derivatives as anti-cancer agents
US8883793B2 (en) 2010-12-29 2014-11-11 Development Center For Biotechnology Tubulin inhibitors and methods of using the same
JO3003B1 (ar) * 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
EP2694678A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
KR20140041583A (ko) 2011-05-23 2014-04-04 엘란 파마슈티컬스, 엘엘씨 Ｌｒｒｋ2 키나제 활성의 억제제
CA2837312A1 (en) 2011-05-26 2012-11-29 Sunovion Pharmaceuticals Inc. Metabotropic glutamate receptor 5 allosteric modulators and methods of use thereof
WO2013022740A2 (en) 2011-08-05 2013-02-14 Corning Incorporated Gpr35 ligands and the uses thereof
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
AU2012335980C1 (en) 2011-11-07 2017-12-14 Sunovion Pharmaceuticals Inc. Modulators of opioid receptors and methods of use thereof
WO2013074965A1 (en) 2011-11-16 2013-05-23 Microbiotix, Inc. Aminoalkyl phenol ether inhibitors of influenza a virus
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN104349771A (zh) 2012-06-06 2015-02-11 诺华股份有限公司 用于治疗肿瘤疾病的17α-羟化酶(C17,20-裂解酶)抑制剂和特定PI-3K抑制剂的组合
AU2013271731A1 (en) 2012-06-07 2014-12-18 Georgia State University Research Foundation, Inc. SecA inhibitors and methods of making and using thereof
WO2013192367A1 (en) 2012-06-22 2013-12-27 Novartis Ag Neuroendocrine tumor treatment
CN105050623B (zh) 2012-08-16 2018-06-12 诺华股份有限公司 Pi3k抑制剂和c-met抑制剂的组合
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
US9713612B2 (en) 2013-03-12 2017-07-25 Curegenix, Inc. Compounds for treatment of cancer
GB201309180D0 (en) 2013-05-21 2013-07-03 Ucl Business Plc Compounds and Their Uses
WO2015073804A2 (en) 2013-11-15 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of blocking transmission of malarial parasite
WO2015084384A1 (en) * 2013-12-06 2015-06-11 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
NO2714752T3 (es) * 2014-05-08 2018-04-21
GB201409044D0 (en) 2014-05-21 2014-07-02 Ucl Business Plc New compounds
ES2880626T3 (es) 2015-04-02 2021-11-25 Merck Patent Gmbh Imidazolonilquinolinas
CN104876912B (zh) 2015-04-08 2017-07-21 苏州云轩医药科技有限公司 Wnt信号通路抑制剂及其应用
WO2017011323A1 (en) 2015-07-10 2017-01-19 University Of Maryland, Baltimore Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
EP3429591B1 (en) 2016-03-16 2023-03-15 Kura Oncology, Inc. Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use

Also Published As

Publication number Publication date
US10457679B2 (en) 2019-10-29
RS61435B1 (sr) 2021-03-31
EA201890650A1 (ru) 2018-10-31
PT3683220T (pt) 2022-06-24
HUE058884T2 (hu) 2022-09-28
TWI714631B (zh) 2021-01-01
TWI762109B (zh) 2022-04-21
JP6605130B2 (ja) 2019-11-13
WO2017046216A1 (en) 2017-03-23
US20180141943A1 (en) 2018-05-24
KR102469153B1 (ko) 2022-11-22
AU2016323399A1 (en) 2018-05-10
IL257847A (en) 2018-04-30
TW202124381A (zh) 2021-07-01
BR112018004325B1 (pt) 2023-10-17
PT3350180T (pt) 2021-02-08
US9856255B2 (en) 2018-01-02
CN108137576B (zh) 2020-09-22
CL2018000677A1 (es) 2018-08-17
AR106053A1 (es) 2017-12-06
JP2018531226A (ja) 2018-10-25
CY1124680T1 (el) 2022-07-22
PE20181078A1 (es) 2018-07-05
KR20190112852A (ko) 2019-10-07
LT3350180T (lt) 2021-02-25
HRP20210149T1 (hr) 2021-03-19
PL3683220T3 (pl) 2022-08-01
ES2853924T3 (es) 2021-09-20
CO2018002829A2 (es) 2018-05-31
US20230286981A1 (en) 2023-09-14
CR20180172A (es) 2018-05-25
US20170081325A1 (en) 2017-03-23
PH12018500532A1 (en) 2018-08-29
CA2997399A1 (en) 2017-03-23
US11613539B2 (en) 2023-03-28
PL3350180T3 (pl) 2021-05-17
MY195669A (en) 2023-02-03
SI3350180T1 (sl) 2021-03-31
ES2920876T3 (es) 2022-08-11
DK3350180T3 (da) 2021-02-15
DOP2018000065A (es) 2018-03-30
DK3683220T3 (da) 2022-07-04
US20210147416A1 (en) 2021-05-20
AU2016323399B2 (en) 2019-04-18
US20200102302A1 (en) 2020-04-02
GB201516504D0 (en) 2015-11-04
TW201722946A (zh) 2017-07-01
EP3683220A1 (en) 2020-07-22
US10882858B2 (en) 2021-01-05
IL257847B (en) 2020-08-31
HK1255408A1 (zh) 2019-08-16
KR102028848B1 (ko) 2019-10-04
EA033284B1 (ru) 2019-09-30
TN2018000078A1 (en) 2019-07-08
HUE053066T2 (hu) 2021-06-28
CN108137576A (zh) 2018-06-08
HK1257413A1 (zh) 2019-10-18
EP3350180A1 (en) 2018-07-25
ZA202209171B (en) 2023-11-29
NI201800033A (es) 2018-10-18
EP3350180B1 (en) 2020-11-11
EP3683220B1 (en) 2022-04-13
MX2018003186A (es) 2018-05-17
CA2997399C (en) 2024-02-20
BR112018004325A2 (es) 2018-10-02
KR20180052724A (ko) 2018-05-18

Similar Documents

Publication Publication Date Title
SV2018005655A (es) "derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer"
SV2018005663A (es) Compuestos de imidazo [4,5-c] quinolin-2-ona y su uso en el tratamiento del cancer
SV2018005680A (es) Compuestos de imidazo [4,5-c] quinolin- 2-ona y su uso en el tratamiento del cancer
CL2019001714A1 (es) Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer.
DOP2016000281A (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
CL2017001426A1 (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
CO2018004857A2 (es) Derivados de dihidroimidazopirazinona usados en el tratamiento del cáncer
CR20150472A (es) USO DE DERIVADOS DE PIRAZOLOPIRIMIDINA PARA EL TRATAMIENTO DE TRANSTORNOS RELACIONADOS CON LA PI3Kd
AR108461A1 (es) Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer
AR100431A1 (es) Compuestos de pladienolida piridina y métodos de uso
NI201600176A (es) Compuestos de 1, 3, 4 - tiadiazol y uso de los mismos para el tratamiento del cáncer.
CL2019002900A1 (es) Análogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton.
CL2019002527A1 (es) Compuestos de tipo imidazo[4,5-c]quinolin-2-ona deuterados y su uso en el tratamiento del cáncer.
CO2018010951A2 (es) Compuestos de cinnolin-4-amina y su uso en el tratamiento del cáncer
MX2015012153A (es) Inhibidores de la quinasa pirrolopirimidina cdk9.