CR20180172A - Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer - Google Patents
Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncerInfo
- Publication number
- CR20180172A CR20180172A CR20180172A CR20180172A CR20180172A CR 20180172 A CR20180172 A CR 20180172A CR 20180172 A CR20180172 A CR 20180172A CR 20180172 A CR20180172 A CR 20180172A CR 20180172 A CR20180172 A CR 20180172A
- Authority
- CR
- Costa Rica
- Prior art keywords
- quinolin
- atm
- isopropilimidazo
- propoxi
- piridil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La memoria descriptiva se refiere en general a compuestos de Fórmula y sales farmacéuticamente aceptables de estos, donde R1, R2, R3, R4 y R5 tienen cualquiera de los significados definidos en la presente. La memoria descriptiva también se refiere al uso de compuestos de Fórmula (I) y sales de estos para tratar o prevenir una enfermedad mediada por ATM, incluido el cáncer. La memoria descriptiva se refiere además a composiciones farmacéuticas que comprenden compuestos de tipo imidazo[4,5-c]quinolin-2-ona sustituidos y sales farmacéuticamente aceptables de estos; kits que comprenden tales compuestos y sales; métodos de producción de tales compuestos y sales; e intermedios útiles en tal producción
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1516504.6A GB201516504D0 (en) | 2015-09-17 | 2015-09-17 | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
PCT/EP2016/071782 WO2017046216A1 (en) | 2015-09-17 | 2016-09-15 | 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
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CR20180172A true CR20180172A (es) | 2018-05-25 |
Family
ID=54544418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20180172A CR20180172A (es) | 2015-09-17 | 2016-09-15 | Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer |
Country Status (37)
Country | Link |
---|---|
US (5) | US9856255B2 (es) |
EP (2) | EP3350180B1 (es) |
JP (1) | JP6605130B2 (es) |
KR (2) | KR102469153B1 (es) |
CN (1) | CN108137576B (es) |
AR (1) | AR106053A1 (es) |
AU (1) | AU2016323399B2 (es) |
BR (1) | BR112018004325B1 (es) |
CA (1) | CA2997399C (es) |
CL (1) | CL2018000677A1 (es) |
CO (1) | CO2018002829A2 (es) |
CR (1) | CR20180172A (es) |
CY (1) | CY1124680T1 (es) |
DK (2) | DK3683220T3 (es) |
DO (1) | DOP2018000065A (es) |
EA (1) | EA033284B1 (es) |
ES (2) | ES2853924T3 (es) |
GB (1) | GB201516504D0 (es) |
HK (2) | HK1255408A1 (es) |
HR (1) | HRP20210149T1 (es) |
HU (2) | HUE058884T2 (es) |
IL (1) | IL257847B (es) |
LT (1) | LT3350180T (es) |
MX (1) | MX2018003186A (es) |
MY (1) | MY195669A (es) |
NI (1) | NI201800033A (es) |
PE (1) | PE20181078A1 (es) |
PH (1) | PH12018500532A1 (es) |
PL (2) | PL3350180T3 (es) |
PT (2) | PT3350180T (es) |
RS (1) | RS61435B1 (es) |
SI (1) | SI3350180T1 (es) |
SV (1) | SV2018005655A (es) |
TN (1) | TN2018000078A1 (es) |
TW (2) | TWI714631B (es) |
WO (1) | WO2017046216A1 (es) |
ZA (1) | ZA202209171B (es) |
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CN111344293A (zh) | 2017-09-20 | 2020-06-26 | 阿斯利康(瑞典)有限公司 | 1,3-二氢咪唑并[4,5-c]噌啉-2-酮化合物及其在治疗癌症中的用途 |
EP3849984A4 (en) * | 2018-09-14 | 2022-06-01 | Suzhou Zanrong Pharma Limited | 1-ISOPROPYL-3-METHYL-8-(PYRIDIN-3-YL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]CINNOLIN-2-ONE SERVING AS SELECTIVE KINASE MODULATORS ATAXIA TELANGIECTASIA (ATM ) MUTEATED AND ASSOCIATED USES |
CN115003672A (zh) * | 2020-01-09 | 2022-09-02 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
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CN104876912B (zh) | 2015-04-08 | 2017-07-21 | 苏州云轩医药科技有限公司 | Wnt信号通路抑制剂及其应用 |
WO2017011323A1 (en) | 2015-07-10 | 2017-01-19 | University Of Maryland, Baltimore | Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof |
GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
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