CN115003672A - 喹啉并咪唑类化合物及其应用 - Google Patents
喹啉并咪唑类化合物及其应用 Download PDFInfo
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- CN115003672A CN115003672A CN202180009993.7A CN202180009993A CN115003672A CN 115003672 A CN115003672 A CN 115003672A CN 202180009993 A CN202180009993 A CN 202180009993A CN 115003672 A CN115003672 A CN 115003672A
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- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
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- 229960005322 streptomycin Drugs 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一类喹啉并咪唑类化合物，具体公开了式(I)化合物及其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020100225316 | 2020-01-09 | ||
| CN202010022531 | 2020-01-09 | ||
| PCT/CN2021/071107 WO2021139814A1 (zh) | 2020-01-09 | 2021-01-11 | 喹啉并咪唑类化合物及其应用 |
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| Publication Number | Publication Date |
|---|---|
| CN115003672A true CN115003672A (zh) | 2022-09-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202180009993.7A Pending CN115003672A (zh) | 2020-01-09 | 2021-01-11 | 喹啉并咪唑类化合物及其应用 |
Country Status (2)
| Country | Link |
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| CN (1) | CN115003672A (zh) |
| WO (1) | WO2021139814A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023143282A1 (zh) * | 2022-01-26 | 2023-08-03 | 正大天晴药业集团股份有限公司 | 含有肼基的化合物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106255692A (zh) * | 2014-05-08 | 2016-12-21 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5‑c]喹啉‑2‑酮化合物以及它们在治疗癌症中的用途 |
| WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN108137576A (zh) * | 2015-09-17 | 2018-06-08 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的、为共济失调毛细血管扩张症突变型（atm）激酶的选择性调节剂的8-[6-[3-(氨基)丙氧基]-3-吡啶基]-1-异丙基-咪唑并[4,5-c]喹啉-2-酮衍生物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201911244T4 (tr) * | 2015-04-02 | 2019-08-21 | Merck Patent Gmbh | İmidazolonilkinolinler ve atm kinaz inhibitörleri olarak kullanımı. |
| GB201519406D0 (en) * | 2015-11-03 | 2015-12-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| GB201604182D0 (en) * | 2016-03-11 | 2016-04-27 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
-
2021
- 2021-01-11 WO PCT/CN2021/071107 patent/WO2021139814A1/zh active Application Filing
- 2021-01-11 CN CN202180009993.7A patent/CN115003672A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106255692A (zh) * | 2014-05-08 | 2016-12-21 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5‑c]喹啉‑2‑酮化合物以及它们在治疗癌症中的用途 |
| CN108137576A (zh) * | 2015-09-17 | 2018-06-08 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的、为共济失调毛细血管扩张症突变型（atm）激酶的选择性调节剂的8-[6-[3-(氨基)丙氧基]-3-吡啶基]-1-异丙基-咪唑并[4,5-c]喹啉-2-酮衍生物 |
| WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
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| Publication number | Publication date |
|---|---|
| WO2021139814A1 (zh) | 2021-07-15 |
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