CN114026079A - 一种sglt2/dpp4抑制剂及其应用 - Google Patents
一种sglt2/dpp4抑制剂及其应用 Download PDFInfo
- Publication number
- CN114026079A CN114026079A CN202080047668.5A CN202080047668A CN114026079A CN 114026079 A CN114026079 A CN 114026079A CN 202080047668 A CN202080047668 A CN 202080047668A CN 114026079 A CN114026079 A CN 114026079A
- Authority
- CN
- China
- Prior art keywords
- compound
- reaction
- added
- stirred
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Abstract
作为SGLT2/DPP4双抑制剂的一类化合物,以及在制备作为SGLT2/DPP4双抑制剂的药物中的应用。具体涉及式(Ⅰ)所示化合物、其异构体或其药学上可接受的盐。
Description
PCT国内申请,说明书已公开。
Claims (9)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2019106830992 | 2019-07-26 | ||
CN201910683099 | 2019-07-26 | ||
CN2020101199145 | 2020-02-26 | ||
CN202010119914 | 2020-02-26 | ||
CN202010572226 | 2020-06-22 | ||
CN2020105722264 | 2020-06-22 | ||
PCT/CN2020/104521 WO2021018044A1 (zh) | 2019-07-26 | 2020-07-24 | 一种sglt2/dpp4抑制剂及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN114026079A true CN114026079A (zh) | 2022-02-08 |
CN114026079B CN114026079B (zh) | 2022-10-18 |
Family
ID=74228349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080047668.5A Active CN114026079B (zh) | 2019-07-26 | 2020-07-24 | 一种sglt2/dpp4抑制剂及其应用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220242898A1 (zh) |
EP (1) | EP4006017A4 (zh) |
JP (1) | JP7227427B2 (zh) |
KR (1) | KR102471055B1 (zh) |
CN (1) | CN114026079B (zh) |
AU (1) | AU2020320890B2 (zh) |
CA (1) | CA3145678C (zh) |
MX (1) | MX2022001044A (zh) |
WO (1) | WO2021018044A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022160737A1 (zh) * | 2021-01-26 | 2022-08-04 | 东宝紫星(杭州)生物医药有限公司 | 四氢吡喃环类化合物的晶型及其制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101343296A (zh) * | 2007-07-10 | 2009-01-14 | 莱西肯医药有限公司 | 钠-葡萄糖协同转运蛋白2的抑制剂及其用法 |
WO2011070592A2 (en) * | 2009-12-09 | 2011-06-16 | Panacea Biotec Ltd. | Novel sugar derivatives |
CN102272136A (zh) * | 2008-11-13 | 2011-12-07 | 默沙东公司 | 作为用于糖尿病的治疗或预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃 |
CN104854096A (zh) * | 2012-11-20 | 2015-08-19 | 莱西肯医药有限公司 | 钠葡萄糖协同转运蛋白1的抑制剂 |
CN105461762A (zh) * | 2014-09-27 | 2016-04-06 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物及其在医药上的应用 |
WO2019134667A1 (zh) * | 2018-01-05 | 2019-07-11 | 南京明德新药研发股份有限公司 | 一种SGLTs抑制剂及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法 |
JP5685550B2 (ja) | 2009-02-13 | 2015-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Sglt2阻害剤、dpp−iv阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用 |
JP7299408B2 (ja) * | 2019-07-26 | 2023-06-27 | ドンバオ パープル スター (ハンチョウ) バイオファーマシューティカル シーオー.,エルティーディー. | SGLTs/DPP4阻害剤およびその使用 |
-
2020
- 2020-07-24 KR KR1020227006283A patent/KR102471055B1/ko active IP Right Grant
- 2020-07-24 CN CN202080047668.5A patent/CN114026079B/zh active Active
- 2020-07-24 AU AU2020320890A patent/AU2020320890B2/en active Active
- 2020-07-24 WO PCT/CN2020/104521 patent/WO2021018044A1/zh unknown
- 2020-07-24 CA CA3145678A patent/CA3145678C/en active Active
- 2020-07-24 EP EP20848355.2A patent/EP4006017A4/en active Pending
- 2020-07-24 JP JP2022505531A patent/JP7227427B2/ja active Active
- 2020-07-24 MX MX2022001044A patent/MX2022001044A/es unknown
- 2020-07-24 US US17/629,527 patent/US20220242898A1/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101343296A (zh) * | 2007-07-10 | 2009-01-14 | 莱西肯医药有限公司 | 钠-葡萄糖协同转运蛋白2的抑制剂及其用法 |
CN102272136A (zh) * | 2008-11-13 | 2011-12-07 | 默沙东公司 | 作为用于糖尿病的治疗或预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃 |
WO2011070592A2 (en) * | 2009-12-09 | 2011-06-16 | Panacea Biotec Ltd. | Novel sugar derivatives |
CN104854096A (zh) * | 2012-11-20 | 2015-08-19 | 莱西肯医药有限公司 | 钠葡萄糖协同转运蛋白1的抑制剂 |
CN105461762A (zh) * | 2014-09-27 | 2016-04-06 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物及其在医药上的应用 |
WO2019134667A1 (zh) * | 2018-01-05 | 2019-07-11 | 南京明德新药研发股份有限公司 | 一种SGLTs抑制剂及其应用 |
Non-Patent Citations (1)
Title |
---|
DARDI, T. KOUVATSOS等: "SGLT2 inhibitors", 《BIOCHEMICAL PHARMACOLOGY》 * |
Also Published As
Publication number | Publication date |
---|---|
KR102471055B1 (ko) | 2022-11-28 |
CN114026079B (zh) | 2022-10-18 |
MX2022001044A (es) | 2022-04-06 |
KR20220031735A (ko) | 2022-03-11 |
CA3145678C (en) | 2022-08-23 |
EP4006017A4 (en) | 2023-09-06 |
WO2021018044A1 (zh) | 2021-02-04 |
AU2020320890B2 (en) | 2023-03-09 |
JP7227427B2 (ja) | 2023-02-21 |
CA3145678A1 (en) | 2021-02-04 |
US20220242898A1 (en) | 2022-08-04 |
EP4006017A1 (en) | 2022-06-01 |
JP2022533475A (ja) | 2022-07-22 |
AU2020320890A1 (en) | 2022-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN115698022B (zh) | 五元杂芳并咪唑类化合物及其应用 | |
EP4166142A1 (en) | Methyl-substituted benzobisoxazole compound and use thereof | |
CN114634510A (zh) | 咪唑并吡啶衍生物及其用途 | |
CN115594734B (zh) | 酮酰胺衍生物及其应用 | |
JP7086075B2 (ja) | Ccr2/ccr5受容体拮抗剤としてのビフェニル化合物 | |
CN113227051B (zh) | 用于视网膜疾病的化合物 | |
TW202317097A (zh) | 戊二醯亞胺類化合物與其應用 | |
CN114026079B (zh) | 一种sglt2/dpp4抑制剂及其应用 | |
JP7299408B2 (ja) | SGLTs/DPP4阻害剤およびその使用 | |
CN114096245B (zh) | 作为ccr2/ccr5拮抗剂的杂环烷基类化合物 | |
CN112218871B (zh) | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 | |
CN113825750B (zh) | 作为sglt1抑制剂的葡糖苷类衍生物及其应用 | |
CN112752749B (zh) | 作为pd-l1免疫调节剂的氟乙烯基苯甲酰胺基化合物 | |
CN113439080B (zh) | 作为pd-l1免疫调节剂的乙烯基吡啶甲酰胺基化合物 | |
CN115003672A (zh) | 喹啉并咪唑类化合物及其应用 | |
KR100913495B1 (ko) | 베타아미노기를 갖는 1,4-디아제펜 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 | |
CN114728904A (zh) | 用作选择性雄激素受体调节剂的双环类化合物 | |
CN114746400A (zh) | 用作选择性雄激素受体调节剂的化合物 | |
WO2022053028A1 (zh) | 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用 | |
CN116789636A (zh) | 双功能化合物及其制备方法、药物组合物和用途 | |
CN117136187A (zh) | 新型抗乙肝化合物 | |
CN116888099A (zh) | 含β-胺基酮的短肽化合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40062340 Country of ref document: HK |
|
GR01 | Patent grant | ||
GR01 | Patent grant |