MX2022001044A - Inhibidor de sglt2/dpp4 y su aplicacion. - Google Patents

Inhibidor de sglt2/dpp4 y su aplicacion.

Info

Publication number
MX2022001044A
MX2022001044A MX2022001044A MX2022001044A MX2022001044A MX 2022001044 A MX2022001044 A MX 2022001044A MX 2022001044 A MX2022001044 A MX 2022001044A MX 2022001044 A MX2022001044 A MX 2022001044A MX 2022001044 A MX2022001044 A MX 2022001044A
Authority
MX
Mexico
Prior art keywords
sglt2
application
dpp4 inhibitor
dpp4
dual inhibitors
Prior art date
Application number
MX2022001044A
Other languages
English (en)
Inventor
Yi Li
Qinghua Mao
Shuhui Chen
Chengde Wu
Tao Yu
Lu Gan
Original Assignee
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc filed Critical Medshine Discovery Inc
Publication of MX2022001044A publication Critical patent/MX2022001044A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compuestos como inhibidores duales de SGLT2/DPP4 y aplicación en la preparación de medicamentos como inhibidores duales de SGLT2/DPP4. Específicamente, están implicados un compuesto representado por la fórmula (I) y un isómero o una sal farmacéuticamente aceptable del mismo.
MX2022001044A 2019-07-26 2020-07-24 Inhibidor de sglt2/dpp4 y su aplicacion. MX2022001044A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201910683099 2019-07-26
CN202010119914 2020-02-26
CN202010572226 2020-06-22
PCT/CN2020/104521 WO2021018044A1 (zh) 2019-07-26 2020-07-24 一种sglt2/dpp4抑制剂及其应用

Publications (1)

Publication Number Publication Date
MX2022001044A true MX2022001044A (es) 2022-04-06

Family

ID=74228349

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001044A MX2022001044A (es) 2019-07-26 2020-07-24 Inhibidor de sglt2/dpp4 y su aplicacion.

Country Status (9)

Country Link
US (1) US20220242898A1 (es)
EP (1) EP4006017A4 (es)
JP (1) JP7227427B2 (es)
KR (1) KR102471055B1 (es)
CN (1) CN114026079B (es)
AU (1) AU2020320890B2 (es)
CA (1) CA3145678C (es)
MX (1) MX2022001044A (es)
WO (1) WO2021018044A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022160737A1 (zh) * 2021-01-26 2022-08-04 东宝紫星(杭州)生物医药有限公司 四氢吡喃环类化合物的晶型及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
CN103254119B (zh) * 2007-07-10 2016-07-06 莱西肯医药有限公司 钠-葡萄糖协同转运蛋白2的抑制剂及其用法
JO2870B1 (en) * 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
PL2395983T3 (pl) 2009-02-13 2020-09-07 Boehringer Ingelheim International Gmbh Kompozycja farmaceutyczna zawierająca inhibitor sglt2, inhibitor dpp-iv i ewentualnie dalszy środek przeciwcukrzycowy oraz jej zastosowania
WO2011070592A2 (en) * 2009-12-09 2011-06-16 Panacea Biotec Ltd. Novel sugar derivatives
MX365753B (es) * 2012-11-20 2019-06-12 Lexicon Pharmaceuticals Inc Inhibidores del contransportador 1 de sodio glucosa.
CN105461762B (zh) * 2014-09-27 2018-12-04 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其在医药上的应用
ES2941108T3 (es) * 2018-01-05 2023-05-16 Shandong Danhong Pharmaceutical Co Ltd Inhibidor de SGLTS y aplicación del mismo
AU2020323037B2 (en) * 2019-07-26 2023-08-03 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. SGLTS/DPP4 inhibitor and application thereof

Also Published As

Publication number Publication date
CN114026079A (zh) 2022-02-08
CN114026079B (zh) 2022-10-18
US20220242898A1 (en) 2022-08-04
AU2020320890B2 (en) 2023-03-09
EP4006017A1 (en) 2022-06-01
AU2020320890A1 (en) 2022-03-17
WO2021018044A1 (zh) 2021-02-04
CA3145678C (en) 2022-08-23
JP2022533475A (ja) 2022-07-22
KR102471055B1 (ko) 2022-11-28
CA3145678A1 (en) 2021-02-04
EP4006017A4 (en) 2023-09-06
KR20220031735A (ko) 2022-03-11
JP7227427B2 (ja) 2023-02-21

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