CN105461762A - 吡喃葡萄糖基衍生物及其在医药上的应用 - Google Patents
吡喃葡萄糖基衍生物及其在医药上的应用 Download PDFInfo
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- CN105461762A CN105461762A CN201510621933.7A CN201510621933A CN105461762A CN 105461762 A CN105461762 A CN 105461762A CN 201510621933 A CN201510621933 A CN 201510621933A CN 105461762 A CN105461762 A CN 105461762A
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- ethyl
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
多反应检测扫描 | 490.2→383.1 |
碎裂电压 | 230V |
毛细管电压 | 55V |
干燥器温度 | 350℃ |
雾化器 | 40psi |
干燥器流速 | 10L/min |
时间 | 流动相B的梯度 |
0.5min | 5% |
1.0min | 95% |
2.2min | 95% |
2.3min | 5% |
5.0min | 终止 |
实施例编号 | IC50(SGLT-2)/nM | IC50(SGLT-1)/nM |
实施例2 | 3.05 | 170 |
实施例编号 | IC50(SGLT-2)/nM | IC50(SGLT-1)/nM |
实施例3 | 2.82 | 380 |
实施例5 | 2.75 | 230 |
实施例7 | 3.52 | 150 |
实施例9 | 13.8 | NT |
实施例10 | 12.4 | NT |
实施例11 | 4.33 | NT |
实施例13 | 3.47 | 470 |
实施例14 | 10.7 | NT |
实施例16 | 4.80 | 218 |
实施例17 | 3.87 | 388 |
实施例18 | 8.00 | 151 |
实施例19 | 4.45 | 128 |
实施例20 | 5.65 | 382 |
实施例21 | 2.03 | 106 |
实施例22 | 3.17 | 183 |
实施例24 | 6.19 | 291 |
实施例25 | 3.63 | 268 |
实施例27 | 5.2 | 96.8 |
实施例编号 | 降糖率(%) |
实施例2 | 44.20 |
实施例6 | 58.01 |
实施例编号 | 降糖率(%) |
实施例8 | 49.14 |
实施例15 | 49.24 |
实施例16 | 44.76 |
Claims (16)
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