MX354242B - Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. - Google Patents
Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.Info
- Publication number
- MX354242B MX354242B MX2014005121A MX2014005121A MX354242B MX 354242 B MX354242 B MX 354242B MX 2014005121 A MX2014005121 A MX 2014005121A MX 2014005121 A MX2014005121 A MX 2014005121A MX 354242 B MX354242 B MX 354242B
- Authority
- MX
- Mexico
- Prior art keywords
- pediatric
- treatment
- bile acid
- cholestatic liver
- liver diseases
- Prior art date
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
En el presente documento se proporcionan formas de dosificación pediátricas para su uso en el tratamiento de una enfermedad hepática colestásica pediátrica mediante la administración no sistémica a un individuo que lo necesita de una cantidad terapéuticamente eficaz de la forma de dosificación pediátrica que comprende un inhibidor del transportador de ácidos biliares dependiente de sodio apical (ASBTI) o una sal farmacéuticamente aceptable del mismo. También se proporciona dicha forma de dosificación pediátrica para su uso en el tratamiento de una enfermedad hepática pediátrica, para su uso en la disminución de los niveles de ácidos biliares séricos o ácidos biliares hepáticos, para su uso en el tratamiento de prurito, para su uso en la reducción de enzimas hepáticas o bilirrubina que comprende la administración no sistémica a un individuo que lo necesita de una cantidad terapéuticamente eficaz de una formulación pediátrica que comprende un ASBTI o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161553094P | 2011-10-28 | 2011-10-28 | |
US201261607503P | 2012-03-06 | 2012-03-06 | |
US201261607487P | 2012-03-06 | 2012-03-06 | |
PCT/US2012/062284 WO2013063512A1 (en) | 2011-10-28 | 2012-10-26 | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014005121A MX2014005121A (es) | 2014-10-17 |
MX354242B true MX354242B (es) | 2018-02-20 |
Family
ID=48168608
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018002094A MX369466B (es) | 2011-10-28 | 2012-10-26 | Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
MX2014005121A MX354242B (es) | 2011-10-28 | 2012-10-26 | Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
MX2019013263A MX2019013263A (es) | 2011-10-28 | 2014-04-28 | Inhibidores de la recirculacion de acidos biliares para el tratamiento de enfermedades hepaticas colestasicas pediatricas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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MX2018002094A MX369466B (es) | 2011-10-28 | 2012-10-26 | Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
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JP (4) | JP6217938B2 (es) |
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