EA201891154A1 - Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей - Google Patents

Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей

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EA201891154A1
EA201891154A1 EA201891154A EA201891154A EA201891154A1 EA 201891154 A1 EA201891154 A1 EA 201891154A1 EA 201891154 A EA201891154 A EA 201891154A EA 201891154 A EA201891154 A EA 201891154A EA 201891154 A1 EA201891154 A1 EA 201891154A1
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Eurasian Patent Office
Prior art keywords
children
liver
treatment
inhibitors
acid recycling
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EA201891154A
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English (en)
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Бронислава Гедулин
Майкл Грей
Нейл О'Доннел
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ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи
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Publication of EA201891154A1 publication Critical patent/EA201891154A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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Abstract

Предложены детские лекарственные формы для применения в лечении холестатических заболеваний печени у детей путем несистемного введения пациенту терапевтически эффективного количества детской лекарственной формы, содержащей ингибитор апикального натрийзависимого транспортера желчных кислот (ASBTI) или его терапевтически приемлемую соль. Также предложены указанные детские лекарственные формы для применения в лечении заболеваний печени у детей, для снижения содержания желчных кислот в сыворотке или печени, лечения зуда, уменьшения содержания ферментов печени или билирубина, включающие несистемное введение пациенту терапевтически эффективного количества детского препарата, содержащего ASBTI или его терапевтически приемлемую соль.
EA201891154A 2011-10-28 2012-10-26 Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей EA201891154A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607503P 2012-03-06 2012-03-06
US201261607487P 2012-03-06 2012-03-06

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EA201891154A1 true EA201891154A1 (ru) 2019-02-28

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EA201490876A EA030839B1 (ru) 2011-10-28 2012-10-26 Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей

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