FR2698873B1 - Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. - Google Patents
Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.Info
- Publication number
- FR2698873B1 FR2698873B1 FR9214720A FR9214720A FR2698873B1 FR 2698873 B1 FR2698873 B1 FR 2698873B1 FR 9214720 A FR9214720 A FR 9214720A FR 9214720 A FR9214720 A FR 9214720A FR 2698873 B1 FR2698873 B1 FR 2698873B1
- Authority
- FR
- France
- Prior art keywords
- pct
- group
- activators
- potassium channels
- benzothiepins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Priority Applications (30)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9214720A FR2698873B1 (fr) | 1992-12-07 | 1992-12-07 | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
SI9300632A SI9300632A (en) | 1992-12-07 | 1993-12-03 | Benzocycloheptenes, benzoxepines and benzothiepines |
LTIP1525A LT3167B (en) | 1992-12-07 | 1993-12-03 | Benzocycloheptenes,benzoxepines and benzothiepines |
IL10789193A IL107891A0 (en) | 1992-12-07 | 1993-12-06 | Benzocycloheptenes, benzoxepines and benzothiepines |
CN93120135A CN1050127C (zh) | 1992-12-07 | 1993-12-06 | 苯并环庚烯和苯并氧杂䓬其制备方法和含有它们的药物组合物 |
ZA939127A ZA939127B (en) | 1992-12-07 | 1993-12-06 | Benzocycloheptenes benzoxepines and benzothiepines |
DE69324001T DE69324001T2 (de) | 1992-12-07 | 1993-12-07 | Benzocycloheptine, benzoxepine und benzothiepine |
SK939-94A SK93994A3 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines and method their producing |
CA002129642A CA2129642A1 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
DK94902708T DK0626954T3 (da) | 1992-12-07 | 1993-12-07 | Benzocycloheptener, benzoxepiner og benzothiepiner |
TW082110417A TW276255B (fr) | 1992-12-07 | 1993-12-07 | |
CZ941848A CZ184894A3 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines and process for preparing thereof |
JP6513771A JPH07503977A (ja) | 1992-12-07 | 1993-12-07 | ベンゾシクロヘプテン,ベンゾキセピンおよびベンゾチエピン |
AT94902708T ATE177742T1 (de) | 1992-12-07 | 1993-12-07 | Benzocycloheptine, benzoxepine und benzothiepine |
PCT/EP1993/003445 WO1994013658A2 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
KR1019940702708A KR100236810B1 (ko) | 1992-12-07 | 1993-12-07 | 벤조사이클로헵텐 |
US08/284,454 US5602152A (en) | 1992-12-07 | 1993-12-07 | Benzoxepines |
RU94040853A RU2127268C1 (ru) | 1992-12-07 | 1993-12-07 | Производные бензоциклогептена или бензоксепина, способ их получения, промежуточные соединения и фармацевтическая композиция |
RO94-01321A RO113040B1 (ro) | 1992-12-07 | 1993-12-07 | Derivati heterociclici de benzocicloheptene, benzoxepine sau benzotiepine, procedeu pentru prepararea acestora, compusi intermediari si compozitie farmaceutica |
AU56975/94A AU680856B2 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines |
PL93304719A PL174246B1 (pl) | 1992-12-07 | 1993-12-07 | Nowe związki, pochodne benzocykloheptenu, benzoksepiny i benzotiepiny |
NZ258896A NZ258896A (en) | 1992-12-07 | 1993-12-07 | Heterocyclic substituted benzoxepine and benzocycloheptene derivatives; pharmaceutical compositions thereof |
ES94902708T ES2132373T3 (es) | 1992-12-07 | 1993-12-07 | Benzocicloheptenos, benzoxepinas y benzotiepinas. |
HU9402302A HUT67852A (en) | 1992-12-07 | 1993-12-07 | New benzocycloheptenes, and benzoxepines, pharmaceutical compositions containing them and process for producing them |
EP94902708A EP0626954B1 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
LVP-94-154A LV10451B (en) | 1992-12-07 | 1994-08-05 | Benzocycloheptenes, benzoxepines and benzothiepines and methods for preparation thereof |
FI943646A FI943646A (fi) | 1992-12-07 | 1994-08-05 | Bentsosyklohepteenejä, bentsoksepiinejä bentsotiepiinejä |
NO942914A NO942914L (no) | 1992-12-07 | 1994-08-05 | Benzosykloheptener, benzoksepiner og benzotiepiner |
US08/460,866 US5652252A (en) | 1992-07-12 | 1995-06-05 | Benzocycloheptenes |
GR990401589T GR3030514T3 (en) | 1992-12-07 | 1999-06-15 | Benzocycloheptenes, benzoxepines and benzothiepines. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9214720A FR2698873B1 (fr) | 1992-12-07 | 1992-12-07 | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2698873A1 FR2698873A1 (fr) | 1994-06-10 |
FR2698873B1 true FR2698873B1 (fr) | 1995-02-24 |
Family
ID=9436308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9214720A Expired - Fee Related FR2698873B1 (fr) | 1992-07-12 | 1992-12-07 | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
Country Status (29)
Country | Link |
---|---|
US (2) | US5602152A (fr) |
EP (1) | EP0626954B1 (fr) |
JP (1) | JPH07503977A (fr) |
KR (1) | KR100236810B1 (fr) |
CN (1) | CN1050127C (fr) |
AT (1) | ATE177742T1 (fr) |
AU (1) | AU680856B2 (fr) |
CA (1) | CA2129642A1 (fr) |
CZ (1) | CZ184894A3 (fr) |
DE (1) | DE69324001T2 (fr) |
DK (1) | DK0626954T3 (fr) |
ES (1) | ES2132373T3 (fr) |
FI (1) | FI943646A (fr) |
FR (1) | FR2698873B1 (fr) |
GR (1) | GR3030514T3 (fr) |
HU (1) | HUT67852A (fr) |
IL (1) | IL107891A0 (fr) |
LT (1) | LT3167B (fr) |
LV (1) | LV10451B (fr) |
NO (1) | NO942914L (fr) |
NZ (1) | NZ258896A (fr) |
PL (1) | PL174246B1 (fr) |
RO (1) | RO113040B1 (fr) |
RU (1) | RU2127268C1 (fr) |
SI (1) | SI9300632A (fr) |
SK (1) | SK93994A3 (fr) |
TW (1) | TW276255B (fr) |
WO (1) | WO1994013658A2 (fr) |
ZA (1) | ZA939127B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
JP3304093B2 (ja) * | 1994-09-13 | 2002-07-22 | モンサント カンパニー | 回腸の胆汁酸輸送及びタウロコール酸塩吸収の阻害活性を有する新規ベンゾチエピン類 |
US5952326A (en) * | 1997-12-10 | 1999-09-14 | Pfizer Inc. | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases |
US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
BR9916564A (pt) * | 1998-12-23 | 2002-01-29 | Searle Llc | Combinações para indicações cardiovasculares |
EP1340510A1 (fr) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinaisons d'inhibiteurs de la protéine de transfert de l'ester de cholestéryle utilisées dans le cadre de troubles cardio-vasculaires |
EA004231B1 (ru) * | 1998-12-23 | 2004-02-26 | Джи.Ди.Сирл Ллс | Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний |
ES2189529T3 (es) * | 1998-12-23 | 2003-07-01 | Searle Llc | Combinaciones de inhiidores para el transporte de acidos biliares en el ileon y agentes complejantes para indicaciones cardiovasculares. |
HUP0201972A3 (en) * | 1998-12-23 | 2005-06-28 | G D Searle Llc Chicago | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
BR9916565A (pt) * | 1998-12-23 | 2002-01-29 | Searle Llc | Combinações de inibidores do transporte ácido da bile ileal e derivados do ácido fìbrico para indicações cardiovasculares |
WO2000038722A1 (fr) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'INHIBITEURS DE LA HMG CoA-REDUCTASE UTILISEES DANS LE CADRE DE TROUBLES CARDIO-VASCULAIRES |
PT1140184E (pt) * | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares |
AU2001240115A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
AU2001247331A1 (en) * | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
WO2003040127A1 (fr) * | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Composes benzothiepine mono- et di-fluores en tant qu'inhibiteurs du transport d'acides biliaires a co-dependance sodique apicale (asbt) et de reprise de taurocholate |
CA2471639A1 (fr) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate |
BR112014010223B8 (pt) | 2011-10-28 | 2021-02-23 | Lumena Pharmaceuticals Llc | uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica |
WO2013152170A1 (fr) | 2012-04-04 | 2013-10-10 | Catylix, Inc. | Modulateurs sélectifs de récepteur d'androgène |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
US3444176A (en) * | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
AU8402275A (en) * | 1974-08-26 | 1977-02-17 | Takeda Chemical Industries Ltd | Benzocycloheptene derivatives |
US4066663A (en) * | 1976-07-01 | 1978-01-03 | Syntex (U.S.A.) Inc. | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives |
GB2107706A (en) | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
US4416687A (en) * | 1982-02-01 | 1983-11-22 | Monsanto Company | 3,5-Bis (trifluoromethyl)phenoxy carboxylic acids and derivatives thereof |
NZ207110A (en) * | 1983-02-15 | 1986-05-09 | Merrell Dow Pharma | (4a,11b)-3,4,4a,5,6,11b-hexahydro-2h-(1)benzoxepino(5,4,b)-1,4-oxazine derivatives and pharmaceutical compositions |
AU597671B2 (en) * | 1986-06-20 | 1990-06-07 | Suntory Limited | 2-Phenylbenzoxepin derivative |
DE3726261A1 (de) | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
GB8812765D0 (en) * | 1988-05-28 | 1988-06-29 | Beecham Group Plc | Novel compounds |
DE3831697A1 (de) * | 1988-09-17 | 1990-03-22 | Hoechst Ag | 2,3,4,5-tetrahydro-1-benzoxepine, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
DE3922392A1 (de) * | 1989-07-07 | 1991-01-17 | Merck Patent Gmbh | Chromanderivate |
JP3018386B2 (ja) * | 1990-01-24 | 2000-03-13 | 吉富製薬株式会社 | 光学活性なベンゾチエピノピリダジン化合物の製造法 |
-
1992
- 1992-12-07 FR FR9214720A patent/FR2698873B1/fr not_active Expired - Fee Related
-
1993
- 1993-12-03 LT LTIP1525A patent/LT3167B/lt not_active IP Right Cessation
- 1993-12-03 SI SI9300632A patent/SI9300632A/sl unknown
- 1993-12-06 IL IL10789193A patent/IL107891A0/xx unknown
- 1993-12-06 ZA ZA939127A patent/ZA939127B/xx unknown
- 1993-12-06 CN CN93120135A patent/CN1050127C/zh not_active Expired - Fee Related
- 1993-12-07 ES ES94902708T patent/ES2132373T3/es not_active Expired - Lifetime
- 1993-12-07 AT AT94902708T patent/ATE177742T1/de not_active IP Right Cessation
- 1993-12-07 PL PL93304719A patent/PL174246B1/pl unknown
- 1993-12-07 NZ NZ258896A patent/NZ258896A/en unknown
- 1993-12-07 US US08/284,454 patent/US5602152A/en not_active Expired - Fee Related
- 1993-12-07 CA CA002129642A patent/CA2129642A1/fr not_active Abandoned
- 1993-12-07 RU RU94040853A patent/RU2127268C1/ru active
- 1993-12-07 EP EP94902708A patent/EP0626954B1/fr not_active Expired - Lifetime
- 1993-12-07 HU HU9402302A patent/HUT67852A/hu unknown
- 1993-12-07 JP JP6513771A patent/JPH07503977A/ja active Pending
- 1993-12-07 AU AU56975/94A patent/AU680856B2/en not_active Ceased
- 1993-12-07 DE DE69324001T patent/DE69324001T2/de not_active Expired - Fee Related
- 1993-12-07 RO RO94-01321A patent/RO113040B1/ro unknown
- 1993-12-07 WO PCT/EP1993/003445 patent/WO1994013658A2/fr not_active Application Discontinuation
- 1993-12-07 KR KR1019940702708A patent/KR100236810B1/ko not_active IP Right Cessation
- 1993-12-07 DK DK94902708T patent/DK0626954T3/da active
- 1993-12-07 CZ CZ941848A patent/CZ184894A3/cs unknown
- 1993-12-07 SK SK939-94A patent/SK93994A3/sk unknown
- 1993-12-07 TW TW082110417A patent/TW276255B/zh active
-
1994
- 1994-08-05 NO NO942914A patent/NO942914L/no unknown
- 1994-08-05 LV LVP-94-154A patent/LV10451B/en unknown
- 1994-08-05 FI FI943646A patent/FI943646A/fi unknown
-
1995
- 1995-06-05 US US08/460,866 patent/US5652252A/en not_active Expired - Fee Related
-
1999
- 1999-06-15 GR GR990401589T patent/GR3030514T3/el unknown
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