BR112014010223B8 - uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica - Google Patents

uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica

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Publication number
BR112014010223B8
BR112014010223B8 BR112014010223A BR112014010223A BR112014010223B8 BR 112014010223 B8 BR112014010223 B8 BR 112014010223B8 BR 112014010223 A BR112014010223 A BR 112014010223A BR 112014010223 A BR112014010223 A BR 112014010223A BR 112014010223 B8 BR112014010223 B8 BR 112014010223B8
Authority
BR
Brazil
Prior art keywords
pediatric
treatment
bile acid
dosage form
pediatric dosage
Prior art date
Application number
BR112014010223A
Other languages
English (en)
Other versions
BR112014010223A2 (pt
BR112014010223B1 (pt
BR112014010223A8 (pt
Inventor
Gedulin Bronislava
Grey Michael
O'donnell Niall
Original Assignee
Lumena Pharmaceuticals Llc
Lumena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48168608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014010223(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumena Pharmaceuticals Llc, Lumena Pharmaceuticals Inc filed Critical Lumena Pharmaceuticals Llc
Publication of BR112014010223A2 publication Critical patent/BR112014010223A2/pt
Publication of BR112014010223A8 publication Critical patent/BR112014010223A8/pt
Publication of BR112014010223B1 publication Critical patent/BR112014010223B1/pt
Publication of BR112014010223B8 publication Critical patent/BR112014010223B8/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

inibidores de reciclagem de ácido de bílis para o tratamento de doenças hepáticas colestáticas pediatras.são aqui fornecidas formas de dosagem pediátricas para o uso no tratamento de uma doença hepática colestática pediatra por administrar não sistematicamente a um indivíduo, na necessidade disso, uma quantidade terapeuticamente eficaz da forma de dosagem pediatra que compreende um inibidor de transporte de ácido biliar dependente de sódio apical (asbti) ou um sal farmaceuticamente aceitável disso. são também fornecidas referidas formas de dosagem pediatra para o uso no tratamento de uma doença hepática pediatra, para o uso em diminuição dos níveis de ácidos biliares ou de ácidos biliares hepáticos do soro, para o uso no tratamento do prurido, para o uso em redução das enzimas do fígado ou a bilirrubina que compreendem a administração, não sistematicamente, a um indivíduo na necessidade disso de uma quantidade terapeuticamente eficaz de uma formulação pediatra que compreende um asbti ou um sal farmaceuticamente aceitável disso.
BR112014010223A 2011-10-28 2012-10-26 uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica BR112014010223B8 (pt)

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US201161553094P 2011-10-28 2011-10-28
US61/553.094 2011-10-28
US201261607503P 2012-03-06 2012-03-06
US201261607487P 2012-03-06 2012-03-06
US61/607.503 2012-03-06
US61/607.487 2012-03-06
PCT/US2012/062284 WO2013063512A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

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