RU2314126C2 - Комбинации ингибитора (ингибиторов) всасывания стерина с модификатором (модификаторами) крови, предназначенные для лечения патологических состояний сосудов - Google Patents

Комбинации ингибитора (ингибиторов) всасывания стерина с модификатором (модификаторами) крови, предназначенные для лечения патологических состояний сосудов Download PDF

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RU2314126C2
RU2314126C2 RU2003126185/15A RU2003126185A RU2314126C2 RU 2314126 C2 RU2314126 C2 RU 2314126C2 RU 2003126185/15 A RU2003126185/15 A RU 2003126185/15A RU 2003126185 A RU2003126185 A RU 2003126185A RU 2314126 C2 RU2314126 C2 RU 2314126C2
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combination
treatment
mammal
sterol
sterol absorption
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Тедди КОСОГЛОУ (US)
Тедди КОСОГЛОУ
Радь рд Джозеф РЕСС (US)
Радьярд Джозеф РЕСС
Джон СТРОУНИ (US)
Джон СТРОУНИ
Энрико П. ВЕЛТРИ (US)
Энрико П. ВЕЛТРИ
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Шеринг Корпорейшн
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Abstract

Изобретение относится к области медицины и фармацевтики и касается комбинации для лечения или предупреждения сосудистых патологических состояний, ожирения, диабета или снижения концентрации стерина в плазме млекопитающего, включающей ингибитор всасывания стерина формулы (II) и модификатор крови, представляющий собой ацетилсалициловую кислоту. Изобретение обеспечивает повышение эффективности лечения. 2 н. и 4 з.п. ф-лы.

Description

Текст описания приведен в факсимильном виде.
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Claims (4)

1. Комбинация, предназначенная для лечения или предупреждения сосудистых патологических состояний, ожирения, диабета или снижения концентрации стерина в плазме млекопитающего, включающая
(а) ингибитор всасывания стерина, представляющий собой соединение формулы (II)
Figure 00000100
или его фармацевтически приемлемые соли или сольваты, и
(b) модификатор крови, представляющий собой ацетилсалициловую кислоту,
причем компоненты (а) и (b) взяты в терапевтически эффективном количестве.
2. Способ лечения или предупреждения сосудистых патологических состояний, диабета, ожирения или снижения концентрации стерина в плазме млекопитающего, включающий стадию введения млекопитающему, нуждающемуся в таком лечении, комбинации по п.1 в эффективном количестве.
3. Способ по п.2, в котором модификатор крови вводят млекопитающему в количестве, составляющем от около 1 до около 1000 мг модификатора крови в сутки.
4. Способ по п.2, в котором ингибитор всасывания стерина вводят млекопитающему в количестве, составляющем от около 0,1 до около 1000 мг ингибитора всасывания стерина в сутки.
RU2003126185/15A 2001-01-26 2002-01-25 Комбинации ингибитора (ингибиторов) всасывания стерина с модификатором (модификаторами) крови, предназначенные для лечения патологических состояний сосудов RU2314126C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US60/264,369 2001-01-25
US26460001P 2001-01-26 2001-01-26
US26439601P 2001-01-26 2001-01-26
US26427501P 2001-01-26 2001-01-26
US60/264,275 2001-01-26
US60/264,600 2001-01-26
US32412301P 2001-09-21 2001-09-21
US60/324,123 2001-09-21
PCT/US2002/002013 WO2002058734A2 (en) 2001-01-26 2002-01-25 Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions

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RU2003126185A RU2003126185A (ru) 2005-03-10
RU2314126C2 true RU2314126C2 (ru) 2008-01-10

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