AU2002231688A1 - Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use - Google Patents

Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Info

Publication number
AU2002231688A1
AU2002231688A1 AU2002231688A AU3168802A AU2002231688A1 AU 2002231688 A1 AU2002231688 A1 AU 2002231688A1 AU 2002231688 A AU2002231688 A AU 2002231688A AU 3168802 A AU3168802 A AU 3168802A AU 2002231688 A1 AU2002231688 A1 AU 2002231688A1
Authority
AU
Australia
Prior art keywords
compounds
production
medicaments containing
azetidinone derivatives
diphenyl azetidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002231688A
Inventor
Stefanie Flohr
Wendelin Frick
Heiner Glombik
Hubert Heuer
Gerhard Jaehne
Werner Kramer
Andreas Lindenschmidt
Hans-Ludwig Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10064402A external-priority patent/DE10064402A1/en
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU2002231688A1 publication Critical patent/AU2002231688A1/en
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH Request for Assignment Assignors: AVENTIS PHARMA DEUTSCHLAND GMBH
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
AU2002231688A 2000-12-21 2001-12-11 Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use Abandoned AU2002231688A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10064402 2000-12-21
DE10064402A DE10064402A1 (en) 2000-12-21 2000-12-21 New diphenyl-azetidinone derivatives useful for the treatment of hyperlipidemia, arteriosclerosis and hypercholesterolemia
DE10154518 2001-11-07
DE10154518 2001-11-07
PCT/EP2001/014533 WO2002050060A1 (en) 2000-12-21 2001-12-11 Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Publications (1)

Publication Number Publication Date
AU2002231688A1 true AU2002231688A1 (en) 2002-07-01

Family

ID=26008044

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002231688A Abandoned AU2002231688A1 (en) 2000-12-21 2001-12-11 Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Country Status (24)

Country Link
US (1) US6703386B2 (en)
EP (1) EP1345924B1 (en)
JP (1) JP2004516289A (en)
KR (1) KR20030063462A (en)
CN (1) CN1221546C (en)
AR (1) AR033600A1 (en)
AT (1) ATE338039T1 (en)
AU (1) AU2002231688A1 (en)
BR (1) BR0116322A (en)
CA (1) CA2431995A1 (en)
CZ (1) CZ20031733A3 (en)
DE (1) DE50110906D1 (en)
EE (1) EE200300238A (en)
HK (1) HK1060119A1 (en)
HR (1) HRP20030501A2 (en)
HU (1) HUP0401073A2 (en)
IL (1) IL156548A0 (en)
MX (1) MXPA03005019A (en)
NO (1) NO20032735L (en)
NZ (1) NZ526594A (en)
PL (1) PL362512A1 (en)
SK (1) SK7782003A3 (en)
WO (1) WO2002050060A1 (en)
YU (1) YU47803A (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2434488A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
ES2274013T3 (en) * 2001-01-26 2007-05-16 Schering Corporation RECEIVER ACTIVATOR (S) COMBINATIONS ACTIVATED BY THE PROOFISER OF PEROXISOMES (PPAR) AND INHIBITOR (S) M OF THE ABSORPTION OF STELORS AND TREATMENTS FOR VASCULAR DISORDERS.
BR0206644A (en) * 2001-01-26 2004-02-25 Schering Corp Sterol absorption inhibitor (s) combinations with cardiovascular agent (s) for the treatment of vascular conditions
AR032403A1 (en) * 2001-01-26 2003-11-05 Schering Corp INHIBITOR COMBINATIONS (ES) OF STEROL ABSORPTION WITH BLOOD MODIFIER (ES) TO TREAT VASCULAR TABLES
ES2287250T3 (en) * 2001-01-26 2007-12-16 Schering Corporation COMBINATIONS OF SEQUENCER (S) OF BILIARY ACIDS AND INHIBITOR (S) OF THE ABSORPTION OF STEROLS AND TREATMENTS FOR VASCULAR INDICATIONS.
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
EP1429756B1 (en) * 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7176193B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
DE10227508A1 (en) * 2002-06-19 2004-01-08 Aventis Pharma Deutschland Gmbh Acid group-substituted diphenylazetidinones, processes for their preparation, pharmaceutical compositions containing them and their use
DE10227507A1 (en) * 2002-06-19 2004-01-08 Aventis Pharma Deutschland Gmbh Cationically substituted diphenylazetidinones, processes for their preparation, medicaments containing these compounds and their use
US7671047B2 (en) 2002-06-19 2010-03-02 Sanofi-Aventis Deutschland Gmbh Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
DE10303900A1 (en) * 2003-01-31 2004-08-12 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Synergistic cholesterol lowering composition, useful as medicament or food or feed additive, comprising dietary fiber component and ahypocholesterolemic agent, e.g. statin
CN1756756A (en) 2003-03-07 2006-04-05 先灵公司 Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
ES2311806T3 (en) 2003-03-07 2009-02-16 Schering Corporation AZETIDINONA COMPOSITE SUBSTITUTED, FORNULATIONS AND USES OF THE SAME FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA.
WO2005021497A2 (en) * 2003-08-28 2005-03-10 Microbia, Inc. Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
ATE485267T1 (en) * 2003-12-23 2010-11-15 Astrazeneca Ab DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
DE102004024454A1 (en) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
JP2008514718A (en) * 2004-09-29 2008-05-08 シェーリング コーポレイション Combinations of substituted azetidonones and CB1 antagonists
AU2005311930B9 (en) 2004-12-03 2009-09-10 Merck Sharp & Dohme Corp. Substituted piperazines as CB1 antagonists
WO2007001975A1 (en) * 2005-06-20 2007-01-04 Schering Corporation Piperidine derivatives useful as histamine h3 antagonists
SA06270191B1 (en) 2005-06-22 2010-03-29 استرازينيكا ايه بي Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
PE20071320A1 (en) * 2006-01-18 2007-12-29 Schering Corp CANNABINOID RECEPTOR MODULATORS
AR060623A1 (en) 2006-04-27 2008-07-02 Astrazeneca Ab COMPOUNDS DERIVED FROM 2-AZETIDINONE AND A PREPARATION METHOD
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
CA2694264A1 (en) * 2007-06-28 2009-01-08 Intervet International B.V. Substituted piperazines as cb1 antagonists
RU2010102478A (en) * 2007-06-28 2011-08-10 Интэрвэт Интэрнэшнл Б.Ф. (NL) SUBSTITUTED PIPERASINS AS CB1 ANTAGONISTS
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
DE102007063671A1 (en) 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh New crystalline diphenylazetidinone hydrates, medicaments containing these compounds and their use
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
EP2403848A1 (en) 2009-03-06 2012-01-11 Lipideon Biotechnology AG Pharmaceutical hypocholesterolemic compositions
CN101993403B (en) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 Azetidinone compound and medical applications thereof
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
WO2011157827A1 (en) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0766667A1 (en) * 1994-06-20 1997-04-09 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
EP0876379A1 (en) 1996-01-17 1998-11-11 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
ES2283025T3 (en) 1996-08-30 2007-10-16 Novo Nordisk A/S DERIVATIVES OF GLP-1.1.
DE59811528D1 (en) * 1997-04-04 2004-07-15 Aventis Pharma Gmbh Hypolipidemic propanolamine derivatives
DE19845402B4 (en) * 1998-10-02 2005-04-07 Aventis Pharma Deutschland Gmbh Heterocyclic substituted propanolamine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
BR9810592A (en) 1997-07-16 2000-09-12 Novo Nordisk As Compound, processes for preparing a compound, for treating or preventing diseases of the endocrine system and for the manufacture of a drug, pharmaceutical composition, and, use of a compound
DE19845406C2 (en) * 1998-10-02 2001-10-18 Aventis Pharma Gmbh Substituted 1,3-diaryl-2-pyridin-2-yl-3- (pyridin-2-ylamino) propanol derivatives, process for their preparation, medicaments containing these compounds and their use

Also Published As

Publication number Publication date
ATE338039T1 (en) 2006-09-15
AR033600A1 (en) 2003-12-26
HRP20030501A2 (en) 2005-04-30
HUP0401073A2 (en) 2004-09-28
IL156548A0 (en) 2004-01-04
WO2002050060A1 (en) 2002-06-27
NZ526594A (en) 2004-08-27
CN1481378A (en) 2004-03-10
KR20030063462A (en) 2003-07-28
SK7782003A3 (en) 2003-12-02
BR0116322A (en) 2003-10-14
HK1060119A1 (en) 2004-07-30
PL362512A1 (en) 2004-11-02
CZ20031733A3 (en) 2003-09-17
DE50110906D1 (en) 2006-10-12
JP2004516289A (en) 2004-06-03
MXPA03005019A (en) 2003-09-25
EP1345924A1 (en) 2003-09-24
NO20032735D0 (en) 2003-06-16
NO20032735L (en) 2003-08-06
EP1345924B1 (en) 2006-08-30
US6703386B2 (en) 2004-03-09
CN1221546C (en) 2005-10-05
CA2431995A1 (en) 2002-06-27
YU47803A (en) 2006-05-25
EE200300238A (en) 2003-08-15
US20020128253A1 (en) 2002-09-12

Similar Documents

Publication Publication Date Title
AU2002219173A1 (en) Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
AU2002231688A1 (en) Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
HK1059936A1 (en) Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
AU2002219174A1 (en) Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof
AU2001295481A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
AU2001287694A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
AU2001284021A1 (en) Quinazoline derivatives, medicaments containing these compounds, their use, and methods for the production thereof
ZA200102588B (en) Aryl-substituted propanolamine derivatives, methods for their production, medicaments containing said compounds and their use.
AU2003257465A1 (en) Substituted diaryl heterocycles, method for the production and use thereof as medicaments
HUS1400005I1 (en) Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof
MXPA03001483A (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof.
HK1081965A1 (en) Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
HK1054026A1 (en) Substituted piperidines, medicaments containing these compounds, and methods for the production thereof.
AU2001289814A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
AU2003226806A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and method for the production thereof
HUP0204360A3 (en) Substituted norbornylamino derivatives, method for the production thereof, use thereof as a medicament and medicaments containing said compounds
AU3825700A (en) Pyrido-thieno-diazepines, method for the production thereof and pharmaceutical compositions containing said pyrido-thieno-diazepines
AU7517800A (en) 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments
AU2001231676A1 (en) Substituted phenylamidines medicaments containing said compounds and method for production thereof
AU2002333449A1 (en) C2-substituted indane-1-ols and their derivatives, method for their production and their use as medicaments
AU2002336085A1 (en) C2-substituted Indane-1-ones and their derivatives, method for their production and their use as medicaments
AU2002336983A1 (en) C2-disubstituted Indane-1-ones and their derivatives, method for their production and their use as medicaments
AU2002339519A1 (en) Coniosulphides and their derivatives, method for their production and use as medicaments
ZA200110351B (en) Bycyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof.
AU2002321016A1 (en) Novel 1-amidomethylcarbonyl-piperidine derivatives, method and intermediate products for the production thereof and medicament containing said compounds