FR2403078A1 - Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic - Google Patents

Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic

Info

Publication number
FR2403078A1
FR2403078A1 FR7728193A FR7728193A FR2403078A1 FR 2403078 A1 FR2403078 A1 FR 2403078A1 FR 7728193 A FR7728193 A FR 7728193A FR 7728193 A FR7728193 A FR 7728193A FR 2403078 A1 FR2403078 A1 FR 2403078A1
Authority
FR
France
Prior art keywords
solvent
substances
cosmetic
pharmaceutical
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7728193A
Other languages
English (en)
Other versions
FR2403078B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Priority to FR7728193A priority Critical patent/FR2403078A1/fr
Priority to US05/875,542 priority patent/US4178695A/en
Priority to IE1341/78A priority patent/IE47020B1/en
Priority to SE7808007A priority patent/SE444645B/sv
Priority to DK333678A priority patent/DK154528C/da
Priority to GB7832497A priority patent/GB2004182B/en
Priority to JP10903678A priority patent/JPS5495720A/ja
Priority to CA311,409A priority patent/CA1097209A/fr
Priority to IT51099/78A priority patent/IT1106901B/it
Priority to DE19782840461 priority patent/DE2840461A1/de
Priority to CH973478A priority patent/CH633445A5/fr
Priority to BE190539A priority patent/BE870548A/fr
Priority to ES473459A priority patent/ES473459A1/es
Priority to LU80251A priority patent/LU80251A1/fr
Priority to NLAANVRAGE7809522,A priority patent/NL186675C/xx
Publication of FR2403078A1 publication Critical patent/FR2403078A1/fr
Application granted granted Critical
Publication of FR2403078B1 publication Critical patent/FR2403078B1/fr
Granted legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0283—Matrix particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/652—The particulate/core comprising organic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Abstract

L'invention a pour objet un procédé de préparation de formes pharmaceutiques, cosmétiques ou de diagnostic par cryodessiccation d'une ou de substances en solution ou en suspension dans un solvant ou un mélange de solvants, caractérisé en ce que l'on refroidit localement et progressivement de manière contrôlée la solution ou la suspension tout en l'agitant de façon à provoquer la naissance de microcristaux de solvant qui sont mis en suspension dans le liquide restant jusqu'à obtenir un système complexe microcristallin de viscosité élevée composé essentiellement de microcristaux isolés de solvant en mélange intime avec des phases liquides interstitielles hautement concentrées en les substances initialement présentes, on durcit le système complexe microcristallin par refroidissement poussé et on lyophilise. Ce procédé permet d'obtenir notamment des formes lyophilisées ayant une vitesse de dissolution ou de dispersion plus grandes, ainsi que des compositions lyophiles des substances normalement incompatibles.
FR7728193A 1977-09-19 1977-09-19 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic Granted FR2403078A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR7728193A FR2403078A1 (fr) 1977-09-19 1977-09-19 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic
US05/875,542 US4178695A (en) 1977-09-19 1978-02-06 New process for preparing pharmaceutical, cosmetic or diagnostic formulations
IE1341/78A IE47020B1 (en) 1977-09-19 1978-07-04 Improvements in or relating to a new process for preparing pharmaceutical, cosmetic or diagnostic formulations
SE7808007A SE444645B (sv) 1977-09-19 1978-07-20 Forfarande for framstellning av farmaceutiska, kosmetiska eller diagnostiska preparat genom frystorkning
DK333678A DK154528C (da) 1977-09-19 1978-07-26 Fremgangsmaade til fremstilling af farmaceutiske, kosmetiske eller diagnostiske praeparater
GB7832497A GB2004182B (en) 1977-09-19 1978-08-07 Process for preparing pharmaceutical cosmetic or diagnostic formulations
JP10903678A JPS5495720A (en) 1977-09-19 1978-09-05 Production of medicines * cosmetics and diagnostic composition
IT51099/78A IT1106901B (it) 1977-09-19 1978-09-15 Procedimento per produrre forme farmaceutiche cosmetiche o di diagnostica
CA311,409A CA1097209A (fr) 1977-09-19 1978-09-15 Procede pour la preparation de produits cosmetiques, pharmaceutiques ou de diagnostic
DE19782840461 DE2840461A1 (de) 1977-09-19 1978-09-16 Verfahren zur herstellung von arzneimittelzubereitungen, kosmetischen oder diagnostischen praeparaten durch gefriertrocknen
CH973478A CH633445A5 (fr) 1977-09-19 1978-09-18 Procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic.
BE190539A BE870548A (fr) 1977-09-19 1978-09-18 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic
ES473459A ES473459A1 (es) 1977-09-19 1978-09-18 Procedimiento de criodesecacion de sustancias cosmeticas y de diagnostico en solucion o suspension en disolventes
LU80251A LU80251A1 (fr) 1977-09-19 1978-09-18 Nouveau procede de preparation de formes pharmaceutiques,cosmetiques ou de diagnostic
NLAANVRAGE7809522,A NL186675C (nl) 1977-09-19 1978-09-19 Werkwijze voor het bereiden van farmaceutische, cosmetische en diagnostische materialen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7728193A FR2403078A1 (fr) 1977-09-19 1977-09-19 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic

Publications (2)

Publication Number Publication Date
FR2403078A1 true FR2403078A1 (fr) 1979-04-13
FR2403078B1 FR2403078B1 (fr) 1981-07-03

Family

ID=9195532

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7728193A Granted FR2403078A1 (fr) 1977-09-19 1977-09-19 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic

Country Status (15)

Country Link
US (1) US4178695A (fr)
JP (1) JPS5495720A (fr)
BE (1) BE870548A (fr)
CA (1) CA1097209A (fr)
CH (1) CH633445A5 (fr)
DE (1) DE2840461A1 (fr)
DK (1) DK154528C (fr)
ES (1) ES473459A1 (fr)
FR (1) FR2403078A1 (fr)
GB (1) GB2004182B (fr)
IE (1) IE47020B1 (fr)
IT (1) IT1106901B (fr)
LU (1) LU80251A1 (fr)
NL (1) NL186675C (fr)
SE (1) SE444645B (fr)

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US4429542A (en) * 1981-08-10 1984-02-07 Hoxan Corporation Method of freezing fertilized ova, spermatozoa or the like and apparatus therefor
JPS58154547A (ja) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd アズレン誘導体の安定化法
ES525492A0 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US4712310A (en) * 1986-09-15 1987-12-15 E. I. Du Pont De Nemours And Company Co-spray technique
IL86892A (en) * 1987-07-08 1993-04-04 Lafon Labor Filter comprising a material obtained by freeze-drying, its preparation and its use, especially in pharmacy
JP2865320B2 (ja) * 1989-08-07 1999-03-08 株式会社資生堂 固型化粧料組成物
FR2670675B1 (fr) * 1990-12-20 1993-04-16 Lafon Labor Procede de preparation de formes pharmaceutiques stables a base d'acide acetylsalicylique ou de ses sels.
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
RU2756946C2 (ru) * 2001-01-26 2021-10-07 Мерк Шарп И Доум Корп. Применение замещенных азетидинонов для лечения ситостеролемии
BR0206639A (pt) * 2001-01-26 2004-02-25 Schering Corp Combinações de inibidor(es) da absorção do esterol com modificador(es) do sangue para o tratamento de condições vasculares
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DE60220269T2 (de) * 2001-01-26 2008-01-17 Schering Corp. Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen
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DE60221798T2 (de) * 2001-01-26 2008-06-05 Schering Corp. Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen
EP1392287B8 (fr) * 2001-05-25 2007-01-10 Schering Corporation Usage de dérivés de l'azétidinone pour le traitement de la maladie d' Alzheimer.
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US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
DE60229406D1 (de) * 2001-09-21 2008-11-27 Schering Corp Verfahren zur behandlung oder verhinderung von vaskulärer entzündung mit sterol-absorbierungs- inhibitor(en)
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DE60222160T2 (de) * 2001-10-12 2008-06-12 Elan Pharma International Ltd., Athlone Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
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MXPA05004811A (es) * 2002-11-06 2005-07-22 Schering Corp Inhibidores de absorcion de colesterol para el tratamiento de trastornos autoinmunes.
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) * 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
MXPA05009501A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1626742A1 (fr) * 2003-05-22 2006-02-22 Elan Pharma International Limited Sterilisation de dispersions d'agents actifs particulaires au moyen de rayons gamma
EP1680189A2 (fr) * 2003-11-05 2006-07-19 Schering Corporation Combinaisons de modulateurs lipidiques et d'azetidinones substituees et traitements d'affections vasculaires
NZ548331A (en) * 2004-01-28 2010-03-26 Unilever Plc Porous bodies and method of production thereof
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
EP1870649A1 (fr) 2006-06-20 2007-12-26 Octapharma AG Lyophilisation visant à obtenir une humidité résiduelle déterminée par énergie de désorption aux niveaux limités
US20090238867A1 (en) * 2007-12-13 2009-09-24 Scott Jenkins Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
FR2945950A1 (fr) 2009-05-27 2010-12-03 Elan Pharma Int Ltd Compositions de nanoparticules anticancereuses et procedes pour les preparer
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Citations (4)

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Publication number Priority date Publication date Assignee Title
US2984992A (en) * 1954-07-28 1961-05-23 Union Carbide Corp Apparatus for freeze dehydration of liquid bearing solids
FR2036890A1 (fr) * 1969-04-15 1970-12-31 Orsymonde
NL6915749A (en) * 1969-10-17 1971-04-20 Powdered products from fruit and vegetable juices aqs - vegetable extracts such as coffee, tea, etc having porous
FR2068447A1 (en) * 1969-11-26 1971-08-27 Orsymonde Dehydrated pharmaceutical comps by - lyophilisation

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US3309779A (en) * 1966-02-02 1967-03-21 Fmc Corp Dehydration of solids-bearing liquids
GB1190319A (en) * 1968-08-15 1970-05-06 George Jarvis Tooby Method for Dehydrating Materials
DE1900995A1 (de) * 1969-01-09 1970-08-27 Struthers Scient And Internat Gefriertrocknungsverfahren fuer Nahrungsmittel und dabei erhaltene Produkte
US3673698A (en) * 1970-11-25 1972-07-04 Albert S Guerard Process for freeze drying with carbon dioxide
JPS503381A (fr) * 1973-05-11 1975-01-14
JPS506532A (fr) * 1973-05-22 1975-01-23

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US2984992A (en) * 1954-07-28 1961-05-23 Union Carbide Corp Apparatus for freeze dehydration of liquid bearing solids
FR2036890A1 (fr) * 1969-04-15 1970-12-31 Orsymonde
NL6915749A (en) * 1969-10-17 1971-04-20 Powdered products from fruit and vegetable juices aqs - vegetable extracts such as coffee, tea, etc having porous
FR2068447A1 (en) * 1969-11-26 1971-08-27 Orsymonde Dehydrated pharmaceutical comps by - lyophilisation

Also Published As

Publication number Publication date
CH633445A5 (fr) 1982-12-15
IT7851099A0 (it) 1978-09-15
NL7809522A (nl) 1979-03-21
JPS62884B2 (fr) 1987-01-10
IT1106901B (it) 1985-11-18
JPS5495720A (en) 1979-07-28
DK154528C (da) 1989-04-10
IE47020B1 (en) 1983-11-30
NL186675C (nl) 1991-02-01
DE2840461C2 (fr) 1988-10-06
LU80251A1 (fr) 1979-03-07
SE7808007L (sv) 1979-03-20
IE781341L (en) 1979-03-19
GB2004182B (en) 1982-03-24
FR2403078B1 (fr) 1981-07-03
SE444645B (sv) 1986-04-28
DK154528B (da) 1988-11-21
NL186675B (nl) 1990-09-03
DK333678A (da) 1979-03-20
ES473459A1 (es) 1979-10-16
DE2840461A1 (de) 1979-03-29
CA1097209A (fr) 1981-03-10
GB2004182A (en) 1979-03-28
US4178695A (en) 1979-12-18
BE870548A (fr) 1979-03-19

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