BR112014010223A8 - inibidores de reciclagem de ácido de bílis para o tratamento de doenças hepáticas colestáticas pediatras - Google Patents

inibidores de reciclagem de ácido de bílis para o tratamento de doenças hepáticas colestáticas pediatras

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Publication number
BR112014010223A8
BR112014010223A8 BR112014010223A BR112014010223A BR112014010223A8 BR 112014010223 A8 BR112014010223 A8 BR 112014010223A8 BR 112014010223 A BR112014010223 A BR 112014010223A BR 112014010223 A BR112014010223 A BR 112014010223A BR 112014010223 A8 BR112014010223 A8 BR 112014010223A8
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BR
Brazil
Prior art keywords
pediatric
treatment
bile acid
liver disease
cholestatic liver
Prior art date
Application number
BR112014010223A
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English (en)
Other versions
BR112014010223A2 (pt
BR112014010223B8 (pt
BR112014010223B1 (pt
Inventor
Gedulin Bronislava
Grey Michael
ODONNELL Niall
Original Assignee
Lumena Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48168608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014010223(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumena Pharmaceuticals Inc filed Critical Lumena Pharmaceuticals Inc
Publication of BR112014010223A2 publication Critical patent/BR112014010223A2/pt
Publication of BR112014010223A8 publication Critical patent/BR112014010223A8/pt
Publication of BR112014010223B1 publication Critical patent/BR112014010223B1/pt
Publication of BR112014010223B8 publication Critical patent/BR112014010223B8/pt

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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

resumo inibidores de reciclagem de ácido de bílis para o tratamento de doenças hepáticas colestáticas pediatras são aqui fornecidas formas de dosagem pediátricas para o uso no tratamento de uma doença hepática colestática pediatra por administrar não sistematicamente a um indivíduo, na necessidade disso, uma quantidade terapeuticamente eficaz da forma de dosagem pediatra que compreende um inibidor de transporte de ácido biliar dependente de sódio apical (asbti) ou um sal farmaceuticamente aceitável disso. são também fornecidas referidas formas de dosagem pediatra para o uso no tratamento de uma doença hepática pediatra, para o uso em diminuição dos níveis de ácidos biliares ou de ácidos biliares hepáticos do soro, para o uso no tratamento do prurido, para o uso em redução das enzimas do fígado ou a bilirrubina que compreendem a administração, não sistematicamente, a um indivíduo na necessidade disso de uma quantidade terapeuticamente eficaz de uma formulação pediatra que compreende um asbti ou um sal farmaceuticamente aceitável disso.
BR112014010223A 2011-10-28 2012-10-26 uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica BR112014010223B8 (pt)

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US201161553094P 2011-10-28 2011-10-28
US61/553.094 2011-10-28
US201261607487P 2012-03-06 2012-03-06
US201261607503P 2012-03-06 2012-03-06
US61/607.503 2012-03-06
US61/607.487 2012-03-06
PCT/US2012/062284 WO2013063512A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

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