CH531000A - Verfahren zur Herstellung neuer Benzocycloheptathiophene - Google Patents

Verfahren zur Herstellung neuer Benzocycloheptathiophene

Info

Publication number
CH531000A
CH531000A CH1159370A CH1159370A CH531000A CH 531000 A CH531000 A CH 531000A CH 1159370 A CH1159370 A CH 1159370A CH 1159370 A CH1159370 A CH 1159370A CH 531000 A CH531000 A CH 531000A
Authority
CH
Switzerland
Prior art keywords
benzocycloheptathiophenes
preparation
new
new benzocycloheptathiophenes
Prior art date
Application number
CH1159370A
Other languages
English (en)
Inventor
Bourquin Jean-Pierre
Schwarb Gustav
Waldvogel Erwin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH359870A external-priority patent/CH533639A/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH1159370A priority Critical patent/CH531000A/de
Priority claimed from CH1412070A external-priority patent/CH537404A/de
Priority to US120738A priority patent/US3682930A/en
Priority to SU1628614A priority patent/SU512711A3/ru
Priority to FR7107901A priority patent/FR2085695B1/fr
Priority to HUSA002175 priority patent/HU162868B/hu
Priority to BE764019A priority patent/BE764019A/xx
Priority to ES389044A priority patent/ES389044A1/es
Priority to PL14675171A priority patent/PL84083B1/pl
Priority to DE2111071A priority patent/DE2111071C3/de
Priority to OA54190A priority patent/OA03692A/xx
Priority to IL36370A priority patent/IL36370A/xx
Priority to FI68371A priority patent/FI52980C/fi
Priority to CS171771A priority patent/CS185562B2/cs
Priority to LU62757D priority patent/LU62757A1/xx
Priority to YU58671A priority patent/YU35019B/xx
Priority to CA107,340A priority patent/CA960673A/en
Priority to NO90171A priority patent/NO133838C/no
Priority to DD16465971A priority patent/DD100000A5/xx
Priority to AT206471A priority patent/AT319238B/de
Priority to DK111471A priority patent/DK134404B/da
Priority to JP1302171A priority patent/JPS5217030B1/ja
Priority to NL7103174.A priority patent/NL167431C/xx
Priority to BG017004A priority patent/BG22398A3/xx
Priority to IE29971A priority patent/IE34997B1/xx
Priority to SE03074/71A priority patent/SE368954B/xx
Priority to GB2882373A priority patent/GB1355539A/en
Priority to GB2348271*A priority patent/GB1355537A/en
Priority to GB1894073A priority patent/GB1355538A/en
Priority to NLAANVRAGE7111808,A priority patent/NL171449C/xx
Priority to BE771964A priority patent/BE771964A/xx
Priority to CA121,762A priority patent/CA947767A/en
Priority to AT766471A priority patent/AT321905B/de
Priority to LU63829D priority patent/LU63829A1/xx
Priority to SE7111154A priority patent/SE378820B/xx
Priority to FR7131866A priority patent/FR2107917B1/fr
Priority to OA54351A priority patent/OA03786A/xx
Priority to DE19712144490 priority patent/DE2144490A1/de
Priority to US00178449A priority patent/US3770728A/en
Priority to GB4392471A priority patent/GB1360219A/en
Priority to US00278244A priority patent/US3749786A/en
Priority to US00278738A priority patent/US3853915A/en
Priority to CA152,330A priority patent/CA966839A/en
Publication of CH531000A publication Critical patent/CH531000A/de
Priority to ES416480A priority patent/ES416480A1/es
Priority to IE149474A priority patent/IE34998B1/xx
Priority to YU69978A priority patent/YU35254B/xx
Priority to IT7827770A priority patent/IT7827770A0/it
Priority to MY8300201A priority patent/MY8300201A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80—Seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
CH1159370A 1970-03-11 1970-07-31 Verfahren zur Herstellung neuer Benzocycloheptathiophene CH531000A (de)

Priority Applications (47)

Application Number Priority Date Filing Date Title
CH1159370A CH531000A (de) 1970-03-11 1970-07-31 Verfahren zur Herstellung neuer Benzocycloheptathiophene
US120738A US3682930A (en) 1970-03-11 1971-03-03 4(1-alkyl-4-piperidylidine)-4h-benzo {84,5{9 {0 cyclohepta {8 1,2{14 6{9
SU1628614A SU512711A3 (ru) 1970-03-11 1971-03-05 Способ получени производных бензо-(4,5)-циклогепта (1,2-в) -тиофена
FR7107901A FR2085695B1 (de) 1970-03-11 1971-03-08
HUSA002175 HU162868B (de) 1970-03-11 1971-03-09
BE764019A BE764019A (fr) 1970-03-11 1971-03-09 Nouveaux derives du benzo-cyclohepta-thiophene et leur preparation
ES389044A ES389044A1 (es) 1970-03-11 1971-03-09 Procedimiento para la obtencion de derivados del benzoci- cloheptatiofeno.
PL14675171A PL84083B1 (de) 1970-03-11 1971-03-09
DE2111071A DE2111071C3 (de) 1970-03-11 1971-03-09 4-(l-Alkyl-4-piperidyuden)-4H-benzo [4,5] cyclohepta [1,2-b] thiophen-10 (9H)-one bzw. -9 (10H)-one, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
OA54190A OA03692A (fr) 1970-03-11 1971-03-09 Nouveaux dérivés du benzo-cyclohepta-thiopène et leur préparation.
IL36370A IL36370A (en) 1970-03-11 1971-03-09 4-piperidylidene-benzocyclohepta-thiophene derivatives,their preparation and pharmaceutical compositions containing them
FI68371A FI52980C (de) 1970-03-11 1971-03-09
CS171771A CS185562B2 (en) 1970-03-11 1971-03-09 Method of producing new 4-/1-alkyl-4-piperidyliden/-4h-benzo/4,5/cyclohepta/1,2-b/thiophen-9/10h/-ones or 10/9h/-ones
LU62757D LU62757A1 (de) 1970-03-11 1971-03-09
YU58671A YU35019B (en) 1970-03-11 1971-03-09 Process for preparing novel 4-(1-alkyl-4-piperidylidene)-4h-benzo(4,5)cyclohepta(1,2-)tiophene-10(9h)-ones or-9(10h)-ones
CA107,340A CA960673A (en) 1970-03-11 1971-03-10 Piperidylidene benzocycloheptathiophenes
NO90171A NO133838C (de) 1970-03-11 1971-03-10
DD16465971A DD100000A5 (de) 1970-03-11 1971-03-10
AT206471A AT319238B (de) 1970-03-11 1971-03-10 Verfahren zur Herstellung neuer 4-(1-Alkyl-4-piperidyliden)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-9(10H)- bzw. 10(9H)-on-Verbindungen und ihrer Säureadditionssalze
DK111471A DK134404B (da) 1970-03-11 1971-03-10 Analogifremgangsmåde til fremstilling af benzocycloheptathiophenderivater eller syreadditionssalte deraf.
JP1302171A JPS5217030B1 (de) 1970-03-11 1971-03-10
NL7103174.A NL167431C (nl) 1970-03-11 1971-03-10 Werkwijze voor de bereiding van een histaminolytisch werkend preparaat en werkwijze voor de bereiding van een histaminolytisch werkend 4-(1-alkyl-4-piperidyli- deen)benzoŸ4,5ŸcycloheptaŸ1,2-bŸthiofeen
BG017004A BG22398A3 (bg) 1970-03-11 1971-03-10 Метод за получаване на хетероциклени съединения
IE29971A IE34997B1 (en) 1970-03-11 1971-03-10 4-piperidylidene-benzocycloheptathiopenes
SE03074/71A SE368954B (de) 1970-03-11 1971-03-10
GB2882373A GB1355539A (en) 1970-03-11 1971-04-19 Benzocycloheptathiophene derivative
GB2348271*A GB1355537A (en) 1970-03-11 1971-04-19 4-piperidylidene-benzocycloheptathiophenes
GB1894073A GB1355538A (en) 1970-03-11 1971-06-04 Benzocycloheptathiophene derivatives
NLAANVRAGE7111808,A NL171449C (nl) 1970-03-11 1971-08-27 Werkwijze ter bereiding van een met een aminoalkylideengroep gesubstitueerd tricyclisch keton.
BE771964A BE771964A (fr) 1970-03-11 1971-08-30 Procede pour la preparation de derives du benzo-cyclohepta-thiophene
CA121,762A CA947767A (en) 1970-03-11 1971-08-31 Process for the production of benzocyclohep thathiophenones
AT766471A AT321905B (de) 1970-03-11 1971-09-02 Verfahren zur herstellung neuer thiophenderivate und ihrer salze
LU63829D LU63829A1 (de) 1970-03-11 1971-09-02
SE7111154A SE378820B (de) 1970-03-11 1971-09-03
FR7131866A FR2107917B1 (de) 1970-03-11 1971-09-03
OA54351A OA03786A (fr) 1970-03-11 1971-09-03 Procédé pour la préparation de dérivés du benzo-cyclohepta-thiophène.
DE19712144490 DE2144490A1 (de) 1970-03-11 1971-09-06 Neue heterocyclische Verbindungen und Verfahren zu deren Herstellung
US00178449A US3770728A (en) 1970-03-11 1971-09-07 Substituted 4h-benzo(4,5)cyclohepta(1,2-b)thiophen-10(9h)-ones
GB4392471A GB1360219A (en) 1970-03-11 1971-09-21 4h-benzo-4,5 - cyclohepta-1,2 - b-thiophen-9-ones and process for their manufacture
US00278244A US3749786A (en) 1970-03-11 1972-08-07 Organic compounds in treating allergic conditions
US00278738A US3853915A (en) 1970-03-11 1972-08-08 9-or 10-halo-4h-benzo{8 4,5{9 cyclo-hepta{8 1,2-b{9 thiophen-4-ones
CA152,330A CA966839A (en) 1970-03-11 1972-09-22 Piperidylidene banzocycloheptathiophanes
ES416480A ES416480A1 (es) 1970-03-11 1973-06-30 Procedimiento para la obtencion de derivados del benzocic- loheptatiofeno.
IE149474A IE34998B1 (en) 1970-03-11 1974-07-15 A benzocycloheptathiophene derivative
YU69978A YU35254B (en) 1970-03-11 1978-03-24 Process for preparing novel 4-(-alkyl-4-piperidylidene)-4h-benzol(4,5)cyclohepta(1,2,-b)thiophene-10(9h)-ones
IT7827770A IT7827770A0 (it) 1970-03-11 1978-09-15 Che contengono questi derivati. derivati delbenzo-cicloepta-tiofene, loro preparazione e prodotti medicinali
MY8300201A MY8300201A (en) 1970-03-11 1983-12-30 A benzocycloheptathiophene derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH359870A CH533639A (de) 1970-03-11 1970-03-11 Verfahren zur Herstellung neuer Benzo(4,5)cyclohepta(1,2-b)-thiophen-Derivate
CH1159370A CH531000A (de) 1970-03-11 1970-07-31 Verfahren zur Herstellung neuer Benzocycloheptathiophene
CH1412070A CH537404A (de) 1970-09-24 1970-09-24 Verfahren zur Herstellung neuer Thiophenderivate
CH163271 1971-02-04

Publications (1)

Publication Number Publication Date
CH531000A true CH531000A (de) 1972-11-30

Family

ID=27428249

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1159370A CH531000A (de) 1970-03-11 1970-07-31 Verfahren zur Herstellung neuer Benzocycloheptathiophene

Country Status (12)

Country Link
US (4) US3682930A (de)
AT (2) AT319238B (de)
BE (2) BE764019A (de)
CA (2) CA960673A (de)
CH (1) CH531000A (de)
DE (2) DE2111071C3 (de)
FR (2) FR2085695B1 (de)
GB (4) GB1355539A (de)
LU (2) LU62757A1 (de)
NL (2) NL167431C (de)
OA (2) OA03692A (de)
SE (2) SE368954B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3960894A (en) * 1972-01-24 1976-06-01 Sandoz Ltd. 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
BE794377A (fr) * 1972-01-24 1973-07-23 Sandoz Sa Nouveaux derives du benzo-cyclohepta-thiophene
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
CA1041100A (en) * 1973-10-04 1978-10-24 Herbert G. Johnson Pyridine-diyldioxamic acid and derivatives
CH580621A5 (de) * 1973-10-08 1976-10-15 Sandoz Ag
US4073915A (en) * 1975-05-20 1978-02-14 Sandoz Ltd. Treating asthma
FI761607A (de) * 1975-06-16 1976-12-17 Sandoz Ag
US4128549A (en) * 1976-02-27 1978-12-05 Sandoz Ltd. Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
NL8701335A (nl) * 1986-06-21 1988-01-18 Sandoz Ag Orale farmaceutische preparaten.
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
DZ1460A1 (fr) * 1989-11-22 2004-09-13 Sod Conseils Rech Applic Nouveaux dérivés du sélénophèn ainsi que leur procédé de préparation.
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
CA2093797C (en) * 1990-10-10 1998-09-22 Richard J. Friary Substituted imidazobenzazepines and imidazopyridoazepines
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
WO1998056381A1 (en) * 1997-06-09 1998-12-17 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
ATE516804T1 (de) * 1999-09-13 2011-08-15 Bridge Pharma Inc Optisch aktive isomere von ketotifen und deren therapeutisch wirksame metabolite
WO2001039774A1 (en) * 1999-12-01 2001-06-07 Klein Pharmaceuticals Topical administration of ketotifen
US20030212078A1 (en) * 2001-05-17 2003-11-13 Klein Gerald L. Topical administration of pharmacological compositions for non-systemic treatment of pruritus
EP3025718A1 (de) * 2003-01-14 2016-06-01 Gilead Sciences, Inc. Zusammensetzungen und verfahren für antivirale kombinationstherapie
CN100381439C (zh) * 2005-04-05 2008-04-16 浙江华海药业股份有限公司 9,10-二溴-9,10-二氢-4-H苯并[4,5]环庚烯并[1,2-b]噻吩-4-酮的制备方法
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
US20100166804A1 (en) * 2007-05-23 2010-07-01 Dennis Penn Methods
CA2713293A1 (en) 2008-01-30 2009-08-06 Nippon Zoki Pharmaceutical Co., Ltd. Piperidine derivative
WO2009142772A2 (en) 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
CA2732282C (en) * 2008-08-01 2016-03-29 Nippon Zoki Pharmaceutical Co., Ltd. Aminopropylidene derivative
AU2010279164A1 (en) * 2009-07-28 2012-02-02 Nippon Zoki Pharmaceutical Co., Ltd. Method for producing thiabenzoazulene propionic acid derivative
MX354242B (es) 2011-10-28 2018-02-20 Lumena Pharmaceuticals Inc Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.
US8557846B1 (en) 2012-10-23 2013-10-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in dogs
US8778971B2 (en) 2012-10-23 2014-07-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in companion animals
US20140120121A1 (en) 2012-10-30 2014-05-01 Bridge Pharma, Inc. Medicinal treatment of atopic inflammatory diseases
US20150272941A1 (en) 2012-10-30 2015-10-01 Bridge Pharma, Inc. Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US9345697B2 (en) 2013-08-06 2016-05-24 Bridge Pharma, Inc. Methods of treatment of non-histaminic pruritus
US9439895B2 (en) 2013-08-06 2016-09-13 Bridge Pharma, Inc. Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients
US9138431B2 (en) 2013-08-06 2015-09-22 Bridge Pharma, Inc. Methods of treatment of histamine H-4 receptor-related pruritus
ES2703693T3 (es) 2015-06-11 2019-03-12 Bridge Pharma Inc Métodos de tratamiento del prurito no histamínico en mamíferos
MX2018011699A (es) 2018-09-26 2019-07-24 Federico Amezcua Amezcua Composicion farmaceutica sinergica de un antagonista de los receptores de leucotrienos y un agonista inverso de la histamina h1.
US10959992B2 (en) 2019-02-22 2021-03-30 Bridge Pharma Inc. Methods of treatment of asthma and COPD

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137020C (de) * 1962-08-31
FR1437412A (fr) * 1963-12-19 1966-05-06 Sandoz Sa Nouveaux benzo-cyclohepta-thiophènes et leur préparation
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
GB1084448A (en) * 1963-12-20 1967-09-20 Sandoz Ltd Improvements in or relating to 4h-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one derivatives
CH537897A (de) * 1968-03-20 1973-06-15 Hoffmann La Roche Verfahren zur Herstellung von tricyclischen Verbindungen
US3574199A (en) * 1968-06-28 1971-04-06 Searle & Co 6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3709947A (en) * 1971-07-26 1973-01-09 Searle & Co 6-chloropropylidene-1,1a,6,10b-tetrahydrobenzo(a,e)cyclopropa(c)cycloheptenes

Also Published As

Publication number Publication date
BE764019A (fr) 1971-09-09
CA960673A (en) 1975-01-07
SE378820B (de) 1975-09-15
OA03692A (fr) 1971-12-24
NL167431C (nl) 1981-12-16
DE2111071A1 (de) 1971-09-23
GB1355539A (en) 1974-06-05
LU63829A1 (de) 1972-06-27
DE2111071B2 (de) 1978-11-09
DE2111071C3 (de) 1979-07-12
FR2085695A1 (de) 1971-12-31
AT321905B (de) 1975-04-25
FR2107917A1 (de) 1972-05-12
LU62757A1 (de) 1971-10-13
NL7111808A (de) 1972-03-28
GB1355537A (en) 1974-06-05
US3682930A (en) 1972-08-08
DE2144490A1 (de) 1972-03-30
AT319238B (de) 1974-12-10
US3853915A (en) 1974-12-10
GB1360219A (en) 1974-07-17
SE368954B (de) 1974-07-29
GB1355538A (en) 1974-06-05
US3770728A (en) 1973-11-06
NL171449C (nl) 1983-04-05
CA947767A (en) 1974-05-21
BE771964A (fr) 1972-02-29
FR2107917B1 (de) 1975-04-18
US3749786A (en) 1973-07-31
NL7103174A (de) 1971-09-14
FR2085695B1 (de) 1974-11-15
OA03786A (fr) 1971-12-24

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