CH531000A - Process for the preparation of new benzocycloheptathiophenes - Google Patents

Process for the preparation of new benzocycloheptathiophenes

Info

Publication number
CH531000A
CH531000A CH1159370A CH1159370A CH531000A CH 531000 A CH531000 A CH 531000A CH 1159370 A CH1159370 A CH 1159370A CH 1159370 A CH1159370 A CH 1159370A CH 531000 A CH531000 A CH 531000A
Authority
CH
Switzerland
Prior art keywords
benzocycloheptathiophenes
preparation
new
new benzocycloheptathiophenes
Prior art date
Application number
CH1159370A
Other languages
German (de)
Inventor
Bourquin Jean-Pierre
Schwarb Gustav
Waldvogel Erwin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH359870A external-priority patent/CH533639A/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH1159370A priority Critical patent/CH531000A/en
Priority claimed from CH1412070A external-priority patent/CH537404A/en
Priority to US120738A priority patent/US3682930A/en
Priority to SU1628614A priority patent/SU512711A3/en
Priority to FR7107901A priority patent/FR2085695B1/fr
Priority to OA54190A priority patent/OA03692A/en
Priority to DE2111071A priority patent/DE2111071C3/en
Priority to LU62757D priority patent/LU62757A1/xx
Priority to FI68371A priority patent/FI52980C/fi
Priority to ES389044A priority patent/ES389044A1/en
Priority to IL36370A priority patent/IL36370A/en
Priority to CS171771A priority patent/CS185562B2/en
Priority to BE764019A priority patent/BE764019A/en
Priority to HUSA002175 priority patent/HU162868B/hu
Priority to YU58671A priority patent/YU35019B/en
Priority to PL14675171A priority patent/PL84083B1/pl
Priority to NO90171A priority patent/NO133838C/no
Priority to AT206471A priority patent/AT319238B/en
Priority to SE03074/71A priority patent/SE368954B/xx
Priority to DD16465971A priority patent/DD100000A5/xx
Priority to NL7103174.A priority patent/NL167431C/en
Priority to BG017004A priority patent/BG22398A3/en
Priority to CA107,340A priority patent/CA960673A/en
Priority to JP46013021A priority patent/JPS5217030B1/ja
Priority to IE29971A priority patent/IE34997B1/en
Priority to DK111471A priority patent/DK134404B/en
Priority to GB2348271*A priority patent/GB1355537A/en
Priority to GB2882373A priority patent/GB1355539A/en
Priority to GB1894073A priority patent/GB1355538A/en
Priority to NLAANVRAGE7111808,A priority patent/NL171449C/en
Priority to BE771964A priority patent/BE771964A/en
Priority to CA121,762A priority patent/CA947767A/en
Priority to LU63829D priority patent/LU63829A1/xx
Priority to AT766471A priority patent/AT321905B/en
Priority to OA54351A priority patent/OA03786A/en
Priority to FR7131866A priority patent/FR2107917B1/fr
Priority to SE7111154A priority patent/SE378820B/xx
Priority to DE19712144490 priority patent/DE2144490A1/en
Priority to US00178449A priority patent/US3770728A/en
Priority to GB4392471A priority patent/GB1360219A/en
Priority to US00278244A priority patent/US3749786A/en
Priority to US00278738A priority patent/US3853915A/en
Priority to CA152,330A priority patent/CA966839A/en
Publication of CH531000A publication Critical patent/CH531000A/en
Priority to ES416480A priority patent/ES416480A1/en
Priority to IE149474A priority patent/IE34998B1/en
Priority to YU69978A priority patent/YU35254B/en
Priority to IT7827770A priority patent/IT7827770A0/en
Priority to MY8300201A priority patent/MY8300201A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80—Seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CH1159370A 1970-03-11 1970-07-31 Process for the preparation of new benzocycloheptathiophenes CH531000A (en)

Priority Applications (47)

Application Number Priority Date Filing Date Title
CH1159370A CH531000A (en) 1970-03-11 1970-07-31 Process for the preparation of new benzocycloheptathiophenes
US120738A US3682930A (en) 1970-03-11 1971-03-03 4(1-alkyl-4-piperidylidine)-4h-benzo {84,5{9 {0 cyclohepta {8 1,2{14 6{9
SU1628614A SU512711A3 (en) 1970-03-11 1971-03-05 Method for preparing benzo (4,5) -cyclohepta (1,2-b) -thiophene derivatives
FR7107901A FR2085695B1 (en) 1970-03-11 1971-03-08
OA54190A OA03692A (en) 1970-03-11 1971-03-09 New derivatives of benzo-cyclohepta-thiopene and their preparation.
DE2111071A DE2111071C3 (en) 1970-03-11 1971-03-09 4- (1-Alkyl-4-piperidyuden) -4H-benzo [4,5] cyclohepta [1,2-b] thiophen-10 (9H) -ones or -9 (10H) -ones, process for their preparation as well as medicaments containing these compounds
LU62757D LU62757A1 (en) 1970-03-11 1971-03-09
FI68371A FI52980C (en) 1970-03-11 1971-03-09
ES389044A ES389044A1 (en) 1970-03-11 1971-03-09 Procedure for the obtaining of derivatives of benzoci-cloheptatiofeno. (Machine-translation by Google Translate, not legally binding)
IL36370A IL36370A (en) 1970-03-11 1971-03-09 4-piperidylidene-benzocyclohepta-thiophene derivatives,their preparation and pharmaceutical compositions containing them
CS171771A CS185562B2 (en) 1970-03-11 1971-03-09 Method of producing new 4-/1-alkyl-4-piperidyliden/-4h-benzo/4,5/cyclohepta/1,2-b/thiophen-9/10h/-ones or 10/9h/-ones
BE764019A BE764019A (en) 1970-03-11 1971-03-09 NEW DERIVATIVES OF BENZO-CYCLOHEPTA-THIOPHENE AND THEIR PREPARATION
HUSA002175 HU162868B (en) 1970-03-11 1971-03-09
YU58671A YU35019B (en) 1970-03-11 1971-03-09 Process for preparing novel 4-(1-alkyl-4-piperidylidene)-4h-benzo(4,5)cyclohepta(1,2-)tiophene-10(9h)-ones or-9(10h)-ones
PL14675171A PL84083B1 (en) 1970-03-11 1971-03-09
NO90171A NO133838C (en) 1970-03-11 1971-03-10
AT206471A AT319238B (en) 1970-03-11 1971-03-10 Process for the preparation of new 4- (1-alkyl-4-piperidylidene) -4H-benzo [4,5] cyclohepta [1,2-b] thiophen-9 (10H) - or 10 (9H) -one compounds and their acid addition salts
SE03074/71A SE368954B (en) 1970-03-11 1971-03-10
DD16465971A DD100000A5 (en) 1970-03-11 1971-03-10
NL7103174.A NL167431C (en) 1970-03-11 1971-03-10 PROCEDURE FOR THE PREPARATION OF A HISTAMINOLYTICALLY ACTIVE PREPARATION AND PROCESSES FOR THE PREPARATION OF A HISTAMINOLYTICALLY ACTIVE 4-(1-ALKYL-4-PIPERIDYLIDENE)BENZOŸ4,5ŸCYCLOHEPTAŸ1,2-BETHIOphene
BG017004A BG22398A3 (en) 1970-03-11 1971-03-10 METHOD FOR OBTAINING HETEROCYCLIC COMPOUNDS
CA107,340A CA960673A (en) 1970-03-11 1971-03-10 Piperidylidene benzocycloheptathiophenes
JP46013021A JPS5217030B1 (en) 1970-03-11 1971-03-10
IE29971A IE34997B1 (en) 1970-03-11 1971-03-10 4-piperidylidene-benzocycloheptathiopenes
DK111471A DK134404B (en) 1970-03-11 1971-03-10 Analogous process for the preparation of benzocycloheptathiophene derivatives or acid addition salts thereof.
GB2348271*A GB1355537A (en) 1970-03-11 1971-04-19 4-piperidylidene-benzocycloheptathiophenes
GB2882373A GB1355539A (en) 1970-03-11 1971-04-19 Benzocycloheptathiophene derivative
GB1894073A GB1355538A (en) 1970-03-11 1971-06-04 Benzocycloheptathiophene derivatives
NLAANVRAGE7111808,A NL171449C (en) 1970-03-11 1971-08-27 PROCESS FOR PREPARING A TRICYCLIC KETONE SUBSTITUTED WITH AN AMINO ALKYLIDE GROUP
BE771964A BE771964A (en) 1970-03-11 1971-08-30 PROCESS FOR THE PREPARATION OF BENZO-CYCLOHEPTA-THIOPHENE DERIVATIVES
CA121,762A CA947767A (en) 1970-03-11 1971-08-31 Process for the production of benzocyclohep thathiophenones
LU63829D LU63829A1 (en) 1970-03-11 1971-09-02
AT766471A AT321905B (en) 1970-03-11 1971-09-02 PROCESS FOR PRODUCING NEW THIOPHEN DERIVATIVES AND THEIR SALTS
OA54351A OA03786A (en) 1970-03-11 1971-09-03 Process for the preparation of benzo-cyclohepta-thiophene derivatives.
FR7131866A FR2107917B1 (en) 1970-03-11 1971-09-03
SE7111154A SE378820B (en) 1970-03-11 1971-09-03
DE19712144490 DE2144490A1 (en) 1970-03-11 1971-09-06 New heterocyclic compounds and processes for their preparation
US00178449A US3770728A (en) 1970-03-11 1971-09-07 Substituted 4h-benzo(4,5)cyclohepta(1,2-b)thiophen-10(9h)-ones
GB4392471A GB1360219A (en) 1970-03-11 1971-09-21 4h-benzo-4,5 - cyclohepta-1,2 - b-thiophen-9-ones and process for their manufacture
US00278244A US3749786A (en) 1970-03-11 1972-08-07 Organic compounds in treating allergic conditions
US00278738A US3853915A (en) 1970-03-11 1972-08-08 9-or 10-halo-4h-benzo{8 4,5{9 cyclo-hepta{8 1,2-b{9 thiophen-4-ones
CA152,330A CA966839A (en) 1970-03-11 1972-09-22 Piperidylidene banzocycloheptathiophanes
ES416480A ES416480A1 (en) 1970-03-11 1973-06-30 PROCEDURE FOR OBTAINING BENZOCICLOHEPTATIOPHENE DERIVATIVES.
IE149474A IE34998B1 (en) 1970-03-11 1974-07-15 A benzocycloheptathiophene derivative
YU69978A YU35254B (en) 1970-03-11 1978-03-24 Process for preparing novel 4-(-alkyl-4-piperidylidene)-4h-benzol(4,5)cyclohepta(1,2,-b)thiophene-10(9h)-ones
IT7827770A IT7827770A0 (en) 1970-03-11 1978-09-15 WHICH CONTAIN THESE DERIVATIVES. BENZO-CYCLOHEPTHA-THIOPHENE DERIVATIVES, THEIR PREPARATION AND MEDICINAL PRODUCTS
MY8300201A MY8300201A (en) 1970-03-11 1983-12-30 A benzocycloheptathiophene derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH359870A CH533639A (en) 1970-03-11 1970-03-11 Benzo cyclo hepta-thiophenes
CH1159370A CH531000A (en) 1970-03-11 1970-07-31 Process for the preparation of new benzocycloheptathiophenes
CH1412070A CH537404A (en) 1970-09-24 1970-09-24 Benzocyclo heptathiophene prodn - esp 4-(amino alkylidene) -4h- benzo (4,5) cyclohepta(1,2-b) thiophene-10 (9h) - ones from the
CH163271 1971-02-04

Publications (1)

Publication Number Publication Date
CH531000A true CH531000A (en) 1972-11-30

Family

ID=27428249

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1159370A CH531000A (en) 1970-03-11 1970-07-31 Process for the preparation of new benzocycloheptathiophenes

Country Status (12)

Country Link
US (4) US3682930A (en)
AT (2) AT319238B (en)
BE (2) BE764019A (en)
CA (2) CA960673A (en)
CH (1) CH531000A (en)
DE (2) DE2111071C3 (en)
FR (2) FR2085695B1 (en)
GB (4) GB1355537A (en)
LU (2) LU62757A1 (en)
NL (2) NL167431C (en)
OA (2) OA03692A (en)
SE (2) SE368954B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH531000A (en) * 1970-03-11 1972-11-30 Sandoz Ag Process for the preparation of new benzocycloheptathiophenes
US3960894A (en) * 1972-01-24 1976-06-01 Sandoz Ltd. 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
BE794377A (en) * 1972-01-24 1973-07-23 Sandoz Sa NEW DERIVATIVES OF BENZO-CYCLOHEPTA-THIOPHENE
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
CA1041100A (en) * 1973-10-04 1978-10-24 Herbert G. Johnson Pyridine-diyldioxamic acid and derivatives
CH580621A5 (en) * 1973-10-08 1976-10-15 Sandoz Ag
US4073915A (en) * 1975-05-20 1978-02-14 Sandoz Ltd. Treating asthma
FI761607A7 (en) * 1975-06-16 1976-12-17 Sandoz Ag
US4128549A (en) * 1976-02-27 1978-12-05 Sandoz Ltd. Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3045135A1 (en) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach BODEGRADABLE POLYMERS CONTAINING PHARMACEUTICAL COMPOSITIONS
NL8701335A (en) * 1986-06-21 1988-01-18 Sandoz Ag ORAL PHARMACEUTICAL PREPARATIONS.
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
DZ1460A1 (en) * 1989-11-22 2004-09-13 Sod Conseils Rech Applic New selenophen derivatives and their preparation process.
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
JPH089616B2 (en) * 1990-10-10 1996-01-31 シェリング・コーポレーション Substituted imidazobenzazepines and imidazopyridazepines
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
WO1998056381A1 (en) * 1997-06-09 1998-12-17 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
ATE516804T1 (en) * 1999-09-13 2011-08-15 Bridge Pharma Inc OPTICALLY ACTIVE ISOMERS OF KETOTIFEN AND THEIR THERAPEUTIC METABOLITES
AU5139800A (en) * 1999-12-01 2001-06-12 Klein Pharmaceuticals Topical administration of ketotifen
US20030212078A1 (en) * 2001-05-17 2003-11-13 Klein Gerald L. Topical administration of pharmacological compositions for non-systemic treatment of pruritus
HRP20140379A2 (en) * 2003-01-14 2014-07-18 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
CN100381439C (en) * 2005-04-05 2008-04-16 浙江华海药业股份有限公司 Preparation method of 9,10-dibromo-9,10-dihydro-4-H-benzo[4,5]cyclohepteno[1,2-b]thiophen-4-one
TWI471145B (en) * 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc Unitary pharmaceutical dosage form
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2008153761A1 (en) * 2007-05-23 2008-12-18 Mastcell Pharmaceuticals, Inc. Methods
MX2010008400A (en) 2008-01-30 2010-08-23 Nippon Zoki Pharmaceutical Co Piperidine derivative.
WO2009142772A2 (en) 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
CA2732282C (en) * 2008-08-01 2016-03-29 Nippon Zoki Pharmaceutical Co., Ltd. Aminopropylidene derivative
CN102471326B (en) * 2009-07-28 2015-04-29 日本脏器制药株式会社 Method for producing thiabenzoazulene propionic acid derivative
KR20190135545A (en) 2011-10-28 2019-12-06 루메나 파마수티컬즈, 인코포레이티드 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
MX369466B (en) 2011-10-28 2019-11-08 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases.
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NL297097A (en) * 1962-08-31
FR1437412A (en) * 1963-12-19 1966-05-06 Sandoz Sa New benzo-cyclohepta-thiophenes and their preparation
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
GB1084448A (en) * 1963-12-20 1967-09-20 Sandoz Ltd Improvements in or relating to 4h-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one derivatives
CH537897A (en) * 1968-03-20 1973-06-15 Hoffmann La Roche Process for the preparation of tricyclic compounds
US3574199A (en) * 1968-06-28 1971-04-06 Searle & Co 6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes
CH531000A (en) * 1970-03-11 1972-11-30 Sandoz Ag Process for the preparation of new benzocycloheptathiophenes
US3709947A (en) * 1971-07-26 1973-01-09 Searle & Co 6-chloropropylidene-1,1a,6,10b-tetrahydrobenzo(a,e)cyclopropa(c)cycloheptenes

Also Published As

Publication number Publication date
US3749786A (en) 1973-07-31
OA03786A (en) 1971-12-24
GB1355539A (en) 1974-06-05
FR2107917B1 (en) 1975-04-18
DE2111071A1 (en) 1971-09-23
US3682930A (en) 1972-08-08
AT319238B (en) 1974-12-10
GB1355538A (en) 1974-06-05
FR2085695B1 (en) 1974-11-15
FR2085695A1 (en) 1971-12-31
US3853915A (en) 1974-12-10
NL171449C (en) 1983-04-05
LU62757A1 (en) 1971-10-13
NL167431C (en) 1981-12-16
NL7103174A (en) 1971-09-14
AT321905B (en) 1975-04-25
SE368954B (en) 1974-07-29
FR2107917A1 (en) 1972-05-12
GB1355537A (en) 1974-06-05
LU63829A1 (en) 1972-06-27
GB1360219A (en) 1974-07-17
BE771964A (en) 1972-02-29
SE378820B (en) 1975-09-15
BE764019A (en) 1971-09-09
CA960673A (en) 1975-01-07
DE2111071C3 (en) 1979-07-12
US3770728A (en) 1973-11-06
CA947767A (en) 1974-05-21
DE2144490A1 (en) 1972-03-30
DE2111071B2 (en) 1978-11-09
OA03692A (en) 1971-12-24
NL7111808A (en) 1972-03-28

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PL Patent ceased