AT321905B - Verfahren zur herstellung neuer thiophenderivate und ihrer salze - Google Patents

Verfahren zur herstellung neuer thiophenderivate und ihrer salze

Info

Publication number
AT321905B
AT321905B AT766471A AT766471A AT321905B AT 321905 B AT321905 B AT 321905B AT 766471 A AT766471 A AT 766471A AT 766471 A AT766471 A AT 766471A AT 321905 B AT321905 B AT 321905B
Authority
AT
Austria
Prior art keywords
salts
producing new
thiophen derivatives
thiophen
derivatives
Prior art date
Application number
AT766471A
Other languages
English (en)
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH359870A external-priority patent/CH533639A/de
Priority claimed from CH1412070A external-priority patent/CH537404A/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of AT321905B publication Critical patent/AT321905B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80—Seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT766471A 1970-03-11 1971-09-02 Verfahren zur herstellung neuer thiophenderivate und ihrer salze AT321905B (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH359870A CH533639A (de) 1970-03-11 1970-03-11 Verfahren zur Herstellung neuer Benzo(4,5)cyclohepta(1,2-b)-thiophen-Derivate
CH1159370A CH531000A (de) 1970-03-11 1970-07-31 Verfahren zur Herstellung neuer Benzocycloheptathiophene
CH1412070A CH537404A (de) 1970-09-24 1970-09-24 Verfahren zur Herstellung neuer Thiophenderivate
CH163271 1971-02-04

Publications (1)

Publication Number Publication Date
AT321905B true AT321905B (de) 1975-04-25

Family

ID=27428249

Family Applications (2)

Application Number Title Priority Date Filing Date
AT206471A AT319238B (de) 1970-03-11 1971-03-10 Verfahren zur Herstellung neuer 4-(1-Alkyl-4-piperidyliden)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-9(10H)- bzw. 10(9H)-on-Verbindungen und ihrer Säureadditionssalze
AT766471A AT321905B (de) 1970-03-11 1971-09-02 Verfahren zur herstellung neuer thiophenderivate und ihrer salze

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT206471A AT319238B (de) 1970-03-11 1971-03-10 Verfahren zur Herstellung neuer 4-(1-Alkyl-4-piperidyliden)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-9(10H)- bzw. 10(9H)-on-Verbindungen und ihrer Säureadditionssalze

Country Status (12)

Country Link
US (4) US3682930A (de)
AT (2) AT319238B (de)
BE (2) BE764019A (de)
CA (2) CA960673A (de)
CH (1) CH531000A (de)
DE (2) DE2111071C3 (de)
FR (2) FR2085695B1 (de)
GB (4) GB1355539A (de)
LU (2) LU62757A1 (de)
NL (2) NL167431C (de)
OA (2) OA03692A (de)
SE (2) SE368954B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
BE794377A (fr) * 1972-01-24 1973-07-23 Sandoz Sa Nouveaux derives du benzo-cyclohepta-thiophene
US3960894A (en) * 1972-01-24 1976-06-01 Sandoz Ltd. 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
CA1041100A (en) * 1973-10-04 1978-10-24 Herbert G. Johnson Pyridine-diyldioxamic acid and derivatives
CH580621A5 (de) * 1973-10-08 1976-10-15 Sandoz Ag
US4073915A (en) * 1975-05-20 1978-02-14 Sandoz Ltd. Treating asthma
FI761607A7 (de) * 1975-06-16 1976-12-17 Sandoz Ag
US4128549A (en) * 1976-02-27 1978-12-05 Sandoz Ltd. Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
NL8701335A (nl) * 1986-06-21 1988-01-18 Sandoz Ag Orale farmaceutische preparaten.
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
DZ1460A1 (fr) * 1989-11-22 2004-09-13 Sod Conseils Rech Applic Nouveaux dérivés du sélénophèn ainsi que leur procédé de préparation.
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
EP0552292B1 (de) * 1990-10-10 1995-06-21 Schering Corporation Substituierte imidazobenzazepine und imidazopyridoazepine
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US6207684B1 (en) 1997-06-09 2001-03-27 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
PL353586A1 (en) 1999-09-13 2003-12-01 Bridge Pharma, Inc.Bridge Pharma, Inc. Optically active isomers of ketotifen and therapeutically active metabolites thereof
AU5139800A (en) * 1999-12-01 2001-06-12 Klein Pharmaceuticals Topical administration of ketotifen
US20030212078A1 (en) * 2001-05-17 2003-11-13 Klein Gerald L. Topical administration of pharmacological compositions for non-systemic treatment of pruritus
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
CN100381439C (zh) * 2005-04-05 2008-04-16 浙江华海药业股份有限公司 9,10-二溴-9,10-二氢-4-H苯并[4,5]环庚烯并[1,2-b]噻吩-4-酮的制备方法
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
WO2008153761A1 (en) * 2007-05-23 2008-12-18 Mastcell Pharmaceuticals, Inc. Methods
TWI429641B (zh) 2008-01-30 2014-03-11 Nippon Zoki Pharmaceutical Co 哌啶衍生物
WO2009142772A2 (en) 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
ES2561227T3 (es) * 2008-08-01 2016-02-25 Nippon Zoki Pharmaceutical Co., Ltd. Derivado de aminopropilideno
CN102471326B (zh) * 2009-07-28 2015-04-29 日本脏器制药株式会社 硫杂苯并薁丙酸衍生物的制备方法
EA038594B1 (ru) 2011-10-28 2021-09-21 Шайр Хьюман Дженетик Терапис, Инк. Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
US8778971B2 (en) 2012-10-23 2014-07-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in companion animals
US8557846B1 (en) 2012-10-23 2013-10-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in dogs
US20150272941A1 (en) 2012-10-30 2015-10-01 Bridge Pharma, Inc. Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US20140120121A1 (en) 2012-10-30 2014-05-01 Bridge Pharma, Inc. Medicinal treatment of atopic inflammatory diseases
US9439895B2 (en) 2013-08-06 2016-09-13 Bridge Pharma, Inc. Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients
US9138431B2 (en) 2013-08-06 2015-09-22 Bridge Pharma, Inc. Methods of treatment of histamine H-4 receptor-related pruritus
US9345697B2 (en) 2013-08-06 2016-05-24 Bridge Pharma, Inc. Methods of treatment of non-histaminic pruritus
EP3307270B1 (de) 2015-06-11 2018-10-17 Bridge Pharma, Inc. Behandlungsmethode von nicht-histamin-bedingten pruritus bei säugetieren
MX2018011699A (es) 2018-09-26 2019-07-24 Federico Amezcua Amezcua Composicion farmaceutica sinergica de un antagonista de los receptores de leucotrienos y un agonista inverso de la histamina h1.
US10959992B2 (en) 2019-02-22 2021-03-30 Bridge Pharma Inc. Methods of treatment of asthma and COPD

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297097A (de) * 1962-08-31
FR1437412A (fr) * 1963-12-19 1966-05-06 Sandoz Sa Nouveaux benzo-cyclohepta-thiophènes et leur préparation
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
GB1084448A (en) * 1963-12-20 1967-09-20 Sandoz Ltd Improvements in or relating to 4h-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one derivatives
CH537897A (de) * 1968-03-20 1973-06-15 Hoffmann La Roche Verfahren zur Herstellung von tricyclischen Verbindungen
US3574199A (en) * 1968-06-28 1971-04-06 Searle & Co 6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3709947A (en) * 1971-07-26 1973-01-09 Searle & Co 6-chloropropylidene-1,1a,6,10b-tetrahydrobenzo(a,e)cyclopropa(c)cycloheptenes

Also Published As

Publication number Publication date
NL7111808A (de) 1972-03-28
OA03692A (fr) 1971-12-24
LU62757A1 (de) 1971-10-13
US3682930A (en) 1972-08-08
LU63829A1 (de) 1972-06-27
FR2085695A1 (de) 1971-12-31
SE368954B (de) 1974-07-29
OA03786A (fr) 1971-12-24
SE378820B (de) 1975-09-15
GB1360219A (en) 1974-07-17
DE2111071A1 (de) 1971-09-23
AT319238B (de) 1974-12-10
US3853915A (en) 1974-12-10
FR2107917A1 (de) 1972-05-12
DE2111071B2 (de) 1978-11-09
BE771964A (fr) 1972-02-29
FR2107917B1 (de) 1975-04-18
DE2144490A1 (de) 1972-03-30
GB1355539A (en) 1974-06-05
NL7103174A (de) 1971-09-14
US3770728A (en) 1973-11-06
GB1355537A (en) 1974-06-05
NL167431C (nl) 1981-12-16
FR2085695B1 (de) 1974-11-15
NL171449C (nl) 1983-04-05
GB1355538A (en) 1974-06-05
BE764019A (fr) 1971-09-09
CA960673A (en) 1975-01-07
DE2111071C3 (de) 1979-07-12
CA947767A (en) 1974-05-21
CH531000A (de) 1972-11-30
US3749786A (en) 1973-07-31

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Legal Events

Date Code Title Description
ELA Expired due to lapse of time