BR112022010505A2 - Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar - Google Patents

Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar

Info

Publication number
BR112022010505A2
BR112022010505A2 BR112022010505A BR112022010505A BR112022010505A2 BR 112022010505 A2 BR112022010505 A2 BR 112022010505A2 BR 112022010505 A BR112022010505 A BR 112022010505A BR 112022010505 A BR112022010505 A BR 112022010505A BR 112022010505 A2 BR112022010505 A2 BR 112022010505A2
Authority
BR
Brazil
Prior art keywords
compounds
benzothya
bile acid
diseases
azepine compounds
Prior art date
Application number
BR112022010505A
Other languages
English (en)
Inventor
Gillberg Per-Göran
Starke Ingemar
S Kulkarni Santosh
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Priority claimed from PCT/EP2020/084567 external-priority patent/WO2021110883A1/en
Publication of BR112022010505A2 publication Critical patent/BR112022010505A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPOSTOS DE BENZOTIA(DI)AZEPINA E SEU USO COMO MODULADORES DO ÁCIDO BILIAR. A invenção se refere a derivados de 1,5-benzotiazepina e 1,2,5-benzotiadiazepina da fórmula (I). Estes compostos são moduladores do ácido biliar tendo transportador de ácido biliar dependente de sódio apical (ASBT) e/ou atividade inibidora do transporte de ácido biliar do fígado (LBAT). A invenção também se refere às composições farmacêuticas compreendendo estes compostos e ao uso destes compostos no tratamento de doenças cardiovasculares, metabolismo do ácido graxo e distúrbios de utilização de glicose, doenças gastrointestinais e doenças do fígado.
BR112022010505A 2019-12-04 2020-12-04 Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar BR112022010505A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911049982 2019-12-04
PCT/EP2020/084567 WO2021110883A1 (en) 2019-12-04 2020-12-04 Benzothia(di)azepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
BR112022010505A2 true BR112022010505A2 (pt) 2022-09-06

Family

ID=76209525

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022010505A BR112022010505A2 (pt) 2019-12-04 2020-12-04 Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar

Country Status (17)

Country Link
US (3) US11180465B2 (pt)
EP (1) EP4069360B1 (pt)
JP (1) JP2023504645A (pt)
KR (1) KR20220109450A (pt)
CN (1) CN114761079B (pt)
AU (1) AU2020397448A1 (pt)
BR (1) BR112022010505A2 (pt)
CA (1) CA3158195A1 (pt)
CO (1) CO2022007172A2 (pt)
CR (1) CR20220315A (pt)
DK (1) DK4069360T3 (pt)
ES (1) ES2973549T3 (pt)
FI (1) FI4069360T3 (pt)
IL (1) IL293379A (pt)
MX (1) MX2022006731A (pt)
PE (1) PE20230234A1 (pt)
PL (1) PL4069360T3 (pt)

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Publication number Priority date Publication date Assignee Title
SI3400944T1 (sl) 2010-11-08 2020-11-30 Albireo Ab IBAT inhibitorji za zdravljenje bolezni jeter
JP6751020B2 (ja) 2014-06-25 2020-09-02 Ｅａファーマ株式会社 固形製剤及びその着色防止又は着色低減方法
EP3802504B1 (en) 2018-06-05 2023-01-18 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
WO2019245449A1 (en) 2018-06-20 2019-12-26 Albireo Ab Pharmaceutical formulation of odevixibat
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
ES2973355T3 (es) * 2019-12-04 2024-06-19 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
FI4069360T3 (fi) 2019-12-04 2024-02-20 Albireo Ab Bentsotia(di)atsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina
ES2972045T3 (es) * 2019-12-04 2024-06-10 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
EP4069247A1 (en) 2019-12-04 2022-10-12 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
CA3186857A1 (en) 2020-08-03 2022-02-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
EP4255565A1 (en) 2020-12-04 2023-10-11 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
WO2023237728A1 (en) * 2022-06-09 2023-12-14 Albireo Ab Treating hepatitis
WO2024059163A1 (en) * 2022-09-14 2024-03-21 Mirum Pharmaceuticals, Inc. Maralixibat solid forms, intermediates and processes of making same

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