ATE548043T1 - Polymorphe von 3-o-(3',3'- dimethylsuccinyl)betulinsäure-di-n-methyl-d- glucamin - Google Patents

Polymorphe von 3-o-(3',3'- dimethylsuccinyl)betulinsäure-di-n-methyl-d- glucamin

Info

Publication number
ATE548043T1
ATE548043T1 AT06749874T AT06749874T ATE548043T1 AT E548043 T1 ATE548043 T1 AT E548043T1 AT 06749874 T AT06749874 T AT 06749874T AT 06749874 T AT06749874 T AT 06749874T AT E548043 T1 ATE548043 T1 AT E548043T1
Authority
AT
Austria
Prior art keywords
dimethylsuccinyl
methyl
betulinic acid
glucamine
polymorphs
Prior art date
Application number
AT06749874T
Other languages
English (en)
Inventor
Michael H O'neill
Gary G Sweetapple
Randall M Walker
Arndt Hausherr
Gunter Koch
David E Martin
Original Assignee
Myrexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myrexis Inc filed Critical Myrexis Inc
Application granted granted Critical
Publication of ATE548043T1 publication Critical patent/ATE548043T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06749874T 2005-04-12 2006-04-12 Polymorphe von 3-o-(3',3'- dimethylsuccinyl)betulinsäure-di-n-methyl-d- glucamin ATE548043T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67022705P 2005-04-12 2005-04-12
PCT/US2006/013640 WO2006110810A2 (en) 2005-04-12 2006-04-12 Polymorphs of 3-o-(3',3'-dimethylsuccinyl) betulinic acid di-n-methyl-d-glucamine

Publications (1)

Publication Number Publication Date
ATE548043T1 true ATE548043T1 (de) 2012-03-15

Family

ID=37087667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06749874T ATE548043T1 (de) 2005-04-12 2006-04-12 Polymorphe von 3-o-(3',3'- dimethylsuccinyl)betulinsäure-di-n-methyl-d- glucamin

Country Status (14)

Country Link
US (1) US7799768B2 (de)
EP (1) EP1868613B1 (de)
JP (1) JP2008535923A (de)
CN (1) CN101160132A (de)
AT (1) ATE548043T1 (de)
AU (1) AU2006235486A1 (de)
BR (1) BRPI0610668A2 (de)
CA (1) CA2604720A1 (de)
ES (1) ES2383534T3 (de)
IL (1) IL186058A0 (de)
MX (1) MX2007011981A (de)
NO (1) NO20075758L (de)
RU (1) RU2007141631A (de)
WO (1) WO2006110810A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200837074A (en) 2006-11-03 2008-09-16 Panacos Pharmaceuticals Inc Extended triterpene derivatives
WO2008091532A1 (en) * 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
US20080294107A1 (en) * 2007-05-22 2008-11-27 Convergent Medical Solutions, Inc. Multiple robotic injections of prenatal medications based on scanned image
US20080294115A1 (en) * 2007-05-22 2008-11-27 Chen Raymond H Microscopic Tumor Injection Treatment
US20080294106A1 (en) * 2007-05-22 2008-11-27 Convergent Medical Solutions, Inc. Multiple robotic injections of anesthesia based on scanned image
US20080294141A1 (en) * 2007-05-22 2008-11-27 Convergent Medical Solutions, Inc. Multiple robotic injections of immunosuppressive drugs based on scanned image
WO2009146240A1 (en) * 2008-05-27 2009-12-03 Convergent Medical Solutions, Inc. Multiple robotic injections based on scanned image

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
JPH01143832A (ja) 1987-12-01 1989-06-06 Toa Nenryo Kogyo Kk 制癌剤
ATE156019T1 (de) * 1991-10-16 1997-08-15 Schering Corp Lipophile zusammensetzungen von oligosaccharid- antibiotikasalzen
FR2683531B1 (fr) 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5643884A (en) 1993-08-09 1997-07-01 Glycomed Incorporated Lupane triterpenoid derivatives
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US5648888A (en) * 1995-12-27 1997-07-15 Hydro-Quebec Power distribution substation
US5776912A (en) * 1996-12-20 1998-07-07 Schering Corporation Lipophilic oligosaccharide antibiotic compositions
US6043245A (en) 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
US6670345B1 (en) * 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
ATE348839T1 (de) * 1998-03-02 2007-01-15 Univ North Carolina Acylierte betulin- und dihydrobetulinderivate, ihre herstellung und verwendung
US6043254A (en) * 1998-04-03 2000-03-28 Boehringer Ingelheim Pharma Kg Indolinones having kinase-inhibiting activity
AU4331700A (en) 1999-04-07 2000-10-23 Virginia Commonwealth University Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
RU2174982C2 (ru) 1999-11-05 2001-10-20 Институт органической химии Уфимского научного центра РАН 3,28-ди-о-никотинат бетулина, проявляющий гепатопротекторную и анти-вич активность
US7276510B2 (en) * 2000-05-08 2007-10-02 Janssen Pharmaceutica, Inc. HIV replication inhibitors
JP2004509972A (ja) 2000-09-29 2004-04-02 リージェンツ　オブ　ザ　ユニバーシティ　オブ　ミネソタ 酵母に対する殺真菌活性を有するトリテルペン
JP4179768B2 (ja) 2001-10-01 2008-11-12 ポーラ化成工業株式会社 トリテルペン誘導体及びそれを含有する化合物
AU2003278930A1 (en) * 2002-09-26 2004-04-19 Niigata University Of Pharmacy And Applied Science Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7365221B2 (en) * 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
CA2540160A1 (en) * 2003-09-26 2005-04-07 Panacos Pharmaceuticals, Inc. Novel triterpene derivatives, preparation thereof and use thereof
MXPA06010592A (es) * 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
AU2006333084A1 (en) * 2005-12-16 2007-07-12 Panacos Pharmaceuticals, Inc. Preparation of pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid
WO2008086652A1 (en) 2007-01-12 2008-07-24 Guoning Yao Electrothermal oil radiator

Also Published As

Publication number Publication date
MX2007011981A (es) 2007-12-05
JP2008535923A (ja) 2008-09-04
US7799768B2 (en) 2010-09-21
EP1868613A2 (de) 2007-12-26
EP1868613B1 (de) 2012-03-07
IL186058A0 (en) 2008-08-07
NO20075758L (no) 2008-01-10
BRPI0610668A2 (pt) 2010-07-13
WO2006110810A2 (en) 2006-10-19
US20060252704A1 (en) 2006-11-09
WO2006110810A3 (en) 2007-03-29
CN101160132A (zh) 2008-04-09
RU2007141631A (ru) 2009-05-20
AU2006235486A1 (en) 2006-10-19
CA2604720A1 (en) 2006-10-19
ES2383534T3 (es) 2012-06-22
EP1868613A4 (de) 2008-04-30

Similar Documents

Publication Publication Date Title
EA200870019A1 (ru) Лактамовые соединения и способы их применения
EA200870216A1 (ru) Амидо соединения и их применение в качестве лекарственных средств
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
NO20064584L (no) Tetrahydropyridoindolderivater
BRPI0418251B8 (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo
TW200837074A (en) Extended triterpene derivatives
EA200701036A1 (ru) Лактамные соединения и их применение в качестве фармацевтических препаратов
EA200802203A1 (ru) Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов
CL2007000789A1 (es) Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer.
MX2009004475A (es) Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma.
EA200700118A1 (ru) Амидосоединения и их применение в качестве лекарственных средств
EA200602062A1 (ru) Амидосоединения и их применение в качестве фармацевтических средств
NO20064347L (no) Substituerte 1,2,3,4-tetrahydroisokinolinderivater
NO20082269L (no) Nye piperaziner som antimalariamidler
CY1108932T1 (el) Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
JP2009531457A5 (de)
EA201000436A1 (ru) Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью
BRPI0508854A (pt) sais farmacêuticos de ácido-3-o-(3',3'-dimetilsuccinil) betulìnico
ATE489371T1 (de) Benzamidglucokinaseaktivatoren
UY31305A1 (es) Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmacéuticas que las contienen.
NO20075758L (no) Polymorfer av 3-0-(3',3'-dimetylsuccinyl) betulin syre di-N-metyl-D-glukamin
SA522431498B1 (ar) مشتقات 3، 6-داي أمينو-بيريدازين-3-يل، تركيبات صيدلية تحتوي عليها واستخدامها في صورة عوامل مساعدة على تلاشي الخلايا
CY1109537T1 (el) Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης
CY1117174T1 (el) ΧΡΗΣΗ 24-norUDCA ΓΙΑ ΤΗΝ ΑΓΩΓΗ ΧΟΛΟΣΤΑΤΙΚΩΝ ΝΟΣΗΜΑΤΩΝ ΤΟΥ ΗΠΑΤΟΣ
CY1115961T1 (el) Ανυδρη μορφη κρυσταλλικης μηλεϊνικης ορβεπιταντης (orvepitant maleate)